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Gene Gene information from NCBI Gene database.
Entrez ID 7975
Gene name MAF bZIP transcription factor K
Gene symbol MAFK
Synonyms (NCBI Gene)
NFE2UP18
Chromosome 7
Chromosome location 7p22.3
Summary The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor
miRNA miRNA information provided by mirtarbase database.
565 Show/Hide all (565)
miRTarBase ID miRNA Experiments Reference
MIRT040737 hsa-miR-92b-3p CLASH 23622248
MIRT717982 hsa-miR-1224-3p HITS-CLIP 19536157
MIRT499521 hsa-miR-4258 HITS-CLIP 19536157
MIRT717981 hsa-miR-7108-3p HITS-CLIP 19536157
MIRT610969 hsa-miR-5193 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25 Show/Hide all (25)
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 9150357
GO:0000122 Process Negative regulation of transcription by RNA polymerase II NAS 27052415, 33897412
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription cis-regulatory region binding IEA
GO:0000976 Function Transcription cis-regulatory region binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600197 6782 ENSG00000198517
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O60675
Protein name Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit)
Protein function Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03131 bZIP_Maf 24 → 115 bZIP Maf transcription factor Coiled-coil
Sequence
MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLK
NRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQ
TFART
VARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS
Sequence length 156
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Factors involved in megakaryocyte development and platelet production