MEGF6 (multiple EGF like domains 6)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 1953
• Gene name: Multiple EGF like domains 6
• Gene symbol: MEGF6
• Synonyms (NCBI Gene): EGFL3
• Chromosome: 1
• Chromosome location: 1p36.32

miRNA Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1142437	hsa-miR-1248	CLIP-seq
MIRT1142438	hsa-miR-1257	CLIP-seq
MIRT1142439	hsa-miR-1273f	CLIP-seq
MIRT1142440	hsa-miR-1292	CLIP-seq
MIRT1142441	hsa-miR-143	CLIP-seq
MIRT1142442	hsa-miR-146a	CLIP-seq
MIRT1142443	hsa-miR-146b-5p	CLIP-seq
MIRT1142444	hsa-miR-151-5p	CLIP-seq
MIRT1142445	hsa-miR-151b	CLIP-seq
MIRT1142446	hsa-miR-3134	CLIP-seq
MIRT1142447	hsa-miR-3157-5p	CLIP-seq
MIRT1142448	hsa-miR-3200-5p	CLIP-seq
MIRT1142449	hsa-miR-3614-3p	CLIP-seq
MIRT1142450	hsa-miR-3671	CLIP-seq
MIRT1142451	hsa-miR-3977	CLIP-seq
MIRT1142452	hsa-miR-4251	CLIP-seq
MIRT1142453	hsa-miR-4268	CLIP-seq
MIRT1142454	hsa-miR-4282	CLIP-seq
MIRT1142455	hsa-miR-4314	CLIP-seq
MIRT1142456	hsa-miR-4329	CLIP-seq
MIRT1142457	hsa-miR-4423-5p	CLIP-seq
MIRT1142458	hsa-miR-4434	CLIP-seq
MIRT1142459	hsa-miR-4448	CLIP-seq
MIRT1142460	hsa-miR-4450	CLIP-seq
MIRT1142461	hsa-miR-4471	CLIP-seq
MIRT1142462	hsa-miR-4495	CLIP-seq
MIRT1142463	hsa-miR-4516	CLIP-seq
MIRT1142464	hsa-miR-4646-5p	CLIP-seq
MIRT1142465	hsa-miR-4667-5p	CLIP-seq
MIRT1142466	hsa-miR-4700-5p	CLIP-seq
MIRT1142467	hsa-miR-4708-5p	CLIP-seq
MIRT1142468	hsa-miR-4760-5p	CLIP-seq
MIRT1142469	hsa-miR-4763-5p	CLIP-seq
MIRT1142470	hsa-miR-4764-5p	CLIP-seq
MIRT1142471	hsa-miR-4768-3p	CLIP-seq
MIRT1142472	hsa-miR-4770	CLIP-seq
MIRT1142473	hsa-miR-4778-3p	CLIP-seq
MIRT1142474	hsa-miR-589	CLIP-seq
MIRT1142475	hsa-miR-607	CLIP-seq
MIRT1142476	hsa-miR-637	CLIP-seq
MIRT1142477	hsa-miR-665	CLIP-seq
MIRT2040461	hsa-miR-128	CLIP-seq
MIRT2040462	hsa-miR-135a	CLIP-seq
MIRT2040463	hsa-miR-135b	CLIP-seq
MIRT2040464	hsa-miR-138	CLIP-seq
MIRT2040465	hsa-miR-146b-3p	CLIP-seq
MIRT2040466	hsa-miR-1976	CLIP-seq
MIRT2040467	hsa-miR-2052	CLIP-seq
MIRT2040468	hsa-miR-2116	CLIP-seq
MIRT2040469	hsa-miR-3654	CLIP-seq
MIRT2040470	hsa-miR-3663-5p	CLIP-seq
MIRT2040471	hsa-miR-370	CLIP-seq
MIRT2040472	hsa-miR-378	CLIP-seq
MIRT2040473	hsa-miR-378b	CLIP-seq
MIRT2040474	hsa-miR-378c	CLIP-seq
MIRT2040475	hsa-miR-378d	CLIP-seq
MIRT2040476	hsa-miR-378e	CLIP-seq
MIRT2040477	hsa-miR-378f	CLIP-seq
MIRT2040478	hsa-miR-378h	CLIP-seq
MIRT2040479	hsa-miR-378i	CLIP-seq
MIRT1142451	hsa-miR-3977	CLIP-seq
MIRT2040480	hsa-miR-422a	CLIP-seq
MIRT2040481	hsa-miR-4299	CLIP-seq
MIRT2040482	hsa-miR-4307	CLIP-seq
MIRT2040483	hsa-miR-4446-3p	CLIP-seq
MIRT2040484	hsa-miR-4492	CLIP-seq
MIRT2040485	hsa-miR-4498	CLIP-seq
MIRT2040486	hsa-miR-4527	CLIP-seq
MIRT2040487	hsa-miR-4677-5p	CLIP-seq
MIRT2040488	hsa-miR-4690-3p	CLIP-seq
MIRT2040489	hsa-miR-4721	CLIP-seq
MIRT2040490	hsa-miR-4728-5p	CLIP-seq
MIRT2040491	hsa-miR-4761-5p	CLIP-seq
MIRT2040492	hsa-miR-4802-3p	CLIP-seq
MIRT2040493	hsa-miR-617	CLIP-seq
MIRT2040494	hsa-miR-762	CLIP-seq
MIRT2040495	hsa-miR-765	CLIP-seq
