MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 8491
• Gene name: Mitogen-activated protein kinase kinase kinase kinase 3
• Gene symbol: MAP4K3
• Synonyms (NCBI Gene): GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1
• Chromosome: 2
• Chromosome location: 2p22.1
• Summary: This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observ

miRNA Show/Hide all (324)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029966	hsa-miR-26b-5p	Microarray	19088304
MIRT054069	hsa-let-7c-5p	H157	23981581
MIRT054069	hsa-let-7c-5p	H157	23981581
MIRT054069	hsa-let-7c-5p	Luciferase reporter assay, qRT-PCR, Western blot	28099144
MIRT054069	hsa-let-7c-5p	Luciferase reporter assay, qRT-PCR, Western blot	28099144
MIRT1129428	hsa-let-7a	CLIP-seq
MIRT1129429	hsa-let-7b	CLIP-seq
MIRT1129430	hsa-let-7c	CLIP-seq
MIRT1129431	hsa-let-7d	CLIP-seq
MIRT1129432	hsa-let-7e	CLIP-seq
MIRT1129433	hsa-let-7f	CLIP-seq
MIRT1129434	hsa-let-7g	CLIP-seq
MIRT1129435	hsa-let-7i	CLIP-seq
MIRT1129436	hsa-miR-1	CLIP-seq
MIRT1129437	hsa-miR-1184	CLIP-seq
MIRT1129438	hsa-miR-1202	CLIP-seq
MIRT1129439	hsa-miR-1301	CLIP-seq
MIRT1129440	hsa-miR-1323	CLIP-seq
MIRT1129441	hsa-miR-142-3p	CLIP-seq
MIRT1129442	hsa-miR-1914	CLIP-seq
MIRT1129443	hsa-miR-196a	CLIP-seq
MIRT1129444	hsa-miR-196b	CLIP-seq
MIRT1129445	hsa-miR-199b-5p	CLIP-seq
MIRT1129446	hsa-miR-19a	CLIP-seq
MIRT1129447	hsa-miR-19b	CLIP-seq
MIRT1129448	hsa-miR-200b	CLIP-seq
MIRT1129449	hsa-miR-200c	CLIP-seq
MIRT1129450	hsa-miR-202	CLIP-seq
MIRT1129451	hsa-miR-203	CLIP-seq
MIRT1129452	hsa-miR-206	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT1129454	hsa-miR-2116	CLIP-seq
MIRT1129455	hsa-miR-217	CLIP-seq
MIRT1129456	hsa-miR-27a	CLIP-seq
MIRT1129457	hsa-miR-27b	CLIP-seq
MIRT1129458	hsa-miR-297	CLIP-seq
MIRT1129459	hsa-miR-3129-3p	CLIP-seq
MIRT1129460	hsa-miR-3140-3p	CLIP-seq
MIRT1129461	hsa-miR-3149	CLIP-seq
MIRT1129462	hsa-miR-3174	CLIP-seq
MIRT1129463	hsa-miR-3187-3p	CLIP-seq
MIRT1129464	hsa-miR-3194-5p	CLIP-seq
MIRT1129465	hsa-miR-324-5p	CLIP-seq
MIRT1129466	hsa-miR-330-3p	CLIP-seq
MIRT1129467	hsa-miR-338-3p	CLIP-seq
MIRT1129468	hsa-miR-338-5p	CLIP-seq
MIRT1129469	hsa-miR-33a	CLIP-seq
MIRT1129470	hsa-miR-33b	CLIP-seq
MIRT1129471	hsa-miR-3591-3p	CLIP-seq
MIRT1129472	hsa-miR-3591-5p	CLIP-seq
MIRT1129473	hsa-miR-3606	CLIP-seq
MIRT1129474	hsa-miR-3617	CLIP-seq
MIRT1129475	hsa-miR-3673	CLIP-seq
MIRT1129476	hsa-miR-3688-3p	CLIP-seq
MIRT1129477	hsa-miR-374c	CLIP-seq
MIRT1129478	hsa-miR-3972	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129481	hsa-miR-4276	CLIP-seq
MIRT1129482	hsa-miR-4277	CLIP-seq
MIRT1129483	hsa-miR-4282	CLIP-seq
MIRT1129484	hsa-miR-429	CLIP-seq
MIRT1129485	hsa-miR-4302	CLIP-seq
MIRT1129486	hsa-miR-4317	CLIP-seq
MIRT1129487	hsa-miR-4320	CLIP-seq
MIRT1129488	hsa-miR-4418	CLIP-seq
MIRT1129489	hsa-miR-4424	CLIP-seq
MIRT1129490	hsa-miR-4435	CLIP-seq
MIRT1129491	hsa-miR-4458	CLIP-seq
MIRT1129492	hsa-miR-4500	CLIP-seq
MIRT1129493	hsa-miR-4528	CLIP-seq
MIRT1129494	hsa-miR-4529-5p	CLIP-seq
MIRT1129495	hsa-miR-4536	CLIP-seq
MIRT1129496	hsa-miR-4639-3p	CLIP-seq
MIRT1129497	hsa-miR-4660	CLIP-seq
MIRT1129498	hsa-miR-4677-5p	CLIP-seq
MIRT1129499	hsa-miR-4679	CLIP-seq
