LYPLA2 (lysophospholipase 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 11313 |
| Gene name | Lysophospholipase 2 |
| Gene symbol | LYPLA2 |
| Synonyms (NCBI Gene) |
APT-2APT2DJ886K2.4
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| Chromosome | 1 |
| Chromosome location | 1p36.11 |
| Summary | Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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O95372 | ||||||||||
| Protein name | Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II) (Palmitoyl-protein hydrolase) (EC 3.1.2.22) | ||||||||||
| Protein function | Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Me | ||||||||||
| PDB | 5SYN , 6BJE | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in various breast cancer cell lines. {ECO:0000269|PubMed:25301951}. | ||||||||||
| Sequence | |||||||||||
| Sequence length | 231 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Related Genes
Genes most often co-reported with LYPLA2 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to LYPLA2 (see Related Genes above), that are NOT already directly curated for LYPLA2 itself -- a lead worth checking, not a confirmed association.
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