LYNX1 (Ly6/neurotoxin 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 66004
• Gene name: Ly6/neurotoxin 1
• Gene symbol: LYNX1
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8q24.3
• Summary: This gene encodes a GPI-anchored, cell membrane bound member of the Ly6/uPAR (LU) superfamily of proteins containing the unique three-finger LU domain. This protein interacts with nicotinic acetylcholine receptors (nAChRs), and is thought to function as a

miRNA Show/Hide all (207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037680	hsa-miR-744-5p	CLASH	23622248
MIRT1123116	hsa-miR-1827	CLIP-seq
MIRT1123117	hsa-miR-193a-5p	CLIP-seq
MIRT1123118	hsa-miR-2116	CLIP-seq
MIRT1123119	hsa-miR-2861	CLIP-seq
MIRT1123120	hsa-miR-346	CLIP-seq
MIRT1123121	hsa-miR-370	CLIP-seq
MIRT1123122	hsa-miR-375	CLIP-seq
MIRT1123123	hsa-miR-4273	CLIP-seq
MIRT1123124	hsa-miR-4290	CLIP-seq
MIRT1123125	hsa-miR-4292	CLIP-seq
MIRT1123126	hsa-miR-4455	CLIP-seq
MIRT1123127	hsa-miR-4471	CLIP-seq
MIRT1123128	hsa-miR-4481	CLIP-seq
MIRT1123129	hsa-miR-4527	CLIP-seq
MIRT1123130	hsa-miR-4649-3p	CLIP-seq
MIRT1123131	hsa-miR-4658	CLIP-seq
MIRT1123132	hsa-miR-4663	CLIP-seq
MIRT1123133	hsa-miR-4677-5p	CLIP-seq
MIRT1123134	hsa-miR-4745-5p	CLIP-seq
MIRT1123135	hsa-miR-4758-5p	CLIP-seq
MIRT1123136	hsa-miR-526b	CLIP-seq
MIRT1123137	hsa-miR-609	CLIP-seq
MIRT1123138	hsa-miR-10a	CLIP-seq
MIRT1123139	hsa-miR-10b	CLIP-seq
MIRT1123140	hsa-miR-1253	CLIP-seq
MIRT1123141	hsa-miR-1289	CLIP-seq
MIRT1123116	hsa-miR-1827	CLIP-seq
MIRT1123142	hsa-miR-188-3p	CLIP-seq
MIRT1123143	hsa-miR-1913	CLIP-seq
MIRT1123144	hsa-miR-1914	CLIP-seq
MIRT1123119	hsa-miR-2861	CLIP-seq
MIRT1123145	hsa-miR-324-3p	CLIP-seq
MIRT1123146	hsa-miR-3612	CLIP-seq
MIRT1123147	hsa-miR-3620	CLIP-seq
MIRT1123148	hsa-miR-3665	CLIP-seq
MIRT1123121	hsa-miR-370	CLIP-seq
MIRT1123149	hsa-miR-3934	CLIP-seq
MIRT1123150	hsa-miR-3974	CLIP-seq
MIRT1123125	hsa-miR-4292	CLIP-seq
MIRT1123151	hsa-miR-4313	CLIP-seq
MIRT1123152	hsa-miR-4432	CLIP-seq
MIRT1123153	hsa-miR-4459	CLIP-seq
MIRT1123154	hsa-miR-451b	CLIP-seq
MIRT1123155	hsa-miR-4522	CLIP-seq
MIRT1123156	hsa-miR-4645-5p	CLIP-seq
MIRT1123130	hsa-miR-4649-3p	CLIP-seq
MIRT1123132	hsa-miR-4663	CLIP-seq
MIRT1123157	hsa-miR-4673	CLIP-seq
MIRT1123158	hsa-miR-4695-5p	CLIP-seq
MIRT1123159	hsa-miR-4696	CLIP-seq
MIRT1123160	hsa-miR-4713-3p	CLIP-seq
