MAPDA (N6-Methyl-AMP deaminase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 161823
• Gene name: N6-Methyl-AMP deaminase
• Gene symbol: MAPDA
• Synonyms (NCBI Gene): ADAL, HsMAPDA
• Chromosome: 15
• Chromosome location: 15q15.3

miRNA Show/Hide all (138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT765729	hsa-miR-1275	CLIP-seq
MIRT765730	hsa-miR-185	CLIP-seq
MIRT765731	hsa-miR-3175	CLIP-seq
MIRT765732	hsa-miR-4306	CLIP-seq
MIRT765733	hsa-miR-4450	CLIP-seq
MIRT765734	hsa-miR-4525	CLIP-seq
MIRT765735	hsa-miR-4644	CLIP-seq
MIRT765736	hsa-miR-4665-5p	CLIP-seq
MIRT765737	hsa-miR-4667-5p	CLIP-seq
MIRT765738	hsa-miR-4700-5p	CLIP-seq
MIRT765739	hsa-miR-4723-5p	CLIP-seq
MIRT765740	hsa-miR-625	CLIP-seq
MIRT765741	hsa-miR-1200	CLIP-seq
MIRT765742	hsa-miR-1224-3p	CLIP-seq
MIRT765743	hsa-miR-1260	CLIP-seq
MIRT765744	hsa-miR-1260b	CLIP-seq
MIRT765745	hsa-miR-1280	CLIP-seq
MIRT765746	hsa-miR-132	CLIP-seq
MIRT765747	hsa-miR-143	CLIP-seq
MIRT765748	hsa-miR-202	CLIP-seq
MIRT765749	hsa-miR-2110	CLIP-seq
MIRT765750	hsa-miR-212	CLIP-seq
MIRT765751	hsa-miR-2278	CLIP-seq
MIRT765752	hsa-miR-28-3p	CLIP-seq
MIRT765753	hsa-miR-299-3p	CLIP-seq
MIRT765754	hsa-miR-3064-3p	CLIP-seq
MIRT765755	hsa-miR-3074-5p	CLIP-seq
MIRT765756	hsa-miR-3130-5p	CLIP-seq
MIRT765757	hsa-miR-3179	CLIP-seq
MIRT765758	hsa-miR-3185	CLIP-seq
MIRT765759	hsa-miR-3202	CLIP-seq
MIRT765760	hsa-miR-337-3p	CLIP-seq
MIRT765761	hsa-miR-3622a-3p	CLIP-seq
MIRT765762	hsa-miR-3622b-3p	CLIP-seq
MIRT765763	hsa-miR-3910	CLIP-seq
MIRT765764	hsa-miR-3920	CLIP-seq
MIRT765765	hsa-miR-3942-3p	CLIP-seq
MIRT765766	hsa-miR-3976	CLIP-seq
MIRT765767	hsa-miR-4252	CLIP-seq
MIRT765768	hsa-miR-4270	CLIP-seq
MIRT765769	hsa-miR-4271	CLIP-seq
MIRT765770	hsa-miR-4294	CLIP-seq
MIRT765771	hsa-miR-4300	CLIP-seq
MIRT765772	hsa-miR-4324	CLIP-seq
MIRT765773	hsa-miR-4441	CLIP-seq
MIRT765733	hsa-miR-4450	CLIP-seq
MIRT765774	hsa-miR-4475	CLIP-seq
MIRT765775	hsa-miR-4482	CLIP-seq
MIRT765776	hsa-miR-4502	CLIP-seq
MIRT765777	hsa-miR-4648	CLIP-seq
MIRT765778	hsa-miR-4654	CLIP-seq
MIRT765737	hsa-miR-4667-5p	CLIP-seq
MIRT765779	hsa-miR-4694-3p	CLIP-seq
MIRT765738	hsa-miR-4700-5p	CLIP-seq
MIRT765780	hsa-miR-4708-3p	CLIP-seq
MIRT765781	hsa-miR-4709-5p	CLIP-seq
MIRT765782	hsa-miR-4715-3p	CLIP-seq
MIRT765783	hsa-miR-4725-3p	CLIP-seq
MIRT765784	hsa-miR-4747-5p	CLIP-seq
MIRT765785	hsa-miR-4766-3p	CLIP-seq
MIRT765786	hsa-miR-4769-5p	CLIP-seq
MIRT765787	hsa-miR-4770	CLIP-seq
MIRT765788	hsa-miR-4797-5p	CLIP-seq
MIRT765789	hsa-miR-508-5p	CLIP-seq
MIRT765790	hsa-miR-539	CLIP-seq
MIRT765791	hsa-miR-548a-5p	CLIP-seq
MIRT765792	hsa-miR-548ab	CLIP-seq
MIRT765793	hsa-miR-548ak	CLIP-seq
MIRT765794	hsa-miR-548b-5p	CLIP-seq
MIRT765795	hsa-miR-548c-5p	CLIP-seq
MIRT765796	hsa-miR-548d-5p	CLIP-seq
MIRT765797	hsa-miR-548h	CLIP-seq
MIRT765798	hsa-miR-548i	CLIP-seq
MIRT765799	hsa-miR-548j	CLIP-seq
MIRT765800	hsa-miR-548k	CLIP-seq
MIRT765801	hsa-miR-548l	CLIP-seq
MIRT765802	hsa-miR-548w	CLIP-seq
MIRT765803	hsa-miR-548y	CLIP-seq
MIRT765804	hsa-miR-559	CLIP-seq
MIRT765805	hsa-miR-661	CLIP-seq
MIRT765806	hsa-miR-759	CLIP-seq
MIRT765807	hsa-miR-766	CLIP-seq
MIRT765808	hsa-miR-920	CLIP-seq
MIRT1925648	hsa-miR-1269	CLIP-seq
MIRT1925649	hsa-miR-1269b	CLIP-seq
MIRT1925650	hsa-miR-1288	CLIP-seq
MIRT1925651	hsa-miR-3165	CLIP-seq
MIRT1925652	hsa-miR-3169	CLIP-seq
MIRT1925653	hsa-miR-34b	CLIP-seq
MIRT1925654	hsa-miR-4515	CLIP-seq
MIRT1925655	hsa-miR-452	CLIP-seq
MIRT1925656	hsa-miR-4663	CLIP-seq
MIRT1925657	hsa-miR-4676-3p	CLIP-seq
MIRT1925658	hsa-miR-4740-5p	CLIP-seq
MIRT765742	hsa-miR-1224-3p	CLIP-seq
MIRT765743	hsa-miR-1260	CLIP-seq
MIRT765744	hsa-miR-1260b	CLIP-seq
MIRT765745	hsa-miR-1280	CLIP-seq
MIRT2167024	hsa-miR-1911	CLIP-seq
MIRT2167025	hsa-miR-3199	CLIP-seq
MIRT2167026	hsa-miR-3652	CLIP-seq
MIRT2167027	hsa-miR-3927	CLIP-seq
MIRT2167028	hsa-miR-4279	CLIP-seq
MIRT2167029	hsa-miR-4292	CLIP-seq
MIRT2167030	hsa-miR-4308	CLIP-seq
MIRT2167031	hsa-miR-4423-5p	CLIP-seq
MIRT2167032	hsa-miR-4430	CLIP-seq
MIRT2167033	hsa-miR-4456	CLIP-seq
MIRT2167034	hsa-miR-4505	CLIP-seq
MIRT2167035	hsa-miR-450b-3p	CLIP-seq
MIRT2167036	hsa-miR-4713-3p	CLIP-seq
MIRT2167037	hsa-miR-4772-5p	CLIP-seq
MIRT2167038	hsa-miR-512-3p	CLIP-seq
MIRT2167039	hsa-miR-532-3p	CLIP-seq
MIRT2167040	hsa-miR-552	CLIP-seq
MIRT2167041	hsa-miR-638	CLIP-seq
MIRT2167042	hsa-miR-769-3p	CLIP-seq
MIRT2383876	hsa-miR-3124-3p	CLIP-seq
MIRT2443116	hsa-miR-1267	CLIP-seq
MIRT2167026	hsa-miR-3652	CLIP-seq
MIRT2443117	hsa-miR-3664-5p	CLIP-seq
MIRT2167031	hsa-miR-4423-5p	CLIP-seq
MIRT2167032	hsa-miR-4430	CLIP-seq
MIRT2443118	hsa-miR-4639-3p	CLIP-seq
MIRT2443119	hsa-miR-494	CLIP-seq
MIRT2674368	hsa-miR-122	CLIP-seq
MIRT2674369	hsa-miR-1244	CLIP-seq
MIRT2443116	hsa-miR-1267	CLIP-seq
MIRT2674370	hsa-miR-3135b	CLIP-seq
MIRT2167026	hsa-miR-3652	CLIP-seq
MIRT2443117	hsa-miR-3664-5p	CLIP-seq
MIRT2167031	hsa-miR-4423-5p	CLIP-seq
MIRT2167032	hsa-miR-4430	CLIP-seq
MIRT2443118	hsa-miR-4639-3p	CLIP-seq
MIRT2674371	hsa-miR-4789-3p	CLIP-seq
MIRT2443119	hsa-miR-494	CLIP-seq
MIRT2674372	hsa-miR-510	CLIP-seq
MIRT2674373	hsa-miR-512-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004000	Function	Adenosine deaminase activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0006154	Process	Adenosine catabolic process	IBA
GO:0009117	Process	Nucleotide metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019239	Function	Deaminase activity	IEA
GO:0046103	Process	Inosine biosynthetic process	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0062154	Function	N6-methyl-AMP deaminase activity	IEA
GO:0097305	Process	Response to alcohol	IEA

