MAPK8IP2 (mitogen-activated protein kinase 8 interacting protein 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23542
• Gene name: Mitogen-activated protein kinase 8 interacting protein 2
• Gene symbol: MAPK8IP2
• Synonyms (NCBI Gene): IB-2, IB2, JIP2, PRKM8IPL
• Chromosome: 22
• Chromosome location: 22q13.33
• Summary: This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [prov

miRNA Show/Hide all (189)

miRTarBase ID	miRNA	Experiments	Reference
MIRT038432	hsa-miR-296-3p	CLASH	23622248
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709272	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709272	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709272	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709272	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709272	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT709290	hsa-miR-4728-3p	HITS-CLIP	19536157
MIRT709289	hsa-miR-7162-3p	HITS-CLIP	19536157
MIRT709288	hsa-miR-655-5p	HITS-CLIP	19536157
MIRT709287	hsa-miR-377-5p	HITS-CLIP	19536157
MIRT709286	hsa-miR-6086	HITS-CLIP	19536157
MIRT709285	hsa-miR-3621	HITS-CLIP	19536157
MIRT709284	hsa-miR-4663	HITS-CLIP	19536157
MIRT709283	hsa-miR-7160-5p	HITS-CLIP	19536157
MIRT709282	hsa-miR-8077	HITS-CLIP	19536157
MIRT709281	hsa-miR-3180	HITS-CLIP	19536157
MIRT709280	hsa-miR-3180-3p	HITS-CLIP	19536157
MIRT709279	hsa-miR-3196	HITS-CLIP	19536157
MIRT709278	hsa-miR-6816-5p	HITS-CLIP	19536157
MIRT709277	hsa-miR-1237-5p	HITS-CLIP	19536157
MIRT709276	hsa-miR-4488	HITS-CLIP	19536157
MIRT709275	hsa-miR-4697-5p	HITS-CLIP	19536157
MIRT709274	hsa-miR-6846-5p	HITS-CLIP	19536157
MIRT709273	hsa-miR-6848-5p	HITS-CLIP	19536157
MIRT709272	hsa-miR-92a-2-5p	HITS-CLIP	19536157
MIRT709271	hsa-miR-4447	HITS-CLIP	19536157
MIRT709270	hsa-miR-4472	HITS-CLIP	19536157
MIRT755955	hsa-miR-665	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP), Immunohistochemistry (IHC), Flow cytometry, RNA pull down assay	38097567
MIRT1131151	hsa-miR-185	CLIP-seq
MIRT1131152	hsa-miR-204	CLIP-seq
MIRT1131153	hsa-miR-211	CLIP-seq
MIRT1131154	hsa-miR-3173-3p	CLIP-seq
MIRT1131155	hsa-miR-3202	CLIP-seq
MIRT1131156	hsa-miR-340	CLIP-seq
MIRT1131157	hsa-miR-3938	CLIP-seq
MIRT1131158	hsa-miR-4269	CLIP-seq
MIRT1131159	hsa-miR-4282	CLIP-seq
MIRT1131160	hsa-miR-4306	CLIP-seq
MIRT1131161	hsa-miR-4463	CLIP-seq
MIRT1131162	hsa-miR-4464	CLIP-seq
MIRT1131163	hsa-miR-4533	CLIP-seq
MIRT1131164	hsa-miR-4644	CLIP-seq
MIRT1131165	hsa-miR-4646-5p	CLIP-seq
MIRT1131166	hsa-miR-4747-5p	CLIP-seq
MIRT1131167	hsa-miR-4748	CLIP-seq
MIRT1131168	hsa-miR-4755-5p	CLIP-seq
MIRT1131169	hsa-miR-4768-3p	CLIP-seq
MIRT1131170	hsa-miR-623	CLIP-seq
MIRT755955	hsa-miR-665	CLIP-seq

Gene ontology (GO) Show/Hide all (42)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IDA	12244047
GO:0001540	Function	Amyloid-beta binding	NAS	12023290
GO:0001662	Process	Behavioral fear response	IEA
GO:0001662	Process	Behavioral fear response	ISS
GO:0005078	Function	MAP-kinase scaffold activity	IBA
GO:0005078	Function	MAP-kinase scaffold activity	IDA	10756100
GO:0005078	Function	MAP-kinase scaffold activity	IEA
GO:0005078	Function	MAP-kinase scaffold activity	NAS	10490659
GO:0005198	Function	Structural molecule activity	TAS	10490659
GO:0005515	Function	Protein binding	IPI	16273093, 20173330, 24658140, 25814554, 31980649, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	10490659
GO:0005737	Component	Cytoplasm	IEA
GO:0007172	Process	Signal complex assembly	TAS	10490659
GO:0007254	Process	JNK cascade	IBA
GO:0007254	Process	JNK cascade	IEA
GO:0007617	Process	Mating behavior	IEA
GO:0008432	Function	JUN kinase binding	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0019894	Function	Kinesin binding	IEA
GO:0019894	Function	Kinesin binding	ISS
GO:0019901	Function	Protein kinase binding	IPI	10490659
GO:0030295	Function	Protein kinase activator activity	IDA	12244047
GO:0030295	Function	Protein kinase activator activity	IGI	12244047
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	IEA
GO:0032991	Component	Protein-containing complex	IEA
GO:0035176	Process	Social behavior	IEA
GO:0035176	Process	Social behavior	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0046328	Process	Regulation of JNK cascade	IDA	10490659
GO:0046328	Process	Regulation of JNK cascade	IEA
GO:0046958	Process	Nonassociative learning	IEA
GO:0046958	Process	Nonassociative learning	ISS
GO:0048813	Process	Dendrite morphogenesis	IEA
GO:0048813	Process	Dendrite morphogenesis	ISS
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	IEA
GO:0051966	Process	Regulation of synaptic transmission, glutamatergic	ISS
GO:0098815	Process	Modulation of excitatory postsynaptic potential	IEA
GO:0098815	Process	Modulation of excitatory postsynaptic potential	ISS
GO:2001234	Process	Negative regulation of apoptotic signaling pathway	IDA	10756100

Other IDs

• MIM: 607755
• HGNC: 6883
• e!Ensembl: ENSG00000008735

Protein

• UniProt ID: Q13387
• Protein name: C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
• Protein function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin
• PDB: 8RPP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00640	PID	683 → 814	Phosphotyrosine interaction domain (PTB/PID)	Domain
  PF14604	SH3_9	611 → 661	Variant SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very lo
• Sequence:

  MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSL
  SLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPA
  PGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALR
  ELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGR
  GGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEA
  SSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMIS
  EGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP
  APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEE
  DAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDS
  GGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLV
  NGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYA
  HAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLR
  PPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLS
  RFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE

• Sequence length: 824

Pathways

KEGG Pathway:

MAPK signaling pathway

Related Genes

No strongly related genes found yet for MAPK8IP2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MAPK8IP2.