Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9665
Gene name	Meiosis regulator and mRNA stability factor 1
Gene symbol	MARF1
Synonyms (NCBI Gene)	KIAA0430LKAPLMKBPPP1R34
Chromosome	16
Chromosome location	16p13.11
Summary	This gene encodes a putative peroxisomal protein that appears to be conserved across Euteleostomi. In humans, it may be autoantigenic. [provided by RefSeq, Jul 2010]

miRTarBase ID	miRNA	Experiments	Reference
MIRT020922	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT020922	hsa-miR-155-5p	HITS-CLIP	22473208

19 Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0004540	Function	RNA nuclease activity	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IBA
GO:0005777	Component	Peroxisome	IDA	15932519
GO:0005777	Component	Peroxisome	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0006302	Process	Double-strand break repair	IEA
GO:0007143	Process	Female meiotic nuclear division	IEA
GO:0007143	Process	Female meiotic nuclear division	ISS
GO:0010468	Process	Regulation of gene expression	IEA
GO:0010468	Process	Regulation of gene expression	ISS
GO:0016020	Component	Membrane	HDA	19946888
GO:0030154	Process	Cell differentiation	IEA
GO:0048477	Process	Oogenesis	IEA
GO:0048477	Process	Oogenesis	ISS
GO:0051321	Process	Meiotic cell cycle	IEA
GO:1905762	Function	CCR4-NOT complex binding	IBA

MIM	HGNC	e!Ensembl
614593	29562	ENSG00000166783

Q9Y4F3

Protein name

Meiosis regulator and mRNA stability factor 1 (Limkain-b1) (Meiosis arrest female protein 1)

Protein function

Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent

PDB

2DGX , 2DIU , 6FDL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01936	NYN	352 → 493	NYN domain	Domain
PF11608	Limkain-b1	510 → 595	Limkain b1	Family
PF12872	OST-HTH	1485 → 1556	OST-HTH/LOTUS domain	Domain
PF12872	OST-HTH	1410 → 1482	OST-HTH/LOTUS domain	Domain
PF12872	OST-HTH	1099 → 1169	OST-HTH/LOTUS domain	Domain
PF12872	OST-HTH	1258 → 1329	OST-HTH/LOTUS domain	Domain
PF12872	OST-HTH	1334 → 1405	OST-HTH/LOTUS domain	Domain

Sequence

MMEGNGTENSCSRTRGWLQQDNDAKPWLWKFSNCFSRPEQTLPHSPQTKEYMENKKVAVE
LKDVPSPLHAGSKLFPAVPLPDIRSLQQPKIQLSSVPKVSCCAHCPNEPSTSPMRFGGGG
GGSGGTSSLIHPGALLDSQSTRTITCQVGSGFAFQSASSLQNASARNNLAGIASDFPSMC
LESNLSSCKHLPCCGKLHFQSCHGNVHKLHQFPSLQGCTSAGYFPCSDFTSGAPGHLEEH
ISQSELTPHLCTNSLHLNVVPPVCLKGSLYCEDCLNKPARNSIIDAAKVWPNIPPPNTQP
APLAVPLCNGCGTKGTGKETTLLLATSLGKAASKFGSPEVAVAGQVLENLPPIGVFWDIE
NCSVPSGRSATAVVQRIREKFFKGHREAEFICVCDISKENKEVIQELNNCQVTVAHINAT
AKNAADDKLRQSLRRFANTHTAPATVVLVSTDVNFALELSDLRHRHGFHIILVHKNQASE
ALLHHANELIRFEEFISDLPPRLPLKMPQCHTLLYVYNLPANKDGKSVSNRLRRLSDNCG
GKVLSITGCSAILRFINQDSAERAQKRMENEDVFGNRIIVSFTPKNRELCETKSSNAIAD
KVKSPKKLKNPKLCLIKDASEQSSSAKATPGKGSQANSGSATKNTNVKSLQELCRMESKT
GHRNSEHQQGHLRLVVPTHGNSSAAVSTPKNSGVAEPVYKTSQKKENLSARSVTSSPVEK
KDKEETVFQVSYPSAFSKLVASRQVSPLLASQSWSSRSMSPNLLNRASPLAFNIANSSSE
ADCPDPFANGADVQVSNIDYRLSRKELQQLLQEAFARHGKVKSVELSPHTDYQLKAVVQM
ENLQDAIGAVNSLHRYKIGSKKILVSLATGAASKSLSLLSAETMSVLQDAPACCLPLFKF
TDIYEKKFGHKLNVSDLYKLTDTVAIREQGNGRLVCLLPSSQARQSPLGSSQSHDGSSTN
CSPIIFEELEYHEPVCRQHCSNKDFSEHEFDPDSYKIPFVILSLKTFAPQVHSLLQTHEG
TVPLLSFPDCYIAEFGDLEVVQENQGGVPLEHFITCVPGVNIATAQNGIKVVKWIHNKPP
PPNTDPWLLRSKSPVGNPQLIQFSREVIDLLKSQPSCVIPISHFIPSYHHHFAKQCRVSD
YGYSKLIELLEAVPHVLQILGMGSKRLLTLTHRAQVKRFTQDLLKLLKSQASKQVIVREF
SQAYHWCFSKDWDVTEYGVCELIDIVSEIPDTTICLSQQDNEMVICIPKRERTQDEIERT
KQFSKDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLLELFEAIPDTLQVL
ECGEEKILTLTEVERFKALAAQFVKLLRSQKDNCLMMTDLLTEYAKTFGYTFRLQDYDVS
SISALTQKLCHVVKVADIESGRQIQLINRKSLRSLTAQLLVLLMSWEGTTHLSVEELKRH
YESTHNTPLNPCEYGFMTLTELLKSLPYLVEVFTNDKMEECVKLTSLYLFAKNVRSLLHT
YHYQQIFLHEFSMAYTKYVGETLQPKTYGHSSVEELLGAIPQVVWIKGHGHKRIVVLKND
MKSRLSSLSLSPANHENQPSEGERILEVPESHTASELKLGADGSGPSHTEQELLRLTDDS
PVDLLCAPVPSCLPSPQLRPDPVILQSADLIQFEERPQEPSEIMILNQEEKMEIPIPGKS
KTLTSDSSSSCISAAVPVPPCPSSETSESLLSKDPVESPAKKQPKNRVKLAANFSLAPIT
KL

Sequence length

1742

Interactions

View interactions

Related Genes Genes most often co-reported with MARF1 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for MARF1.

Diseases Linked via Similar Genes Diseases curated for genes most similar to MARF1 (see Related Genes above), that are NOT already directly curated for MARF1 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to MARF1.

MARF1 (meiosis regulator and mRNA stability factor 1)

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