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Gene Gene information from NCBI Gene database.
Entrez ID 114569
Gene name Mal, T cell differentiation protein 2
Gene symbol MAL2
Synonyms (NCBI Gene)
-
Chromosome 8
Chromosome location 8q24.12
Summary This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for
miRNA miRNA information provided by mirtarbase database.
700 Show/Hide all (700)
miRTarBase ID miRNA Experiments Reference
MIRT018066 hsa-miR-335-5p Microarray 18185580
MIRT695789 hsa-miR-3156-5p HITS-CLIP 23313552
MIRT695788 hsa-miR-6715a-3p HITS-CLIP 23313552
MIRT695787 hsa-miR-4719 HITS-CLIP 23313552
MIRT695786 hsa-miR-6823-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12 Show/Hide all (12)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 12963375, 25416956, 26871637, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IEA
GO:0005886 Component Plasma membrane IEA
GO:0012505 Component Endomembrane system IEA
GO:0016020 Component Membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609684 13634 ENSG00000147676
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q969L2
Protein name Protein MAL2
Protein function Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01284 MARVEL 31 → 169 Membrane-associating domain Domain
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine. {ECO:0000269|PubMed:11549320, ECO:0000269|PubMed:14576188}.
Sequence
Sequence length 176
Interactions View interactions