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Gene Gene information from NCBI Gene database.
Entrez ID 11313
Gene name Lysophospholipase 2
Gene symbol LYPLA2
Synonyms (NCBI Gene)
APT-2APT2DJ886K2.4
Chromosome 1
Chromosome location 1p36.11
Summary Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq
miRNA miRNA information provided by mirtarbase database.
392 Show/Hide all (392)
miRTarBase ID miRNA Experiments Reference
MIRT001444 hsa-miR-16-5p pSILAC 18668040
MIRT004990 hsa-miR-125b-5p Microarray 17891175
MIRT021526 hsa-miR-145-5p Reporter assay;Microarray 21351259
MIRT025639 hsa-miR-7-5p Microarray 19073608
MIRT001444 hsa-miR-16-5p Proteomics;Other 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26 Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IDA 25301951
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616143 6738 ENSG00000011009
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95372
Protein name Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22)
Protein function Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Me
PDB 5SYN , 6BJE
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02230 Abhydrolase_2 11 → 228 Phospholipase/Carboxylesterase Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in various breast cancer cell lines. {ECO:0000269|PubMed:25301951}.
Sequence
Sequence length 231
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Glycerophospholipid metabolism L1CAM interactions