LTN1 (listerin E3 ubiquitin protein ligase 1)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26046
• Gene name: Listerin E3 ubiquitin protein ligase 1
• Gene symbol: LTN1
• Synonyms (NCBI Gene): C21orf10, C21orf98, RNF160, ZNF294
• Chromosome: 21
• Chromosome location: 21q21.3
• Summary: Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]

miRNA Show/Hide all (311)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005158	hsa-miR-30a-5p	pSILAC	18668040
MIRT018915	hsa-miR-335-5p	Microarray	18185580
MIRT021041	hsa-miR-155-5p	Proteomics	18668040
MIRT027323	hsa-miR-101-3p	Sequencing	20371350
MIRT005158	hsa-miR-30a-5p	Proteomics	18668040
MIRT031239	hsa-miR-19b-3p	Sequencing	20371350
MIRT039228	hsa-miR-454-3p	CLASH	23622248
MIRT036814	hsa-miR-877-3p	CLASH	23622248
MIRT439763	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT439763	ebv-miR-BART4-5p	HITS-CLIP	22473208
MIRT1122233	hsa-miR-1243	CLIP-seq
MIRT1122234	hsa-miR-1269	CLIP-seq
MIRT1122235	hsa-miR-1269b	CLIP-seq
MIRT1122236	hsa-miR-1279	CLIP-seq
MIRT1122237	hsa-miR-150	CLIP-seq
MIRT1122238	hsa-miR-188-3p	CLIP-seq
MIRT1122239	hsa-miR-191	CLIP-seq
MIRT1122240	hsa-miR-200b	CLIP-seq
MIRT1122241	hsa-miR-200c	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122243	hsa-miR-2909	CLIP-seq
MIRT1122244	hsa-miR-300	CLIP-seq
MIRT1122245	hsa-miR-3065-5p	CLIP-seq
MIRT1122246	hsa-miR-3122	CLIP-seq
MIRT1122247	hsa-miR-3123	CLIP-seq
MIRT1122248	hsa-miR-3154	CLIP-seq
MIRT1122249	hsa-miR-323b-3p	CLIP-seq
MIRT1122250	hsa-miR-3653	CLIP-seq
MIRT1122251	hsa-miR-3654	CLIP-seq
MIRT1122252	hsa-miR-3658	CLIP-seq
MIRT1122253	hsa-miR-376c	CLIP-seq
MIRT1122254	hsa-miR-381	CLIP-seq
MIRT1122255	hsa-miR-3913-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT1122257	hsa-miR-3925-5p	CLIP-seq
MIRT1122258	hsa-miR-3942-3p	CLIP-seq
MIRT1122259	hsa-miR-3974	CLIP-seq
MIRT1122260	hsa-miR-3976	CLIP-seq
MIRT1122261	hsa-miR-3978	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122263	hsa-miR-4278	CLIP-seq
MIRT1122264	hsa-miR-429	CLIP-seq
MIRT1122265	hsa-miR-4310	CLIP-seq
MIRT1122266	hsa-miR-4311	CLIP-seq
MIRT1122267	hsa-miR-433	CLIP-seq
MIRT1122268	hsa-miR-448	CLIP-seq
MIRT1122269	hsa-miR-4506	CLIP-seq
MIRT1122270	hsa-miR-450b-3p	CLIP-seq
MIRT1122271	hsa-miR-4529-3p	CLIP-seq
MIRT1122272	hsa-miR-4659a-3p	CLIP-seq
MIRT1122273	hsa-miR-4659b-3p	CLIP-seq
MIRT1122274	hsa-miR-4662a-3p	CLIP-seq
MIRT1122275	hsa-miR-4666-3p	CLIP-seq
MIRT1122276	hsa-miR-4713-5p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122278	hsa-miR-4729	CLIP-seq
MIRT1122279	hsa-miR-4786-3p	CLIP-seq
MIRT1122280	hsa-miR-4795-3p	CLIP-seq
MIRT1122281	hsa-miR-4799-5p	CLIP-seq
MIRT1122282	hsa-miR-495	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT1122284	hsa-miR-520d-5p	CLIP-seq
MIRT1122285	hsa-miR-524-5p	CLIP-seq
MIRT1122286	hsa-miR-532-3p	CLIP-seq
MIRT1122287	hsa-miR-544	CLIP-seq
MIRT1122288	hsa-miR-548p	CLIP-seq
MIRT1122289	hsa-miR-606	CLIP-seq
MIRT1122290	hsa-miR-629	CLIP-seq
MIRT1122291	hsa-miR-642a	CLIP-seq
MIRT1122292	hsa-miR-656	CLIP-seq