MIRT1129500	hsa-miR-4684-3p	CLIP-seq
MIRT1129501	hsa-miR-4700-3p	CLIP-seq
MIRT1129502	hsa-miR-4701-5p	CLIP-seq
MIRT1129503	hsa-miR-4777-5p	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129505	hsa-miR-499-3p	CLIP-seq
MIRT1129506	hsa-miR-499a-3p	CLIP-seq
MIRT1129507	hsa-miR-5047	CLIP-seq
MIRT1129508	hsa-miR-509-3-5p	CLIP-seq
MIRT1129509	hsa-miR-5095	CLIP-seq
MIRT1129510	hsa-miR-509-5p	CLIP-seq
MIRT1129511	hsa-miR-513a-5p	CLIP-seq
MIRT1129512	hsa-miR-518d-5p	CLIP-seq
MIRT1129513	hsa-miR-519b-5p	CLIP-seq
MIRT1129514	hsa-miR-519c-5p	CLIP-seq
MIRT1129515	hsa-miR-520c-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129518	hsa-miR-526a	CLIP-seq
MIRT1129519	hsa-miR-539	CLIP-seq
MIRT1129520	hsa-miR-548o	CLIP-seq
MIRT1129521	hsa-miR-548s	CLIP-seq
MIRT1129522	hsa-miR-582-5p	CLIP-seq
MIRT1129523	hsa-miR-588	CLIP-seq
MIRT1129524	hsa-miR-600	CLIP-seq
MIRT1129525	hsa-miR-613	CLIP-seq
MIRT1129526	hsa-miR-641	CLIP-seq
MIRT1129527	hsa-miR-655	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129529	hsa-miR-873	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT1129531	hsa-miR-921	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT1129533	hsa-miR-98	CLIP-seq
MIRT1129436	hsa-miR-1	CLIP-seq
MIRT1129438	hsa-miR-1202	CLIP-seq
MIRT2036913	hsa-miR-1273g	CLIP-seq
MIRT1129441	hsa-miR-142-3p	CLIP-seq
MIRT1129448	hsa-miR-200b	CLIP-seq
MIRT1129449	hsa-miR-200c	CLIP-seq
MIRT1129451	hsa-miR-203	CLIP-seq
MIRT1129452	hsa-miR-206	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT1129454	hsa-miR-2116	CLIP-seq
MIRT1129456	hsa-miR-27a	CLIP-seq
MIRT1129457	hsa-miR-27b	CLIP-seq
MIRT2036914	hsa-miR-3163	CLIP-seq
MIRT1129462	hsa-miR-3174	CLIP-seq
MIRT1129464	hsa-miR-3194-5p	CLIP-seq
MIRT1129465	hsa-miR-324-5p	CLIP-seq
MIRT1129467	hsa-miR-338-3p	CLIP-seq
MIRT1129469	hsa-miR-33a	CLIP-seq
MIRT1129470	hsa-miR-33b	CLIP-seq
MIRT1129472	hsa-miR-3591-5p	CLIP-seq
MIRT1129473	hsa-miR-3606	CLIP-seq
MIRT1129474	hsa-miR-3617	CLIP-seq
MIRT1129475	hsa-miR-3673	CLIP-seq
MIRT1129476	hsa-miR-3688-3p	CLIP-seq
MIRT1129478	hsa-miR-3972	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129481	hsa-miR-4276	CLIP-seq
MIRT1129482	hsa-miR-4277	CLIP-seq
MIRT1129484	hsa-miR-429	CLIP-seq
MIRT1129485	hsa-miR-4302	CLIP-seq
MIRT1129486	hsa-miR-4317	CLIP-seq
MIRT2036915	hsa-miR-4503	CLIP-seq
MIRT2036916	hsa-miR-4517	CLIP-seq
MIRT1129495	hsa-miR-4536	CLIP-seq
MIRT1129496	hsa-miR-4639-3p	CLIP-seq
MIRT2036917	hsa-miR-4670-3p	CLIP-seq
MIRT1129498	hsa-miR-4677-5p	CLIP-seq
MIRT1129500	hsa-miR-4684-3p	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129505	hsa-miR-499-3p	CLIP-seq
MIRT1129506	hsa-miR-499a-3p	CLIP-seq
MIRT1129511	hsa-miR-513a-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT2036918	hsa-miR-548n	CLIP-seq
MIRT2036919	hsa-miR-548t	CLIP-seq
MIRT1129522	hsa-miR-582-5p	CLIP-seq
MIRT1129525	hsa-miR-613	CLIP-seq
MIRT1129526	hsa-miR-641	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT1129531	hsa-miR-921	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT1129436	hsa-miR-1	CLIP-seq
MIRT1129437	hsa-miR-1184	CLIP-seq
MIRT1129438	hsa-miR-1202	CLIP-seq
MIRT2036913	hsa-miR-1273g	CLIP-seq
MIRT1129439	hsa-miR-1301	CLIP-seq
MIRT2266971	hsa-miR-134	CLIP-seq