Other IDs

• MIM: 619346
• HGNC: 31853
• e!Ensembl: ENSG00000168803

Protein

• UniProt ID: Q6DHV7
• Protein name: N6-Methyl-AMP deaminase (EC 3.5.4.-) (Adenosine deaminase-like protein) (N6-mAMP deaminase) (HsMAPDA) (N6-methyl-AMP aminohydrolase)
• Protein function: Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-m
• PDB: 8QCH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00962	A_deaminase	17 → 344	Adenosine/AMP deaminase	Domain

• Sequence:

  MIEAEEQQPCKTDFYSELPKVELHAHLNGSISSHTMKKLIAQKPDLKIHDQMTVIDKGKK
  RTLEECFQMFQTIHQLTSSPEDILMVTKDVIKEFADDGVKYLELRSTPRRENATGMTKKT
  YVESILEGIKQSKQENLDIDVRYLIAVDRRGGPLVAKETVKLAEEFFLSTEGTVLGLDLS
  GDPTVGQAKDFLEPLLEAKKAGLKLALHLSEIPNQKKETQILLDLLPDRIGHGTFLNSGE
  GGSLDLVDFVRQHRIPLELCLTSNVKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFAT
  HLSQEYQLAAETFNLTQSQVWDLSYESINYIFASDSTRSELRKKWNHLKPRVLHI

• Sequence length: 355

Pathways

Reactome Pathway

Abacavir metabolism

Purine salvage

Related Genes

No strongly related genes found yet for MAPDA.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MAPDA.