MDM1 (Mdm1 nuclear protein)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 56890
• Gene name: Mdm1 nuclear protein
• Gene symbol: MDM1
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q15
• Summary: This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole

miRNA Show/Hide all (98)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029287	hsa-miR-26b-5p	Microarray	19088304
MIRT1138670	hsa-miR-1305	CLIP-seq
MIRT1138671	hsa-miR-3163	CLIP-seq
MIRT1138672	hsa-miR-3617	CLIP-seq
MIRT1138673	hsa-miR-421	CLIP-seq
MIRT1138674	hsa-miR-4282	CLIP-seq
MIRT1138675	hsa-miR-4668-3p	CLIP-seq
MIRT1138676	hsa-miR-4803	CLIP-seq
MIRT1138677	hsa-miR-513a-3p	CLIP-seq
MIRT1138678	hsa-miR-548c-3p	CLIP-seq
MIRT1138679	hsa-miR-641	CLIP-seq
MIRT1138680	hsa-miR-888	CLIP-seq
MIRT1138681	hsa-miR-142-5p	CLIP-seq
MIRT1138682	hsa-miR-3074-3p	CLIP-seq
MIRT1138683	hsa-miR-340	CLIP-seq
MIRT1138684	hsa-miR-4762-5p	CLIP-seq
MIRT1138685	hsa-miR-1197	CLIP-seq
MIRT1138686	hsa-miR-1265	CLIP-seq
MIRT1138687	hsa-miR-144	CLIP-seq
MIRT1138688	hsa-miR-2392	CLIP-seq
MIRT1138689	hsa-miR-3135	CLIP-seq
MIRT1138690	hsa-miR-369-3p	CLIP-seq
MIRT1138691	hsa-miR-374a	CLIP-seq
MIRT1138692	hsa-miR-374b	CLIP-seq
MIRT1138693	hsa-miR-4645-3p	CLIP-seq
MIRT1138694	hsa-miR-4766-3p	CLIP-seq
MIRT1138695	hsa-miR-548p	CLIP-seq
MIRT2039338	hsa-miR-545	CLIP-seq
MIRT2269423	hsa-miR-3074-5p	CLIP-seq
MIRT2465622	hsa-miR-4659a-3p	CLIP-seq
MIRT2465623	hsa-miR-4659b-3p	CLIP-seq
MIRT2465624	hsa-miR-515-5p	CLIP-seq
MIRT2465625	hsa-miR-548v	CLIP-seq
MIRT2465626	hsa-miR-942	CLIP-seq
MIRT2568596	hsa-miR-1207-3p	CLIP-seq
MIRT1138670	hsa-miR-1305	CLIP-seq
MIRT2568597	hsa-miR-138	CLIP-seq
MIRT2568598	hsa-miR-186	CLIP-seq
MIRT2568599	hsa-miR-3121-3p	CLIP-seq
MIRT2568600	hsa-miR-3149	CLIP-seq
MIRT2568601	hsa-miR-3185	CLIP-seq
MIRT2568602	hsa-miR-3192	CLIP-seq
MIRT2568603	hsa-miR-326	CLIP-seq
MIRT2568604	hsa-miR-330-5p	CLIP-seq
MIRT2568605	hsa-miR-3607-5p	CLIP-seq
MIRT2568606	hsa-miR-3611	CLIP-seq
MIRT2568607	hsa-miR-3613-3p	CLIP-seq
MIRT2568608	hsa-miR-3664-5p	CLIP-seq
MIRT2568609	hsa-miR-3941	CLIP-seq
MIRT2568610	hsa-miR-3973	CLIP-seq
MIRT2568611	hsa-miR-4291	CLIP-seq
MIRT2568612	hsa-miR-4314	CLIP-seq
MIRT2568613	hsa-miR-4495	CLIP-seq
MIRT2568614	hsa-miR-4646-5p	CLIP-seq
MIRT2568615	hsa-miR-466	CLIP-seq
MIRT2568616	hsa-miR-4666-5p	CLIP-seq
MIRT2568617	hsa-miR-4672	CLIP-seq
MIRT2568618	hsa-miR-4694-5p	CLIP-seq
MIRT2568619	hsa-miR-4714-5p	CLIP-seq
MIRT2568620	hsa-miR-4719	CLIP-seq
MIRT2568621	hsa-miR-4731-3p	CLIP-seq
MIRT2568622	hsa-miR-4801	CLIP-seq
MIRT1138677	hsa-miR-513a-3p	CLIP-seq
MIRT2568623	hsa-miR-520g	CLIP-seq
MIRT2568624	hsa-miR-520h	CLIP-seq
MIRT2039338	hsa-miR-545	CLIP-seq
MIRT2568625	hsa-miR-548k	CLIP-seq
MIRT2568626	hsa-miR-548n	CLIP-seq
MIRT2568627	hsa-miR-548t	CLIP-seq
MIRT2568628	hsa-miR-568	CLIP-seq
MIRT2568629	hsa-miR-576-3p	CLIP-seq
MIRT2568630	hsa-miR-607	CLIP-seq
MIRT1138680	hsa-miR-888	CLIP-seq
MIRT2568598	hsa-miR-186	CLIP-seq
MIRT2568599	hsa-miR-3121-3p	CLIP-seq
MIRT2568601	hsa-miR-3185	CLIP-seq
MIRT2568602	hsa-miR-3192	CLIP-seq
MIRT2568603	hsa-miR-326	CLIP-seq
MIRT2568604	hsa-miR-330-5p	CLIP-seq
MIRT2568605	hsa-miR-3607-5p	CLIP-seq
MIRT2568606	hsa-miR-3611	CLIP-seq
MIRT2568607	hsa-miR-3613-3p	CLIP-seq
MIRT2568608	hsa-miR-3664-5p	CLIP-seq
MIRT2568609	hsa-miR-3941	CLIP-seq
MIRT2568611	hsa-miR-4291	CLIP-seq
MIRT2568612	hsa-miR-4314	CLIP-seq
MIRT2568613	hsa-miR-4495	CLIP-seq
MIRT2568614	hsa-miR-4646-5p	CLIP-seq
MIRT2568615	hsa-miR-466	CLIP-seq
MIRT2568616	hsa-miR-4666-5p	CLIP-seq
MIRT2568617	hsa-miR-4672	CLIP-seq
MIRT2568619	hsa-miR-4714-5p	CLIP-seq
MIRT2568620	hsa-miR-4719	CLIP-seq
MIRT2568621	hsa-miR-4731-3p	CLIP-seq
MIRT2568622	hsa-miR-4801	CLIP-seq
MIRT2039338	hsa-miR-545	CLIP-seq
MIRT2568629	hsa-miR-576-3p	CLIP-seq
MIRT1138680	hsa-miR-888	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	26337392
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	26337392
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IDA	26337392
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0008017	Function	Microtubule binding	IMP	26337392
GO:0034451	Component	Centriolar satellite	IDA
GO:0046600	Process	Negative regulation of centriole replication	IEA
GO:0046600	Process	Negative regulation of centriole replication	IMP	26337392
GO:0060041	Process	Retina development in camera-type eye	IBA