MIRT1123161	hsa-miR-4722-5p	CLIP-seq
MIRT1123162	hsa-miR-4736	CLIP-seq
MIRT1123163	hsa-miR-545	CLIP-seq
MIRT1123164	hsa-miR-650	CLIP-seq
MIRT1123165	hsa-miR-940	CLIP-seq
MIRT2034749	hsa-miR-140-3p	CLIP-seq
MIRT2034750	hsa-miR-190	CLIP-seq
MIRT2034751	hsa-miR-190b	CLIP-seq
MIRT2034752	hsa-miR-3201	CLIP-seq
MIRT2034753	hsa-miR-4717-3p	CLIP-seq
MIRT2034754	hsa-miR-4791	CLIP-seq
MIRT2034755	hsa-miR-4802-3p	CLIP-seq
MIRT2034756	hsa-miR-490-5p	CLIP-seq
MIRT2265261	hsa-miR-1470	CLIP-seq
MIRT2265262	hsa-miR-185	CLIP-seq
MIRT2265263	hsa-miR-1909	CLIP-seq
MIRT2265264	hsa-miR-3617	CLIP-seq
MIRT2265265	hsa-miR-4306	CLIP-seq
MIRT1123151	hsa-miR-4313	CLIP-seq
MIRT2265266	hsa-miR-4419a	CLIP-seq
MIRT1123153	hsa-miR-4459	CLIP-seq
MIRT2265267	hsa-miR-4510	CLIP-seq
MIRT2265268	hsa-miR-4644	CLIP-seq
MIRT2265269	hsa-miR-4667-3p	CLIP-seq
MIRT2265270	hsa-miR-4708-5p	CLIP-seq
MIRT2265271	hsa-miR-4779	CLIP-seq
MIRT2265272	hsa-miR-641	CLIP-seq
MIRT2390408	hsa-miR-1207-3p	CLIP-seq
MIRT2390409	hsa-miR-1224-3p	CLIP-seq
MIRT2390410	hsa-miR-3176	CLIP-seq
MIRT2390411	hsa-miR-3922-3p	CLIP-seq
MIRT2390412	hsa-miR-4286	CLIP-seq
MIRT2390413	hsa-miR-4660	CLIP-seq
MIRT2390414	hsa-miR-885-3p	CLIP-seq
MIRT1123117	hsa-miR-193a-5p	CLIP-seq
MIRT2390412	hsa-miR-4286	CLIP-seq
MIRT1123124	hsa-miR-4290	CLIP-seq
MIRT2453529	hsa-miR-4679	CLIP-seq
MIRT2453530	hsa-miR-4727-5p	CLIP-seq
MIRT2453531	hsa-miR-544	CLIP-seq
MIRT2564332	hsa-miR-1291	CLIP-seq
MIRT2564333	hsa-miR-1296	CLIP-seq
MIRT2564334	hsa-miR-139-3p	CLIP-seq
MIRT2564335	hsa-miR-15a	CLIP-seq
MIRT2564336	hsa-miR-15b	CLIP-seq
MIRT2564337	hsa-miR-16	CLIP-seq
MIRT2265263	hsa-miR-1909	CLIP-seq
MIRT2564338	hsa-miR-195	CLIP-seq
MIRT2564339	hsa-miR-214	CLIP-seq
MIRT2564340	hsa-miR-2909	CLIP-seq
MIRT2564341	hsa-miR-328	CLIP-seq
MIRT2564342	hsa-miR-3619-5p	CLIP-seq
MIRT2564343	hsa-miR-3622b-5p	CLIP-seq
MIRT2564344	hsa-miR-424	CLIP-seq
MIRT2564345	hsa-miR-4253	CLIP-seq
MIRT1123125	hsa-miR-4292	CLIP-seq
MIRT2564346	hsa-miR-4436b-3p	CLIP-seq
MIRT2564347	hsa-miR-4524	CLIP-seq
MIRT2564348	hsa-miR-4646-5p	CLIP-seq
MIRT2453529	hsa-miR-4679	CLIP-seq
MIRT2564349	hsa-miR-4688	CLIP-seq
MIRT2453530	hsa-miR-4727-5p	CLIP-seq
MIRT2564350	hsa-miR-4747-5p	CLIP-seq
MIRT2564351	hsa-miR-4761-3p	CLIP-seq
MIRT2564352	hsa-miR-497	CLIP-seq
MIRT2564353	hsa-miR-503	CLIP-seq
MIRT2453531	hsa-miR-544	CLIP-seq