MIRT1122293	hsa-miR-769-3p	CLIP-seq
MIRT1122294	hsa-miR-875-3p	CLIP-seq
MIRT1122234	hsa-miR-1269	CLIP-seq
MIRT1122235	hsa-miR-1269b	CLIP-seq
MIRT1122239	hsa-miR-191	CLIP-seq
MIRT1122240	hsa-miR-200b	CLIP-seq
MIRT1122241	hsa-miR-200c	CLIP-seq
MIRT2034545	hsa-miR-2115	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122245	hsa-miR-3065-5p	CLIP-seq
MIRT2034546	hsa-miR-3607-5p	CLIP-seq
MIRT2034547	hsa-miR-3614-5p	CLIP-seq
MIRT2034548	hsa-miR-3620	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2034550	hsa-miR-3977	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122264	hsa-miR-429	CLIP-seq
MIRT2034551	hsa-miR-4328	CLIP-seq
MIRT1122269	hsa-miR-4506	CLIP-seq
MIRT1122271	hsa-miR-4529-3p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122280	hsa-miR-4795-3p	CLIP-seq
MIRT1122281	hsa-miR-4799-5p	CLIP-seq
MIRT2034552	hsa-miR-488	CLIP-seq
MIRT1122282	hsa-miR-495	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2034553	hsa-miR-516a-3p	CLIP-seq
MIRT1122287	hsa-miR-544	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT1122290	hsa-miR-629	CLIP-seq
MIRT2034555	hsa-miR-890	CLIP-seq
MIRT1122234	hsa-miR-1269	CLIP-seq
MIRT1122235	hsa-miR-1269b	CLIP-seq
MIRT2264993	hsa-miR-188-5p	CLIP-seq
MIRT2264994	hsa-miR-1912	CLIP-seq
MIRT2264995	hsa-miR-19a	CLIP-seq
MIRT2264996	hsa-miR-19b	CLIP-seq
MIRT1122240	hsa-miR-200b	CLIP-seq
MIRT1122241	hsa-miR-200c	CLIP-seq
MIRT2264997	hsa-miR-3121-5p	CLIP-seq
MIRT1122246	hsa-miR-3122	CLIP-seq
MIRT2264998	hsa-miR-3130-5p	CLIP-seq
MIRT2264999	hsa-miR-3157-3p	CLIP-seq
MIRT2265000	hsa-miR-361-3p	CLIP-seq
MIRT2034547	hsa-miR-3614-5p	CLIP-seq
MIRT2265001	hsa-miR-3688-3p	CLIP-seq
MIRT2265002	hsa-miR-3691-3p	CLIP-seq
MIRT1122255	hsa-miR-3913-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2034550	hsa-miR-3977	CLIP-seq
MIRT1122261	hsa-miR-3978	CLIP-seq
MIRT2265003	hsa-miR-4264	CLIP-seq
MIRT2265004	hsa-miR-4277	CLIP-seq
MIRT1122264	hsa-miR-429	CLIP-seq
MIRT2265005	hsa-miR-4482	CLIP-seq
MIRT2265006	hsa-miR-4502	CLIP-seq
MIRT2265007	hsa-miR-4503	CLIP-seq
MIRT1122270	hsa-miR-450b-3p	CLIP-seq
MIRT1122271	hsa-miR-4529-3p	CLIP-seq
MIRT2265008	hsa-miR-4775	CLIP-seq
MIRT2265009	hsa-miR-4797-3p	CLIP-seq
MIRT2265010	hsa-miR-500a	CLIP-seq
MIRT2265011	hsa-miR-501-5p	CLIP-seq
MIRT2265012	hsa-miR-576-3p	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT2265013	hsa-miR-622	CLIP-seq
MIRT1122293	hsa-miR-769-3p	CLIP-seq
MIRT2265014	hsa-miR-802	CLIP-seq
MIRT2034555	hsa-miR-890	CLIP-seq
MIRT2265015	hsa-miR-936	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT2390397	hsa-miR-3159	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122280	hsa-miR-4795-3p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2453503	hsa-miR-1197	CLIP-seq
MIRT2453504	hsa-miR-1285	CLIP-seq
MIRT2453505	hsa-miR-1286	CLIP-seq
MIRT2453506	hsa-miR-1323	CLIP-seq
MIRT2453507	hsa-miR-3187-5p	CLIP-seq
MIRT2453508	hsa-miR-4436a	CLIP-seq
MIRT2453509	hsa-miR-548a-3p	CLIP-seq
MIRT2453510	hsa-miR-548e	CLIP-seq
MIRT2453511	hsa-miR-548f	CLIP-seq