MIRT1129441	hsa-miR-142-3p	CLIP-seq
MIRT1129445	hsa-miR-199b-5p	CLIP-seq
MIRT1129446	hsa-miR-19a	CLIP-seq
MIRT1129447	hsa-miR-19b	CLIP-seq
MIRT2266972	hsa-miR-2054	CLIP-seq
MIRT1129452	hsa-miR-206	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT1129455	hsa-miR-217	CLIP-seq
MIRT2266973	hsa-miR-23a	CLIP-seq
MIRT2266974	hsa-miR-23b	CLIP-seq
MIRT2266975	hsa-miR-23c	CLIP-seq
MIRT2266976	hsa-miR-3118	CLIP-seq
MIRT1129460	hsa-miR-3140-3p	CLIP-seq
MIRT2266977	hsa-miR-3164	CLIP-seq
MIRT1129464	hsa-miR-3194-5p	CLIP-seq
MIRT1129465	hsa-miR-324-5p	CLIP-seq
MIRT1129467	hsa-miR-338-3p	CLIP-seq
MIRT1129471	hsa-miR-3591-3p	CLIP-seq
MIRT1129474	hsa-miR-3617	CLIP-seq
MIRT2266978	hsa-miR-3651	CLIP-seq
MIRT2266979	hsa-miR-3662	CLIP-seq
MIRT1129475	hsa-miR-3673	CLIP-seq
MIRT1129476	hsa-miR-3688-3p	CLIP-seq
MIRT1129477	hsa-miR-374c	CLIP-seq
MIRT2266980	hsa-miR-376c	CLIP-seq
MIRT1129478	hsa-miR-3972	CLIP-seq
MIRT2266981	hsa-miR-3977	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129481	hsa-miR-4276	CLIP-seq
MIRT1129482	hsa-miR-4277	CLIP-seq
MIRT1129485	hsa-miR-4302	CLIP-seq
MIRT1129486	hsa-miR-4317	CLIP-seq
MIRT1129488	hsa-miR-4418	CLIP-seq
MIRT1129495	hsa-miR-4536	CLIP-seq
MIRT1129496	hsa-miR-4639-3p	CLIP-seq
MIRT1129497	hsa-miR-4660	CLIP-seq
MIRT1129500	hsa-miR-4684-3p	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129505	hsa-miR-499-3p	CLIP-seq
MIRT1129506	hsa-miR-499a-3p	CLIP-seq
MIRT1129507	hsa-miR-5047	CLIP-seq
MIRT1129508	hsa-miR-509-3-5p	CLIP-seq
MIRT1129510	hsa-miR-509-5p	CLIP-seq
MIRT1129522	hsa-miR-582-5p	CLIP-seq
MIRT1129525	hsa-miR-613	CLIP-seq
MIRT1129526	hsa-miR-641	CLIP-seq
MIRT1129527	hsa-miR-655	CLIP-seq
MIRT2266982	hsa-miR-758	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT2266983	hsa-miR-935	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT2266972	hsa-miR-2054	CLIP-seq
MIRT2266978	hsa-miR-3651	CLIP-seq
MIRT1129480	hsa-miR-4255	CLIP-seq
MIRT1129437	hsa-miR-1184	CLIP-seq
MIRT1129439	hsa-miR-1301	CLIP-seq
MIRT1129455	hsa-miR-217	CLIP-seq
MIRT1129460	hsa-miR-3140-3p	CLIP-seq
MIRT2430991	hsa-miR-3973	CLIP-seq
MIRT1129479	hsa-miR-409-3p	CLIP-seq
MIRT1129488	hsa-miR-4418	CLIP-seq
MIRT1129497	hsa-miR-4660	CLIP-seq
MIRT1129504	hsa-miR-498	CLIP-seq
MIRT1129507	hsa-miR-5047	CLIP-seq
MIRT1129508	hsa-miR-509-3-5p	CLIP-seq
MIRT1129510	hsa-miR-509-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT2430992	hsa-miR-548a-5p	CLIP-seq
MIRT2430993	hsa-miR-548ab	CLIP-seq
MIRT2430994	hsa-miR-548ak	CLIP-seq
MIRT2430995	hsa-miR-548b-5p	CLIP-seq
MIRT2430996	hsa-miR-548c-5p	CLIP-seq
MIRT2430997	hsa-miR-548d-5p	CLIP-seq
MIRT2430998	hsa-miR-548h	CLIP-seq
MIRT2430999	hsa-miR-548i	CLIP-seq
MIRT2431000	hsa-miR-548j	CLIP-seq
MIRT2431001	hsa-miR-548w	CLIP-seq
MIRT2431002	hsa-miR-548y	CLIP-seq
MIRT2431003	hsa-miR-559	CLIP-seq
MIRT1129530	hsa-miR-885-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129428	hsa-let-7a	CLIP-seq
MIRT1129429	hsa-let-7b	CLIP-seq
MIRT1129430	hsa-let-7c	CLIP-seq
MIRT1129431	hsa-let-7d	CLIP-seq
MIRT1129432	hsa-let-7e	CLIP-seq
MIRT1129433	hsa-let-7f	CLIP-seq
MIRT1129434	hsa-let-7g	CLIP-seq
MIRT1129435	hsa-let-7i	CLIP-seq
MIRT1129440	hsa-miR-1323	CLIP-seq
MIRT2266971	hsa-miR-134	CLIP-seq
MIRT1129442	hsa-miR-1914	CLIP-seq
