LRRC63 (leucine rich repeat containing 63)

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Gene Gene information from NCBI Gene database.
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Entrez ID 220416
Gene name Leucine rich repeat containing 63
Gene symbol LRRC63
Synonyms (NCBI Gene)
-
Chromosome 13
Chromosome location 13q14.13
miRNA miRNA information provided by mirtarbase database.
36 Show/Hide all (36)
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miRTarBase ID miRNA Experiments Reference
MIRT514214 hsa-miR-1277-5p HITS-CLIP 21572407
MIRT514208 hsa-miR-410-3p HITS-CLIP 21572407
MIRT514207 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT514204 hsa-miR-190a-3p HITS-CLIP 21572407
MIRT514216 hsa-miR-548at-5p PAR-CLIP 23446348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
1
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GO ID Ontology Definition Evidence Reference
GO:0035556 Process Intracellular signal transduction IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q05C16
Protein name Leucine-rich repeat-containing protein 63
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 392 → 449 Leucine rich repeat Repeat
Sequence 
MQKPPLLLRRPLPPKFTKLSLHEKKTHTAKTGKIESLHVAFTEDETTSIKMDRTRFPDVL
RNQSLTPINIQNIFLDHCVQERVTAISSPQKSTKHVREQIPDTATGSIFFPHCNSASTRI
FGKQTNKMESSRKFKTMKDVYTEKRLENILILSSKFSKPKSTPGSVIAQKLEKMHPKHQP
LPESPGYTYQHISRDLSATVPSPPPMTVSMKPEGQWPEHFKSTATLTLRVTEFPGFVSLP
TPVLPRKPHRQSVIETLVTENGNIESVPKQIPPRPPEGLTKTEKIESEIHVVRGEGFKTV
AATRYETITAMTNLAIVNCQVYGRNALNLKGFFILNCPDLTPLAFQLIYLNLSFNDLHYF
PTEILCLKNLQILKLRNNPIKEIPSEIQQLEFLRIFTIAFNLITVLPIGLFSLSYLEELD
VSYNELTFIPNEIQKLRSLEKLTVDGNELSFFPHGILKLNLTKIQFENNFTHPCFWRDNY
LNNPQQLTQIISLFIVQNKLHKFYDKIPVEVQKLLKWGAQFLTELAPLSIYSSRKAITEG
YIAVELPKFEESKNITEGLLTQKRYEEVMVKCINATTVTS
Sequence length 580
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
ATRIAL FIBRILLATION — GWAS catalog 17903304
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLONAL HEMATOPOIESIS — GWAS catalog 37932435
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Atrial Fibrillation Atrial fibrillation Pubtator 17903304 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cardiovascular Diseases Cardiovascular disease Pubtator 17903304 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Heart Failure Heart failure Pubtator 17903304 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only

No strongly related genes found yet for LRRC63.

No additional diseases found yet through genes similar to LRRC63.