MIRT2453512	hsa-miR-548o	CLIP-seq
MIRT2453513	hsa-miR-612	CLIP-seq
MIRT2564073	hsa-miR-101	CLIP-seq
MIRT2453503	hsa-miR-1197	CLIP-seq
MIRT2564074	hsa-miR-1278	CLIP-seq
MIRT2453504	hsa-miR-1285	CLIP-seq
MIRT2453505	hsa-miR-1286	CLIP-seq
MIRT2453506	hsa-miR-1323	CLIP-seq
MIRT2564075	hsa-miR-144	CLIP-seq
MIRT2564076	hsa-miR-181a	CLIP-seq
MIRT2564077	hsa-miR-181b	CLIP-seq
MIRT2564078	hsa-miR-181c	CLIP-seq
MIRT2564079	hsa-miR-181d	CLIP-seq
MIRT2264994	hsa-miR-1912	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT2264998	hsa-miR-3130-5p	CLIP-seq
MIRT2564080	hsa-miR-3145-5p	CLIP-seq
MIRT2564081	hsa-miR-3157-5p	CLIP-seq
MIRT2564082	hsa-miR-3170	CLIP-seq
MIRT2453507	hsa-miR-3187-5p	CLIP-seq
MIRT2034546	hsa-miR-3607-5p	CLIP-seq
MIRT2564083	hsa-miR-3612	CLIP-seq
MIRT2564084	hsa-miR-3613-3p	CLIP-seq
MIRT2564085	hsa-miR-3662	CLIP-seq
MIRT2564086	hsa-miR-3671	CLIP-seq
MIRT2265001	hsa-miR-3688-3p	CLIP-seq
MIRT2564087	hsa-miR-3689a-5p	CLIP-seq
MIRT2564088	hsa-miR-3689b	CLIP-seq
MIRT2564089	hsa-miR-3689e	CLIP-seq
MIRT2564090	hsa-miR-3689f	CLIP-seq
MIRT2564091	hsa-miR-377	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2564092	hsa-miR-3929	CLIP-seq
MIRT1122261	hsa-miR-3978	CLIP-seq
MIRT2564093	hsa-miR-4256	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT2564094	hsa-miR-4260	CLIP-seq
MIRT2564095	hsa-miR-4262	CLIP-seq
MIRT2564096	hsa-miR-4266	CLIP-seq
MIRT2564097	hsa-miR-4282	CLIP-seq
MIRT2564098	hsa-miR-4419b	CLIP-seq
MIRT2453508	hsa-miR-4436a	CLIP-seq
MIRT2564099	hsa-miR-4436b-5p	CLIP-seq
MIRT2564100	hsa-miR-4470	CLIP-seq
MIRT2564101	hsa-miR-4473	CLIP-seq
MIRT2564102	hsa-miR-4478	CLIP-seq
MIRT2265005	hsa-miR-4482	CLIP-seq
MIRT2564103	hsa-miR-4493	CLIP-seq
MIRT2564104	hsa-miR-450b-5p	CLIP-seq
MIRT2564105	hsa-miR-4639-3p	CLIP-seq
MIRT2564106	hsa-miR-4668-3p	CLIP-seq
MIRT2564107	hsa-miR-4680-3p	CLIP-seq
MIRT2564108	hsa-miR-4695-5p	CLIP-seq
MIRT2564109	hsa-miR-4699-3p	CLIP-seq
MIRT2564110	hsa-miR-4724-5p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT2564111	hsa-miR-4762-3p	CLIP-seq
MIRT2564112	hsa-miR-4779	CLIP-seq
MIRT2564113	hsa-miR-4789-3p	CLIP-seq
MIRT2564114	hsa-miR-485-3p	CLIP-seq
MIRT2265010	hsa-miR-500a	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2564115	hsa-miR-508-5p	CLIP-seq
MIRT2564116	hsa-miR-512-3p	CLIP-seq
MIRT2564117	hsa-miR-513a-3p	CLIP-seq
MIRT2564118	hsa-miR-520f	CLIP-seq
MIRT2453509	hsa-miR-548a-3p	CLIP-seq
MIRT2453510	hsa-miR-548e	CLIP-seq
MIRT2453511	hsa-miR-548f	CLIP-seq
MIRT2453512	hsa-miR-548o	CLIP-seq
MIRT2564119	hsa-miR-579	CLIP-seq
MIRT2564120	hsa-miR-582-5p	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT2564121	hsa-miR-607	CLIP-seq
MIRT2453513	hsa-miR-612	CLIP-seq
MIRT2564122	hsa-miR-650	CLIP-seq
MIRT2265015	hsa-miR-936	CLIP-seq
MIRT2564073	hsa-miR-101	CLIP-seq
MIRT2564074	hsa-miR-1278	CLIP-seq
MIRT2453504	hsa-miR-1285	CLIP-seq
MIRT2453506	hsa-miR-1323	CLIP-seq
MIRT2564075	hsa-miR-144	CLIP-seq
MIRT1122242	hsa-miR-2467-5p	CLIP-seq
MIRT2264997	hsa-miR-3121-5p	CLIP-seq
