MAD2L1BP (MAD2L1 binding protein)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9587
• Gene name: MAD2L1 binding protein
• Gene symbol: MAD2L1BP
• Synonyms (NCBI Gene): CMT2, p31comet
• Chromosome: 6
• Chromosome location: 6p21.1
• Summary: The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to

miRNA Show/Hide all (112)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039833	hsa-miR-615-3p	CLASH	23622248
MIRT038190	hsa-miR-151a-5p	CLASH	23622248
MIRT1125078	hsa-miR-1197	CLIP-seq
MIRT1125079	hsa-miR-1276	CLIP-seq
MIRT1125080	hsa-miR-1343	CLIP-seq
MIRT1125081	hsa-miR-224	CLIP-seq
MIRT1125082	hsa-miR-2278	CLIP-seq
MIRT1125083	hsa-miR-3120-3p	CLIP-seq
MIRT1125084	hsa-miR-4326	CLIP-seq
MIRT1125085	hsa-miR-4468	CLIP-seq
MIRT1125086	hsa-miR-4475	CLIP-seq
MIRT1125087	hsa-miR-4490	CLIP-seq
MIRT1125088	hsa-miR-4766-5p	CLIP-seq
MIRT1125089	hsa-miR-488	CLIP-seq
MIRT1125090	hsa-miR-545	CLIP-seq
MIRT1125091	hsa-miR-548c-3p	CLIP-seq
MIRT1125078	hsa-miR-1197	CLIP-seq
MIRT1125079	hsa-miR-1276	CLIP-seq
MIRT1125080	hsa-miR-1343	CLIP-seq
MIRT1125081	hsa-miR-224	CLIP-seq
MIRT1125083	hsa-miR-3120-3p	CLIP-seq
MIRT1125084	hsa-miR-4326	CLIP-seq
MIRT1125087	hsa-miR-4490	CLIP-seq
MIRT1125088	hsa-miR-4766-5p	CLIP-seq
MIRT1125089	hsa-miR-488	CLIP-seq
MIRT1125090	hsa-miR-545	CLIP-seq
MIRT1125091	hsa-miR-548c-3p	CLIP-seq
MIRT2565094	hsa-miR-1226	CLIP-seq
MIRT2565095	hsa-miR-1229	CLIP-seq
MIRT2565096	hsa-miR-1251	CLIP-seq
MIRT2565097	hsa-miR-1262	CLIP-seq
MIRT2565098	hsa-miR-128	CLIP-seq
MIRT2565099	hsa-miR-1827	CLIP-seq
MIRT2565100	hsa-miR-2115	CLIP-seq
MIRT2565101	hsa-miR-27a	CLIP-seq
MIRT2565102	hsa-miR-27b	CLIP-seq
MIRT2565103	hsa-miR-3065-3p	CLIP-seq
MIRT2565104	hsa-miR-3153	CLIP-seq
MIRT2565105	hsa-miR-3166	CLIP-seq
MIRT2565106	hsa-miR-3183	CLIP-seq
MIRT2565107	hsa-miR-3184	CLIP-seq
MIRT2565108	hsa-miR-3192	CLIP-seq
MIRT2565109	hsa-miR-3200-5p	CLIP-seq
MIRT2565110	hsa-miR-326	CLIP-seq
MIRT2565111	hsa-miR-330-5p	CLIP-seq
MIRT2565112	hsa-miR-3612	CLIP-seq
MIRT2565113	hsa-miR-3908	CLIP-seq
MIRT2565114	hsa-miR-3977	CLIP-seq
MIRT2565115	hsa-miR-423-5p	CLIP-seq
MIRT2565116	hsa-miR-4291	CLIP-seq
MIRT2565117	hsa-miR-4311	CLIP-seq
MIRT2565118	hsa-miR-4314	CLIP-seq
MIRT2565119	hsa-miR-4428	CLIP-seq
MIRT2565120	hsa-miR-4434	CLIP-seq
MIRT2565121	hsa-miR-4516	CLIP-seq
MIRT2565122	hsa-miR-4531	CLIP-seq
MIRT2565123	hsa-miR-4646-5p	CLIP-seq
MIRT2565124	hsa-miR-4649-3p	CLIP-seq
MIRT2565125	hsa-miR-4668-5p	CLIP-seq
MIRT2565126	hsa-miR-4691-3p	CLIP-seq
MIRT2565127	hsa-miR-4701-3p	CLIP-seq
MIRT2565128	hsa-miR-4704-3p	CLIP-seq
MIRT2565129	hsa-miR-4714-3p	CLIP-seq
MIRT2565130	hsa-miR-4717-3p	CLIP-seq
MIRT2565131	hsa-miR-4723-3p	CLIP-seq
MIRT2565132	hsa-miR-4733-3p	CLIP-seq
MIRT2565133	hsa-miR-4802-3p	CLIP-seq
MIRT2565134	hsa-miR-516a-3p	CLIP-seq
MIRT1125090	hsa-miR-545	CLIP-seq
MIRT2565135	hsa-miR-582-5p	CLIP-seq
MIRT2565136	hsa-miR-618	CLIP-seq
