LRRTM2 (leucine rich repeat transmembrane neuronal 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 26045
• Gene name: Leucine rich repeat transmembrane neuronal 2
• Gene symbol: LRRTM2
• Synonyms (NCBI Gene): -
• Chromosome: 5
• Chromosome location: 5q31.2

miRNA Show/Hide all (223)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620930	hsa-miR-933	HITS-CLIP	23824327
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620930	hsa-miR-933	HITS-CLIP	23824327
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620927	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT620926	hsa-miR-8073	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620923	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT620922	hsa-miR-4284	HITS-CLIP	23824327
MIRT620921	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620917	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620916	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620912	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT620911	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT620927	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT620926	hsa-miR-8073	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620923	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT620922	hsa-miR-4284	HITS-CLIP	23824327
MIRT620921	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620917	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620916	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620912	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT620911	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT620930	hsa-miR-933	HITS-CLIP	23824327
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620927	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT620926	hsa-miR-8073	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620923	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT620922	hsa-miR-4284	HITS-CLIP	23824327
MIRT620921	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620917	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620916	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620912	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT620911	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620928	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620928	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620928	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT620930	hsa-miR-933	HITS-CLIP	27418678
MIRT620930	hsa-miR-933	HITS-CLIP	27418678
MIRT620930	hsa-miR-933	HITS-CLIP	27418678
MIRT620930	hsa-miR-933	HITS-CLIP	27418678
MIRT620930	hsa-miR-933	HITS-CLIP	23824327
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620930	hsa-miR-933	HITS-CLIP	23824327
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620927	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT620926	hsa-miR-8073	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620923	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT620922	hsa-miR-4284	HITS-CLIP	23824327
MIRT620921	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620917	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620916	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620912	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT620911	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT620927	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT620926	hsa-miR-8073	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620923	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT620922	hsa-miR-4284	HITS-CLIP	23824327
MIRT620921	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620917	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620916	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620912	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT620911	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT620930	hsa-miR-933	HITS-CLIP	23824327
MIRT620929	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT620928	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT620927	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT620926	hsa-miR-8073	HITS-CLIP	23824327
MIRT620925	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT620924	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT620923	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT620922	hsa-miR-4284	HITS-CLIP	23824327
MIRT620921	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT620920	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT620919	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT620918	hsa-miR-4693-5p	HITS-CLIP	23824327
MIRT620917	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT620916	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT620915	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT620914	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT620913	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT620912	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT620911	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT1121068	hsa-miR-1202	CLIP-seq
MIRT1121069	hsa-miR-1224-3p	CLIP-seq
MIRT740149	hsa-miR-1245	CLIP-seq
MIRT1121070	hsa-miR-1273g	CLIP-seq
MIRT1121071	hsa-miR-1289	CLIP-seq
MIRT1121072	hsa-miR-1290	CLIP-seq
MIRT1121073	hsa-miR-1913	CLIP-seq
MIRT1121074	hsa-miR-3129-3p	CLIP-seq
MIRT1121075	hsa-miR-3198	CLIP-seq
MIRT1121076	hsa-miR-3200-5p	CLIP-seq
MIRT1121077	hsa-miR-324-3p	CLIP-seq
MIRT1121078	hsa-miR-3682-3p	CLIP-seq
MIRT1121079	hsa-miR-3972	CLIP-seq
MIRT1121080	hsa-miR-3978	CLIP-seq
MIRT1121081	hsa-miR-4294	CLIP-seq
MIRT1121082	hsa-miR-4309	CLIP-seq
MIRT1121083	hsa-miR-4313	CLIP-seq
MIRT1121084	hsa-miR-4426	CLIP-seq
MIRT1121085	hsa-miR-4502	CLIP-seq
MIRT740150	hsa-miR-4519	CLIP-seq
MIRT1121086	hsa-miR-4521	CLIP-seq
MIRT1121087	hsa-miR-4534	CLIP-seq
MIRT1121088	hsa-miR-4647	CLIP-seq
MIRT1121089	hsa-miR-4662a-3p	CLIP-seq
MIRT1121090	hsa-miR-4662b	CLIP-seq
MIRT740148	hsa-miR-4678	CLIP-seq
MIRT1121091	hsa-miR-4693-3p	CLIP-seq
MIRT1121092	hsa-miR-4776-3p	CLIP-seq
MIRT1121093	hsa-miR-544	CLIP-seq
MIRT1121094	hsa-miR-548l	CLIP-seq
MIRT1121095	hsa-miR-548n	CLIP-seq
MIRT1121096	hsa-miR-584	CLIP-seq
MIRT1121070	hsa-miR-1273g	CLIP-seq
MIRT2034258	hsa-miR-203	CLIP-seq
MIRT2034259	hsa-miR-3134	CLIP-seq
MIRT2034260	hsa-miR-3148	CLIP-seq
MIRT2034261	hsa-miR-3653	CLIP-seq
MIRT2034262	hsa-miR-3658	CLIP-seq
MIRT2034263	hsa-miR-3688-3p	CLIP-seq
MIRT2034264	hsa-miR-3907	CLIP-seq
MIRT2034265	hsa-miR-412	CLIP-seq
MIRT2034266	hsa-miR-4476	CLIP-seq
MIRT1121087	hsa-miR-4534	CLIP-seq
MIRT2034267	hsa-miR-4659a-3p	CLIP-seq
MIRT2034268	hsa-miR-4659b-3p	CLIP-seq
MIRT1121091	hsa-miR-4693-3p	CLIP-seq
MIRT2034269	hsa-miR-550a	CLIP-seq
MIRT2034270	hsa-miR-595	CLIP-seq
MIRT2034271	hsa-miR-648	CLIP-seq
MIRT2264715	hsa-miR-151-3p	CLIP-seq
MIRT2264716	hsa-miR-183	CLIP-seq
MIRT2264717	hsa-miR-2053	CLIP-seq
MIRT2264718	hsa-miR-3117-5p	CLIP-seq
MIRT2264719	hsa-miR-3119	CLIP-seq
MIRT2264720	hsa-miR-3622b-5p	CLIP-seq
MIRT2264721	hsa-miR-3652	CLIP-seq
MIRT2264722	hsa-miR-3660	CLIP-seq
MIRT2264723	hsa-miR-4430	CLIP-seq
MIRT2264724	hsa-miR-4505	CLIP-seq
MIRT2264725	hsa-miR-4526	CLIP-seq
MIRT1121091	hsa-miR-4693-3p	CLIP-seq
MIRT2264726	hsa-miR-4694-3p	CLIP-seq
MIRT2264727	hsa-miR-522	CLIP-seq
MIRT2264728	hsa-miR-579	CLIP-seq
MIRT2264729	hsa-miR-892a	CLIP-seq
MIRT2390366	hsa-miR-4267	CLIP-seq
MIRT2390367	hsa-miR-4312	CLIP-seq
MIRT1121091	hsa-miR-4693-3p	CLIP-seq
MIRT2390368	hsa-miR-4764-3p	CLIP-seq
MIRT2390369	hsa-miR-490-3p	CLIP-seq
MIRT2390370	hsa-miR-508-5p	CLIP-seq
MIRT2390371	hsa-miR-649	CLIP-seq
MIRT2390372	hsa-miR-766	CLIP-seq
MIRT740149	hsa-miR-1245	CLIP-seq
MIRT740150	hsa-miR-4519	CLIP-seq
MIRT740148	hsa-miR-4678	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002091	Process	Negative regulation of receptor internalization	IEA
GO:0005515	Function	Protein binding	IPI	30262834, 32296183
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0042043	Function	Neurexin family protein binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050808	Process	Synapse organization	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0060076	Component	Excitatory synapse	IEA
GO:0060291	Process	Long-term synaptic potentiation	IEA
GO:0098685	Component	Schaffer collateral - CA1 synapse	IEA
GO:0098686	Component	Hippocampal mossy fiber to CA3 synapse	IEA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IDA	27565350
GO:0098982	Component	GABA-ergic synapse	IMP	27565350
GO:0099151	Process	Regulation of postsynaptic density assembly	IEA
GO:0099634	Component	Postsynaptic specialization membrane	IDA	27565350
GO:0099634	Component	Postsynaptic specialization membrane	IMP	27565350

