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Gene Gene information from NCBI Gene database.
Entrez ID 339175
Gene name Methyltransferase 2A, tRNA N3-cytidine
Gene symbol METTL2A
Synonyms (NCBI Gene)
METTL2
Chromosome 17
Chromosome location 17q23.2
miRNA miRNA information provided by mirtarbase database.
424 Show/Hide all (424)
miRTarBase ID miRNA Experiments Reference
MIRT020020 hsa-miR-375 Microarray 20215506
MIRT049543 hsa-miR-92a-3p CLASH 23622248
MIRT043691 hsa-miR-342-3p CLASH 23622248
MIRT041654 hsa-miR-484 CLASH 23622248
MIRT039224 hsa-miR-454-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32427860
GO:0005737 Component Cytoplasm IDA 34268557
GO:0005737 Component Cytoplasm IEA
GO:0006399 Process TRNA metabolic process IMP 28655767
GO:0006400 Process TRNA modification IDA 34268557
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618902 25755 ENSG00000087995
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96IZ6
Protein name tRNA N(3)-cytidine methyltransferase METTL2A (EC 2.1.1.-) (Methyltransferase-like protein 2A)
Protein function S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13489 Methyltransf_23 139 → 344 Domain
Sequence
MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ
RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK
SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSA
TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL
CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ
LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQN
LVDRRLQVNRGKQLTM
YRVWIQCKYCKPLLSSTS
Sequence length 378
Interactions View interactions