MIRT2270246	hsa-miR-1228	CLIP-seq
MIRT2270247	hsa-miR-1238	CLIP-seq
MIRT2270248	hsa-miR-1247	CLIP-seq
MIRT2040461	hsa-miR-128	CLIP-seq
MIRT2270249	hsa-miR-1321	CLIP-seq
MIRT2270250	hsa-miR-1587	CLIP-seq
MIRT2270251	hsa-miR-1915	CLIP-seq
MIRT2040467	hsa-miR-2052	CLIP-seq
MIRT2270252	hsa-miR-298	CLIP-seq
MIRT2270253	hsa-miR-342-3p	CLIP-seq
MIRT2270254	hsa-miR-378g	CLIP-seq
MIRT2270255	hsa-miR-4253	CLIP-seq
MIRT2270256	hsa-miR-4264	CLIP-seq
MIRT2270257	hsa-miR-4270	CLIP-seq
MIRT2040482	hsa-miR-4307	CLIP-seq
MIRT1142455	hsa-miR-4314	CLIP-seq
MIRT2270258	hsa-miR-4441	CLIP-seq
MIRT2040484	hsa-miR-4492	CLIP-seq
MIRT2040485	hsa-miR-4498	CLIP-seq
MIRT2270259	hsa-miR-4651	CLIP-seq
MIRT2270260	hsa-miR-4656	CLIP-seq
MIRT2270261	hsa-miR-4672	CLIP-seq
MIRT2270262	hsa-miR-4675	CLIP-seq
MIRT2270263	hsa-miR-4691-5p	CLIP-seq
MIRT2270264	hsa-miR-4739	CLIP-seq
MIRT2270265	hsa-miR-4741	CLIP-seq
MIRT2270266	hsa-miR-4753-5p	CLIP-seq
MIRT2270267	hsa-miR-4756-5p	CLIP-seq
MIRT2270268	hsa-miR-608	CLIP-seq
MIRT2270269	hsa-miR-664	CLIP-seq
MIRT2040494	hsa-miR-762	CLIP-seq
MIRT2040495	hsa-miR-765	CLIP-seq
MIRT2390801	hsa-miR-3160-3p	CLIP-seq
MIRT2390802	hsa-miR-3713	CLIP-seq
MIRT2390803	hsa-miR-4487	CLIP-seq
MIRT2390804	hsa-miR-558	CLIP-seq
MIRT2453966	hsa-miR-1184	CLIP-seq
MIRT2453967	hsa-miR-1539	CLIP-seq
MIRT2270251	hsa-miR-1915	CLIP-seq
MIRT2453968	hsa-miR-3130-3p	CLIP-seq
MIRT2270255	hsa-miR-4253	CLIP-seq
MIRT2040483	hsa-miR-4446-3p	CLIP-seq
MIRT2453969	hsa-miR-4685-5p	CLIP-seq
MIRT2453970	hsa-miR-4726-3p	CLIP-seq
MIRT1142469	hsa-miR-4763-5p	CLIP-seq
MIRT2453971	hsa-miR-550a	CLIP-seq
MIRT2453967	hsa-miR-1539	CLIP-seq
MIRT2453968	hsa-miR-3130-3p	CLIP-seq
MIRT1142469	hsa-miR-4763-5p	CLIP-seq
MIRT2453971	hsa-miR-550a	CLIP-seq
MIRT2453966	hsa-miR-1184	CLIP-seq
MIRT2569351	hsa-miR-134	CLIP-seq
MIRT2453967	hsa-miR-1539	CLIP-seq
MIRT2270251	hsa-miR-1915	CLIP-seq
MIRT2569352	hsa-miR-3118	CLIP-seq
MIRT2453968	hsa-miR-3130-3p	CLIP-seq
MIRT2569353	hsa-miR-3136-5p	CLIP-seq
MIRT2270255	hsa-miR-4253	CLIP-seq
MIRT2569354	hsa-miR-4318	CLIP-seq
MIRT2569355	hsa-miR-4330	CLIP-seq
MIRT2569356	hsa-miR-4427	CLIP-seq
MIRT2569357	hsa-miR-4439	CLIP-seq
MIRT2040483	hsa-miR-4446-3p	CLIP-seq
MIRT1142461	hsa-miR-4471	CLIP-seq
MIRT2569358	hsa-miR-4513	CLIP-seq
MIRT2453969	hsa-miR-4685-5p	CLIP-seq
MIRT2453970	hsa-miR-4726-3p	CLIP-seq
MIRT1142469	hsa-miR-4763-5p	CLIP-seq
MIRT2453971	hsa-miR-550a	CLIP-seq
MIRT2569351	hsa-miR-134	CLIP-seq
MIRT2453967	hsa-miR-1539	CLIP-seq
MIRT2569352	hsa-miR-3118	CLIP-seq
MIRT2453968	hsa-miR-3130-3p	CLIP-seq
MIRT2569353	hsa-miR-3136-5p	CLIP-seq
MIRT2569354	hsa-miR-4318	CLIP-seq
MIRT2569355	hsa-miR-4330	CLIP-seq
MIRT2569356	hsa-miR-4427	CLIP-seq
MIRT2569357	hsa-miR-4439	CLIP-seq
MIRT1142461	hsa-miR-4471	CLIP-seq
MIRT2569358	hsa-miR-4513	CLIP-seq
MIRT1142469	hsa-miR-4763-5p	CLIP-seq
MIRT2453971	hsa-miR-550a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21078624
GO:0005576	Component	Extracellular region	IEA