Other IDs

• MIM: 610868
• HGNC: 19409
• e!Ensembl: ENSG00000146006

Protein

• UniProt ID: O43300
• Protein name: Leucine-rich repeat transmembrane neuronal protein 2 (Leucine-rich repeat neuronal 2 protein)
• Protein function: Involved in the development and maintenance of excitatory synapses in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the pre
• PDB: 5Z8X , 5Z8Y
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	133 → 193	Leucine rich repeat	Repeat
  PF13855	LRR_8	65 → 121	Leucine rich repeat	Repeat
  PF13855	LRR_8	253 → 312	Leucine rich repeat	Repeat
  PF13855	LRR_8	186 → 241	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in neuronal tissues. {ECO:0000269|PubMed:12676565}.
• Sequence:

  MGLHFKWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATD
  KGSLGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNK
  IFYLPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDC
  RSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNK
  ISNLTCGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSL
  RSLTTVGLSGNLWECSARICALASWLGSFQGRWEHSILCHSPDHTQGEDILDAVHGFQLC
  WNLSTTVTVMATTYRDPTTEYTKRISSSSYHVGDKEIPTTAGIAVTTEEHFPEPDNAIFT
  QRVITGTMALLFSFFFIIFIVFISRKCCPPTLRRIRQCSMVQNHRQLRSQTRLHMSNMSD
  QGPYNEYEPTHEGPFIIINGYGQCKCQQLPYKECEV

• Sequence length: 516

Pathways

Reactome Pathway:

Neurexins and neuroligins

Related Genes

No strongly related genes found yet for LRRTM2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRRTM2.