LRWD1 (leucine rich repeats and WD repeat domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 222229
• Gene name: Leucine rich repeats and WD repeat domain containing 1
• Gene symbol: LRWD1
• Synonyms (NCBI Gene): CENP-33, ORCA
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: The protein encoded by this gene interacts with components of the origin recognition complex (ORC) and regulates the formation of the prereplicative complex. The encoded protein stabilizes the ORC and therefore aids in DNA replication. This protein is req

miRNA Show/Hide all (27)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023895	hsa-miR-1-3p	Proteomics	18668040
MIRT450335	hsa-miR-619-3p	PAR-CLIP	22100165
MIRT450334	hsa-miR-503-5p	PAR-CLIP	22100165
MIRT450333	hsa-miR-4491	PAR-CLIP	22100165
MIRT450332	hsa-miR-4657	PAR-CLIP	22100165
MIRT450331	hsa-miR-3661	PAR-CLIP	22100165
MIRT450330	hsa-miR-631	PAR-CLIP	22100165
MIRT450329	hsa-miR-769-5p	PAR-CLIP	22100165
MIRT450328	hsa-miR-4468	PAR-CLIP	22100165
MIRT450327	hsa-miR-4764-5p	PAR-CLIP	22100165
MIRT450326	hsa-miR-3138	PAR-CLIP	22100165
MIRT450325	hsa-miR-4800-5p	PAR-CLIP	22100165
MIRT450323	hsa-miR-5009-5p	PAR-CLIP	22100165
MIRT450324	hsa-miR-8058	PAR-CLIP	22100165
MIRT450335	hsa-miR-619-3p	PAR-CLIP	22100165
MIRT450334	hsa-miR-503-5p	PAR-CLIP	22100165
MIRT450333	hsa-miR-4491	PAR-CLIP	22100165
MIRT450332	hsa-miR-4657	PAR-CLIP	22100165
MIRT450331	hsa-miR-3661	PAR-CLIP	22100165
MIRT450330	hsa-miR-631	PAR-CLIP	22100165
MIRT450329	hsa-miR-769-5p	PAR-CLIP	22100165
MIRT450328	hsa-miR-4468	PAR-CLIP	22100165
MIRT450327	hsa-miR-4764-5p	PAR-CLIP	22100165
MIRT450326	hsa-miR-3138	PAR-CLIP	22100165
MIRT450325	hsa-miR-4800-5p	PAR-CLIP	22100165
MIRT450323	hsa-miR-5009-5p	PAR-CLIP	22100165
MIRT450324	hsa-miR-8058	PAR-CLIP	22100165

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000776	Component	Kinetochore	IDA	20813266
GO:0000776	Component	Kinetochore	IEA
GO:0000781	Component	Chromosome, telomeric region	IDA	20932478
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	20932478
GO:0005515	Function	Protein binding	IPI	20932478
GO:0005634	Component	Nucleus	IDA	18445686, 21029866
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005664	Component	Nuclear origin of replication recognition complex	IBA
GO:0005664	Component	Nuclear origin of replication recognition complex	IDA	20932478, 21029866
GO:0005694	Component	Chromosome	IEA
GO:0005721	Component	Pericentric heterochromatin	IDA	20932478
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006270	Process	DNA replication initiation	TAS	20932478
GO:0006325	Process	Chromatin organization	IBA
GO:0006325	Process	Chromatin organization	IEA
GO:0006325	Process	Chromatin organization	IMP	20932478
GO:0008327	Function	Methyl-CpG binding	IDA	21029866
GO:0061628	Function	Histone H3K27me3 reader activity	IDA	21029866
GO:0071169	Process	Establishment of protein localization to chromatin	IBA
GO:0071169	Process	Establishment of protein localization to chromatin	IDA	20932478

Other IDs

• MIM: 615167
• HGNC: 21769
• e!Ensembl: ENSG00000161036

Protein

• UniProt ID: Q9UFC0
• Protein name: Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)
• Protein function: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA an
• Tissue specificity: TISSUE SPECIFICITY: Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS). {ECO:0000269|PubMed:17074343}.
• Sequence:

  MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE
  TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR
  KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG
  PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPL
  SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF
  EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK
  RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW
  DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR
  RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA
  VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT
  QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM

• Sequence length: 647

Related Genes

No strongly related genes found yet for LRWD1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRWD1.