MIRT1129443	hsa-miR-196a	CLIP-seq
MIRT1129444	hsa-miR-196b	CLIP-seq
MIRT1129448	hsa-miR-200b	CLIP-seq
MIRT1129449	hsa-miR-200c	CLIP-seq
MIRT1129450	hsa-miR-202	CLIP-seq
MIRT1129453	hsa-miR-2113	CLIP-seq
MIRT2566597	hsa-miR-224	CLIP-seq
MIRT1129458	hsa-miR-297	CLIP-seq
MIRT2266976	hsa-miR-3118	CLIP-seq
MIRT1129459	hsa-miR-3129-3p	CLIP-seq
MIRT1129461	hsa-miR-3149	CLIP-seq
MIRT2266977	hsa-miR-3164	CLIP-seq
MIRT1129463	hsa-miR-3187-3p	CLIP-seq
MIRT1129477	hsa-miR-374c	CLIP-seq
MIRT1129484	hsa-miR-429	CLIP-seq
MIRT1129490	hsa-miR-4435	CLIP-seq
MIRT1129491	hsa-miR-4458	CLIP-seq
MIRT1129492	hsa-miR-4500	CLIP-seq
MIRT2036916	hsa-miR-4517	CLIP-seq
MIRT1129493	hsa-miR-4528	CLIP-seq
MIRT1129494	hsa-miR-4529-5p	CLIP-seq
MIRT1129499	hsa-miR-4679	CLIP-seq
MIRT1129502	hsa-miR-4701-5p	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129520	hsa-miR-548o	CLIP-seq
MIRT1129521	hsa-miR-548s	CLIP-seq
MIRT1129523	hsa-miR-588	CLIP-seq
MIRT1129527	hsa-miR-655	CLIP-seq
MIRT2266982	hsa-miR-758	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129532	hsa-miR-944	CLIP-seq
MIRT1129533	hsa-miR-98	CLIP-seq
MIRT1129428	hsa-let-7a	CLIP-seq
MIRT1129429	hsa-let-7b	CLIP-seq
MIRT1129430	hsa-let-7c	CLIP-seq
MIRT1129431	hsa-let-7d	CLIP-seq
MIRT1129432	hsa-let-7e	CLIP-seq
MIRT1129433	hsa-let-7f	CLIP-seq
MIRT1129434	hsa-let-7g	CLIP-seq
MIRT1129435	hsa-let-7i	CLIP-seq
MIRT1129440	hsa-miR-1323	CLIP-seq
MIRT1129442	hsa-miR-1914	CLIP-seq
MIRT1129443	hsa-miR-196a	CLIP-seq
MIRT1129444	hsa-miR-196b	CLIP-seq
MIRT1129450	hsa-miR-202	CLIP-seq
MIRT1129458	hsa-miR-297	CLIP-seq
MIRT1129459	hsa-miR-3129-3p	CLIP-seq
MIRT1129461	hsa-miR-3149	CLIP-seq
MIRT1129491	hsa-miR-4458	CLIP-seq
MIRT1129492	hsa-miR-4500	CLIP-seq
MIRT1129493	hsa-miR-4528	CLIP-seq
MIRT1129499	hsa-miR-4679	CLIP-seq
MIRT1129516	hsa-miR-520d-5p	CLIP-seq
MIRT1129517	hsa-miR-524-5p	CLIP-seq
MIRT1129520	hsa-miR-548o	CLIP-seq
MIRT1129528	hsa-miR-802	CLIP-seq
MIRT1129533	hsa-miR-98	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004672	Function	Protein kinase activity	TAS	9275185
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9275185
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	17474147, 20936779, 21983831, 32707033, 33961781
GO:0005524	Function	ATP binding	IDA	9275185
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0006468	Process	Protein phosphorylation	IDA	9275185
GO:0007254	Process	JNK cascade	TAS	9275185
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IBA
GO:0008349	Function	MAP kinase kinase kinase kinase activity	IEA
GO:0009411	Process	Response to UV	IDA	9275185
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0034612	Process	Response to tumor necrosis factor	IDA	9275185
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IDA	9275185
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 604921
• HGNC: 6865
• e!Ensembl: ENSG00000011566

Protein

• UniProt ID: Q8IVH8
• Protein name: Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
• Protein function: Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control
• PDB: 5J5T
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00780	CNH	566 → 864	CNH domain	Family