MIRT1122246	hsa-miR-3122	CLIP-seq
MIRT2564080	hsa-miR-3145-5p	CLIP-seq
MIRT2564081	hsa-miR-3157-5p	CLIP-seq
MIRT2453507	hsa-miR-3187-5p	CLIP-seq
MIRT2034546	hsa-miR-3607-5p	CLIP-seq
MIRT2564083	hsa-miR-3612	CLIP-seq
MIRT2564084	hsa-miR-3613-3p	CLIP-seq
MIRT2265000	hsa-miR-361-3p	CLIP-seq
MIRT2564085	hsa-miR-3662	CLIP-seq
MIRT2564086	hsa-miR-3671	CLIP-seq
MIRT2564087	hsa-miR-3689a-5p	CLIP-seq
MIRT2564088	hsa-miR-3689b	CLIP-seq
MIRT2564089	hsa-miR-3689e	CLIP-seq
MIRT2564090	hsa-miR-3689f	CLIP-seq
MIRT2564091	hsa-miR-377	CLIP-seq
MIRT1122255	hsa-miR-3913-5p	CLIP-seq
MIRT1122256	hsa-miR-3922-5p	CLIP-seq
MIRT2034549	hsa-miR-3924	CLIP-seq
MIRT2564092	hsa-miR-3929	CLIP-seq
MIRT2564093	hsa-miR-4256	CLIP-seq
MIRT1122262	hsa-miR-4257	CLIP-seq
MIRT2564096	hsa-miR-4266	CLIP-seq
MIRT2564097	hsa-miR-4282	CLIP-seq
MIRT2564098	hsa-miR-4419b	CLIP-seq
MIRT2564099	hsa-miR-4436b-5p	CLIP-seq
MIRT2564100	hsa-miR-4470	CLIP-seq
MIRT2564101	hsa-miR-4473	CLIP-seq
MIRT2564102	hsa-miR-4478	CLIP-seq
MIRT2564103	hsa-miR-4493	CLIP-seq
MIRT1122270	hsa-miR-450b-3p	CLIP-seq
MIRT2564104	hsa-miR-450b-5p	CLIP-seq
MIRT2564105	hsa-miR-4639-3p	CLIP-seq
MIRT2564106	hsa-miR-4668-3p	CLIP-seq
MIRT2564107	hsa-miR-4680-3p	CLIP-seq
MIRT2564108	hsa-miR-4695-5p	CLIP-seq
MIRT2564110	hsa-miR-4724-5p	CLIP-seq
MIRT1122277	hsa-miR-4725-5p	CLIP-seq
MIRT2564111	hsa-miR-4762-3p	CLIP-seq
MIRT2564112	hsa-miR-4779	CLIP-seq
MIRT2564113	hsa-miR-4789-3p	CLIP-seq
MIRT2265010	hsa-miR-500a	CLIP-seq
MIRT2265011	hsa-miR-501-5p	CLIP-seq
MIRT1122283	hsa-miR-504	CLIP-seq
MIRT2564115	hsa-miR-508-5p	CLIP-seq
MIRT2564116	hsa-miR-512-3p	CLIP-seq
MIRT2564117	hsa-miR-513a-3p	CLIP-seq
MIRT2564118	hsa-miR-520f	CLIP-seq
MIRT2453509	hsa-miR-548a-3p	CLIP-seq
MIRT2453510	hsa-miR-548e	CLIP-seq
MIRT2453511	hsa-miR-548f	CLIP-seq
MIRT2453512	hsa-miR-548o	CLIP-seq
MIRT2564119	hsa-miR-579	CLIP-seq
MIRT2564120	hsa-miR-582-5p	CLIP-seq
MIRT2034554	hsa-miR-590-3p	CLIP-seq
MIRT2564121	hsa-miR-607	CLIP-seq
MIRT2453513	hsa-miR-612	CLIP-seq
MIRT2564122	hsa-miR-650	CLIP-seq
MIRT1122293	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0005515	Function	Protein binding	IPI	21903422
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	25578875, 28757607
GO:0005829	Component	Cytosol	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	25578875
GO:0043023	Function	Ribosomal large subunit binding	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051865	Process	Protein autoubiquitination	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	25578875
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0072344	Process	Rescue of stalled ribosome	IBA
GO:0072344	Process	Rescue of stalled ribosome	IDA	25578875
GO:1990112	Component	RQC complex	IBA
GO:1990112	Component	RQC complex	IDA	25578875
GO:1990112	Component	RQC complex	IEA
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IBA
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IDA	25578875
GO:1990116	Process	Ribosome-associated ubiquitin-dependent protein catabolic process	IEA