MIRT2564354	hsa-miR-555	CLIP-seq
MIRT2564355	hsa-miR-646	CLIP-seq
MIRT2564356	hsa-miR-761	CLIP-seq
MIRT2684335	hsa-miR-1207-5p	CLIP-seq
MIRT2684336	hsa-miR-122	CLIP-seq
MIRT2684337	hsa-miR-1237	CLIP-seq
MIRT2684338	hsa-miR-1285	CLIP-seq
MIRT2564332	hsa-miR-1291	CLIP-seq
MIRT2564333	hsa-miR-1296	CLIP-seq
MIRT2564334	hsa-miR-139-3p	CLIP-seq
MIRT2564335	hsa-miR-15a	CLIP-seq
MIRT2564336	hsa-miR-15b	CLIP-seq
MIRT2564337	hsa-miR-16	CLIP-seq
MIRT1123116	hsa-miR-1827	CLIP-seq
MIRT2265262	hsa-miR-185	CLIP-seq
MIRT2265263	hsa-miR-1909	CLIP-seq
MIRT2564338	hsa-miR-195	CLIP-seq
MIRT2684339	hsa-miR-1972	CLIP-seq
MIRT2564339	hsa-miR-214	CLIP-seq
MIRT1123119	hsa-miR-2861	CLIP-seq
MIRT2564340	hsa-miR-2909	CLIP-seq
MIRT2684340	hsa-miR-3150b-3p	CLIP-seq
MIRT2684341	hsa-miR-3160-3p	CLIP-seq
MIRT2684342	hsa-miR-3182	CLIP-seq
MIRT2684343	hsa-miR-3187-5p	CLIP-seq
MIRT2684344	hsa-miR-3194-5p	CLIP-seq
MIRT2564341	hsa-miR-328	CLIP-seq
MIRT2684345	hsa-miR-338-3p	CLIP-seq
MIRT2265264	hsa-miR-3617	CLIP-seq
MIRT2564342	hsa-miR-3619-5p	CLIP-seq
MIRT2564343	hsa-miR-3622b-5p	CLIP-seq
MIRT2684346	hsa-miR-3690	CLIP-seq
MIRT2684347	hsa-miR-3911	CLIP-seq
MIRT2684348	hsa-miR-3945	CLIP-seq
MIRT2564344	hsa-miR-424	CLIP-seq
MIRT2564345	hsa-miR-4253	CLIP-seq
MIRT2684349	hsa-miR-4270	CLIP-seq
MIRT1123125	hsa-miR-4292	CLIP-seq
MIRT2684350	hsa-miR-4297	CLIP-seq
MIRT2265265	hsa-miR-4306	CLIP-seq
MIRT2684351	hsa-miR-4310	CLIP-seq
MIRT2684352	hsa-miR-4316	CLIP-seq
MIRT2265266	hsa-miR-4419a	CLIP-seq
MIRT2564346	hsa-miR-4436b-3p	CLIP-seq
MIRT2684353	hsa-miR-4441	CLIP-seq
MIRT1123153	hsa-miR-4459	CLIP-seq
MIRT1123128	hsa-miR-4481	CLIP-seq
MIRT2684354	hsa-miR-4487	CLIP-seq
MIRT2265267	hsa-miR-4510	CLIP-seq
MIRT2684355	hsa-miR-4514	CLIP-seq
MIRT2564347	hsa-miR-4524	CLIP-seq
MIRT2265268	hsa-miR-4644	CLIP-seq
MIRT1123156	hsa-miR-4645-5p	CLIP-seq
MIRT2564348	hsa-miR-4646-5p	CLIP-seq
MIRT1123157	hsa-miR-4673	CLIP-seq
MIRT2564349	hsa-miR-4688	CLIP-seq
MIRT2684356	hsa-miR-4689	CLIP-seq
MIRT2684357	hsa-miR-4692	CLIP-seq
MIRT2265270	hsa-miR-4708-5p	CLIP-seq
MIRT2684358	hsa-miR-4710	CLIP-seq
MIRT2684359	hsa-miR-4725-5p	CLIP-seq
MIRT1123134	hsa-miR-4745-5p	CLIP-seq
MIRT2564350	hsa-miR-4747-5p	CLIP-seq
MIRT2684360	hsa-miR-4755-3p	CLIP-seq
MIRT1123135	hsa-miR-4758-5p	CLIP-seq
MIRT2564351	hsa-miR-4761-3p	CLIP-seq
MIRT2684361	hsa-miR-4763-3p	CLIP-seq