Other IDs

• MIM: 613813
• HGNC: 29917
• e!Ensembl: ENSG00000111554

Protein

• UniProt ID: Q8TC05
• Protein name: Nuclear protein MDM1
• Protein function: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15501	MDM1	9 → 548	Nuclear protein MDM1	Family

• Sequence:

  MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPY
  HDPQISKSLEWNGAISESNVVASPEPEAPETPKSQEAEQKDVTQERVHSLEASRVPKRTR
  SHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGLDRLLRKKAGLTVV
  PSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPPFKGNSVIHETEYKRNFKG
  LSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLKLEAEMELKDLHQPKRKLTPWKHQR
  LGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPNQVKELREKAEFYRKRVQGTHFSRDHL
  NQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQ
  PQKNTTEKLGVSAPTIPVRRRLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFM
  GEQEKLDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAV
  LVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLRED
  SEDNIHKFAEATLPVSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNVGK
  ARMNNLQLPQHEAFNDEDEDRLSEISARSAASSLRAFQTLARAKKRKENFWGKT

• Sequence length: 714

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ATOPIC ECZEMA	—	GWAS catalog	34454985, 34594039, 40164604	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Age related macular degeneration	Age-related macular degeneration	BEFREE	18805803		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	32975231	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for MDM1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MDM1.