Other IDs

• MIM: 604266
• HGNC: 3232
• e!Ensembl: ENSG00000162591

Protein

• UniProt ID: O75095
• Protein name: Multiple epidermal growth factor-like domains protein 6 (Multiple EGF-like domains protein 6) (Epidermal growth factor-like protein 3) (EGF-like protein 3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00053	Laminin_EGF	568 → 613	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	1128 → 1174	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	1175 → 1221	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	873 → 919	Laminin EGF domain	Domain
  PF00053	Laminin_EGF	1344 → 1391	Laminin EGF domain	Domain
  PF07645	EGF_CA	285 → 324	Calcium-binding EGF domain	Domain
  PF12661	hEGF	1005 → 1024	Human growth factor-like EGF	Domain
  PF12661	hEGF	1091 → 1110	Human growth factor-like EGF	Domain
  PF12661	hEGF	527 → 546	Human growth factor-like EGF	Domain
  PF12661	hEGF	919 → 938	Human growth factor-like EGF	Domain
  PF12661	hEGF	1048 → 1067	Human growth factor-like EGF	Domain
  PF14670	FXa_inhibition	165 → 200		Domain
  PF14670	FXa_inhibition	416 → 451		Domain

• Sequence:

  MSFLEEARAAGRAVVLALVLLLLPAVPVGASVPPRPLLPLQPGMPHVCAEQELTLVGRRQ
  PCVQALSHTVPVWKAGCGWQAWCVGHERRTVYYMGYRQVYTTEARTVLRCCRGWMQQPDE
  EGCLSAECSASLCFHGGRCVPGSAQPCHCPPGFQGPRCQYDVDECRTHNGGCQHRCVNTP
  GSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGR
  HCVRRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAADGKACEDVDECAAGLAQCAHGC
  LNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHGCSHTSAGPLCTCPRG
  YELDTDQRTCIDVDDCADSPCCQQVCTNNPGGYECGCYAGYRLSADGCGCEDVDECASSR
  GGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLDGELPFVRPLPHIAVLQDE
  LPQLFQDDDVGADEEEAELRGEHTLTEKFVCLDDSFGHDCSLTCDDCRNGGTCLLGLDGC
  DCPEGWTGLICNETCPPDTFGKNCSFSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPK
  GYYGKHCRKKCNCANRGRCHRLYGACLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPH
  TQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGECGKRCPA
  GFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWGL
  GCQEICPACQHAARCDPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRCSCANDGHCHP
  ATGHCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAGHGSCDAISGLCLCEAGYVGPRC
  EQQCPQGHFGPGCEQRCQCQHGAACDHVSGACTCPAGWRGTFCEHACPAGFFGLDCRSAC
  NCTAGAACDAVNGSCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHC
  APGWMGPSCLQACPAGLYGDNCRHSCLCQNGGTCDPVSGHCACPEGWAGLACEKECLPRD
  VRAGCRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQRCSCPPGAAC
  HHVTGACRCPPGFTGSGCEQACPPGSFGEDCAQMCQCPGENPACHPATGTCSCAAGYHGP
  SCQQRCPPGRYGPGCEQLCGCLNGGSCDAATGACRCPTGFLGTDCNLTCPQGRFGPNCTH
  VCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEHTCSCRNGGLCHASNGSC
  SCGLGWTGRHCELACPPGRYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPP
  GFHGAGCQGLCWCQHGAPCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGA
  PCDPVTGLCLCPPGRSGATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVDGYMG
  PTCREGGPLRLPENPSLAQGSAGTLPASSRPTSRSGGPARH

• Sequence length: 1541

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (13)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Uncertain significance; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLADDER EXSTROPHY	—	GWAS catalog	25763902	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	39753771	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	39753771	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	37069358	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC MASTOCYTOSIS	—	GWAS catalog	32752121	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bladder Exstrophy	Bladder Exstrophy	GWASCAT_DG	25763902		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29719292		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30670683		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for MEGF6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MEGF6.