  PF00069	Pkinase	16 → 273	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver. {ECO:0000269|PubMed:9275185}.
• Sequence:

  MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQ
  EIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRET
  LQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAP
  EVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKM
  KWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDF
  DDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLD
  SSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDD
  ESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPP
  PRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTP
  KVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLF
  PRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKF
  SVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPC
  PLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVT
  QLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQG
  RSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY

• Sequence length: 894

Pathways

KEGG Pathway:

MAPK signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ependymoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (26)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	23991104		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	23817999, 26791862, 30214937, 31640697		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	30221690		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26336805	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	27343552, 28099144, 31433582, 33204699	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31431460, 31640697		★☆☆☆☆ Found in Text Mining only
Congenital Hyperinsulinism	Hyperinsulinemic hypoglycemia	BEFREE	19146401		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	23817999		★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	34190178	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	33049985	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	31522654	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28099144, 31433582		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	22867055, 34610951	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	21983831, 22867055, 26791862, 31318609, 31766293		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31640697		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31431460, 31640697		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	26553456, 31640697		★☆☆☆☆ Found in Text Mining only
Multiple System Atrophy	Multiple system atrophy	Pubtator	27470294	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10804288, 19587239		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	23981581, 30221690, 31579095		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	19587239	Inhibit	★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	Pubtator	19587239	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	30904818		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	23817999		★☆☆☆☆ Found in Text Mining only
Sezary Syndrome	Sezary syndrome	Pubtator	28489605	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for MAP4K3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MAP4K3.