Other IDs

• MIM: 613083
• HGNC: 13082
• e!Ensembl: ENSG00000198862

Protein

• UniProt ID: O94822
• Protein name: E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294)
• Protein function: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:2368507
• PDB: 3J92
• Sequence:

  MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSL
  VDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRR
  VREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQP
  EAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLP
  DNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPS
  VLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIY
  PYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIM
  QQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTA
  HNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVR
  FADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADI
  SINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQ
  FLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIE
  KACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQ
  HVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLM
  PSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSA
  LWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQS
  LPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLEN
  NELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNR
  SREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKK
  EFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEH
  EDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSE
  NQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLL
  PILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQ
  TLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMS
  LLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYS
  MYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHI
  PHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQL
  FNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWM
  LQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKK
  FHSACLYKWFTSSNKSTCPLCRETFF

• Sequence length: 1766

Pathways

Reactome Pathway:

Antigen processing: Ubiquitination & Proteasome degradation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	39998322	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (6)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anodontia	Anodontia	Pubtator	19957108	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	29064472		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	33029194	Associate	★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	33049985	Associate	★☆☆☆☆ Found in Text Mining only
Schizoaffective Disorder	Schizoaffective Disorder	GWASCAT_DG	29064472		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	29064472		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for LTN1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LTN1.