MIRT2684362	hsa-miR-4763-5p	CLIP-seq
MIRT2265271	hsa-miR-4779	CLIP-seq
MIRT2684363	hsa-miR-4784	CLIP-seq
MIRT2684364	hsa-miR-4792	CLIP-seq
MIRT2684365	hsa-miR-4803	CLIP-seq
MIRT2564352	hsa-miR-497	CLIP-seq
MIRT2564353	hsa-miR-503	CLIP-seq
MIRT2684366	hsa-miR-504	CLIP-seq
MIRT2684367	hsa-miR-515-3p	CLIP-seq
MIRT2684368	hsa-miR-519e	CLIP-seq
MIRT2684369	hsa-miR-521	CLIP-seq
MIRT2564354	hsa-miR-555	CLIP-seq
MIRT2684370	hsa-miR-558	CLIP-seq
MIRT2684371	hsa-miR-574-5p	CLIP-seq
MIRT2684372	hsa-miR-612	CLIP-seq
MIRT2684373	hsa-miR-619	CLIP-seq
MIRT2265272	hsa-miR-641	CLIP-seq
MIRT2564355	hsa-miR-646	CLIP-seq
MIRT2684374	hsa-miR-711	CLIP-seq
MIRT2564356	hsa-miR-761	CLIP-seq
MIRT1123165	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007271	Process	Synaptic transmission, cholinergic	IEA
GO:0008200	Function	Ion channel inhibitor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030548	Function	Acetylcholine receptor regulator activity	IDA	21252236
GO:0030550	Function	Acetylcholine receptor inhibitor activity	IBA
GO:0030550	Function	Acetylcholine receptor inhibitor activity	IEA
GO:0033130	Function	Acetylcholine receptor binding	IBA
GO:0033130	Function	Acetylcholine receptor binding	IDA	21252236
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0095500	Process	Acetylcholine receptor signaling pathway	IBA
GO:0098552	Component	Side of membrane	IEA
GO:0099601	Process	Regulation of neurotransmitter receptor activity	IDA	21252236

Other IDs

• MIM: 606110
• HGNC: 29604
• e!Ensembl: ENSG00000180155

Protein

• UniProt ID: P0DP58
• Protein name: Ly-6/neurotoxin-like protein 1 (Endogenous prototoxin LYNX1) (Testicular tissue protein Li 112)
• Protein function: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:21252236). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effec
• PDB: 2L03
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00087	Toxin_TOLIP	21 → 92	Snake toxin and toxin-like protein	Domain

• Sequence:

  MTPLLTLILVVLMGLPLAQALDCHVCAYNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKV
  SKSCVPRCFETVYDGYSKHASTTSCCQYDLCNGTGLATPATLALAPILLATLWGLL

• Sequence length: 116

Pathways

KEGG Pathway:

Neuroactive ligand-receptor interaction

Related Genes

No strongly related genes found yet for LYNX1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LYNX1.