MIRT2565137	hsa-miR-650	CLIP-seq
MIRT2565138	hsa-miR-873	CLIP-seq
MIRT2565094	hsa-miR-1226	CLIP-seq
MIRT2565095	hsa-miR-1229	CLIP-seq
MIRT2565096	hsa-miR-1251	CLIP-seq
MIRT2565098	hsa-miR-128	CLIP-seq
MIRT2565099	hsa-miR-1827	CLIP-seq
MIRT2565100	hsa-miR-2115	CLIP-seq
MIRT2565101	hsa-miR-27a	CLIP-seq
MIRT2565102	hsa-miR-27b	CLIP-seq
MIRT2565103	hsa-miR-3065-3p	CLIP-seq
MIRT2565104	hsa-miR-3153	CLIP-seq
MIRT2565105	hsa-miR-3166	CLIP-seq
MIRT2565106	hsa-miR-3183	CLIP-seq
MIRT2565107	hsa-miR-3184	CLIP-seq
MIRT2565108	hsa-miR-3192	CLIP-seq
MIRT2565109	hsa-miR-3200-5p	CLIP-seq
MIRT2565110	hsa-miR-326	CLIP-seq
MIRT2565111	hsa-miR-330-5p	CLIP-seq
MIRT2565112	hsa-miR-3612	CLIP-seq
MIRT2565113	hsa-miR-3908	CLIP-seq
MIRT2565114	hsa-miR-3977	CLIP-seq
MIRT2565115	hsa-miR-423-5p	CLIP-seq
MIRT2565116	hsa-miR-4291	CLIP-seq
MIRT2565117	hsa-miR-4311	CLIP-seq
MIRT2565118	hsa-miR-4314	CLIP-seq
MIRT2565119	hsa-miR-4428	CLIP-seq
MIRT2565123	hsa-miR-4646-5p	CLIP-seq
MIRT2565124	hsa-miR-4649-3p	CLIP-seq
MIRT2565125	hsa-miR-4668-5p	CLIP-seq
MIRT2565126	hsa-miR-4691-3p	CLIP-seq
MIRT2565128	hsa-miR-4704-3p	CLIP-seq
MIRT2565129	hsa-miR-4714-3p	CLIP-seq
MIRT2565131	hsa-miR-4723-3p	CLIP-seq
MIRT2565132	hsa-miR-4733-3p	CLIP-seq
MIRT2565134	hsa-miR-516a-3p	CLIP-seq
MIRT1125090	hsa-miR-545	CLIP-seq
MIRT2565135	hsa-miR-582-5p	CLIP-seq
MIRT2565136	hsa-miR-618	CLIP-seq
MIRT2565137	hsa-miR-650	CLIP-seq
MIRT2565138	hsa-miR-873	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16169070, 16189514, 18022368, 19060904, 21666598, 21772247, 25416956, 25502805, 26496610, 29892012, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	10942595
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	10942595
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0007096	Process	Regulation of exit from mitosis	IEA
GO:0007096	Process	Regulation of exit from mitosis	IMP	12456649
GO:0031965	Component	Nuclear membrane	IDA
GO:1902426	Process	Deactivation of mitotic spindle assembly checkpoint	IMP	18022368

Other IDs

• MIM: 618136
• HGNC: 21059
• e!Ensembl: ENSG00000124688

Protein

• UniProt ID: Q15013
• Protein name: MAD2L1-binding protein (Caught by MAD2 protein) (p31(comet))
• Protein function: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex.
• PDB: 2QYF , 6F0X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06581	p31comet	10 → 274	Mad1 and Cdc20-bound-Mad2 binding	Family

• Sequence:

  MAAPEAEVLSSAAVPDLEWYEKSEETHASQIELLETSSTQEPLNASEAFCPRDCMVPVVF
  PGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRKPSPQAEEMLKKKPRATTEVS
  SRKCQQALAELESVLSHLEDFFARTLVPRVLILLGGNALSPKEFYELDLSLLAPYSVDQS
  LSTAACLRRLFRAIFMADAFSELQAPPLMGTVVMAQGHRNCGEDWFRPKLNYRVPSRGHK
  LTVTLSCGRPSIRTTAWEDYIWFQAPVTFKGFRE

• Sequence length: 274

Pathways

KEGG Pathway:

Cell cycle

Related Genes

No strongly related genes found yet for MAD2L1BP.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to MAD2L1BP.