MEG3 (maternally expressed 3)

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Gene Gene information from NCBI Gene database.
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Entrez ID 55384
Gene name Maternally expressed 3
Gene symbol MEG3
Synonyms (NCBI Gene)
FP504GTL2LINC00023NCRNA00023PRO0518PRO2160onco-lncRNA-83prebp1
Chromosome 14
Chromosome location 14q32.2
Summary This gene is a maternally expressed imprinted gene. Multiple alternatively spliced transcript variants have been transcribed from this gene and all of them are long non-coding RNAs (lncRNAs). This gene is expressed in many normal tissues, but its expressi
miRNA miRNA information provided by mirtarbase database.
18 Show/Hide all (18)
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miRTarBase ID miRNA Experiments Reference
MIRT731765 hsa-miR-181a-5p Luciferase reporter assayqRT-PCRWestern blot 26253106
MIRT731765 hsa-miR-181a-5p Luciferase reporter assayqRT-PCRWestern blot 26253106
MIRT731765 hsa-miR-181a-5p Luciferase reporter assayqRT-PCRWestern blot 26253106
MIRT731765 hsa-miR-181a-5p Luciferase reporter assayqRT-PCRWestern blot 26253106
MIRT731765 hsa-miR-181a-5p Luciferase reporter assayqRT-PCRWestern blot 26253106
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
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Transcription factor Regulation Reference
CTCF Unknown 16331412
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
5
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GO ID Ontology Definition Evidence Reference
GO:0006325 Process Chromatin organization IEA
GO:0016442 Component RISC complex IEA
GO:0030308 Process Negative regulation of cell growth IEA
GO:0035195 Process MiRNA-mediated post-transcriptional gene silencing IEA
GO:0141180 Function DsDNA-RNA triple helix-forming chromatin adaptor activity IDA 38456652
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
605636 14575 ENSG00000214548
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
MEG3-related disorder Uncertain significance; Likely benign; Benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (296)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
ACTH-Secreting Pituitary Adenoma Pituitary adenoma BEFREE 25126861
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of large intestine Colorectal Cancer BEFREE 30556866
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25992654, 27338053, 31211438
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 30867789
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 31392726
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Hepatocellular Carcinoma Liver carcinoma BEFREE 21625215, 26321746
★★★★★
★☆☆☆☆
Found in Text Mining only
AICARDI-GOUTIERES SYNDROME Aicardi Goutieres Syndrome BEFREE 29749532
★★★★★
★☆☆☆☆
Found in Text Mining only
Alveolar rhabdomyosarcoma Alveolar Rhabdomyosarcoma BEFREE 24173021
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 36895559 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 28814798
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for MEG3.

No additional diseases found yet through genes similar to MEG3.