LRRC25 (leucine rich repeat containing 25)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 126364
• Gene name: Leucine rich repeat containing 25
• Gene symbol: LRRC25
• Synonyms (NCBI Gene): MAPA
• Chromosome: 19
• Chromosome location: 19p13.11

miRNA Show/Hide all (214)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1119204	hsa-miR-103a	CLIP-seq
MIRT1119205	hsa-miR-107	CLIP-seq
MIRT1119206	hsa-miR-1254	CLIP-seq
MIRT1119207	hsa-miR-1270	CLIP-seq
MIRT1119208	hsa-miR-1827	CLIP-seq
MIRT1119209	hsa-miR-25	CLIP-seq
MIRT1119210	hsa-miR-3065-5p	CLIP-seq
MIRT1119211	hsa-miR-3116	CLIP-seq
MIRT1119212	hsa-miR-3150a-3p	CLIP-seq
MIRT1119213	hsa-miR-3160-3p	CLIP-seq
MIRT1119214	hsa-miR-3175	CLIP-seq
MIRT1119215	hsa-miR-3178	CLIP-seq
MIRT1119216	hsa-miR-32	CLIP-seq
MIRT1119217	hsa-miR-34b	CLIP-seq
MIRT1119218	hsa-miR-3613-3p	CLIP-seq
MIRT1119219	hsa-miR-3614-5p	CLIP-seq
MIRT1119220	hsa-miR-363	CLIP-seq
MIRT1119221	hsa-miR-3664-3p	CLIP-seq
MIRT1119222	hsa-miR-367	CLIP-seq
MIRT1119223	hsa-miR-3677-5p	CLIP-seq
MIRT1119224	hsa-miR-3689a-3p	CLIP-seq
MIRT1119225	hsa-miR-3689c	CLIP-seq
MIRT1119226	hsa-miR-3689d	CLIP-seq
MIRT1119227	hsa-miR-3929	CLIP-seq
MIRT1119228	hsa-miR-4254	CLIP-seq
MIRT1119229	hsa-miR-4270	CLIP-seq
MIRT1119230	hsa-miR-4310	CLIP-seq
MIRT1119231	hsa-miR-4325	CLIP-seq
MIRT1119232	hsa-miR-4328	CLIP-seq
MIRT1119233	hsa-miR-4329	CLIP-seq
MIRT1119234	hsa-miR-4419b	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119236	hsa-miR-4441	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119238	hsa-miR-4478	CLIP-seq
MIRT1119239	hsa-miR-4487	CLIP-seq
MIRT1119240	hsa-miR-4649-3p	CLIP-seq
MIRT1119241	hsa-miR-4683	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT1119243	hsa-miR-4701-5p	CLIP-seq
MIRT1119244	hsa-miR-4722-5p	CLIP-seq
MIRT1119245	hsa-miR-4728-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119247	hsa-miR-4772-5p	CLIP-seq
MIRT1119248	hsa-miR-4786-5p	CLIP-seq
MIRT1119249	hsa-miR-485-5p	CLIP-seq
MIRT1119250	hsa-miR-491-5p	CLIP-seq
MIRT1119251	hsa-miR-495	CLIP-seq
MIRT1119252	hsa-miR-508-5p	CLIP-seq
MIRT1119253	hsa-miR-510	CLIP-seq
MIRT1119254	hsa-miR-512-5p	CLIP-seq
MIRT1119255	hsa-miR-558	CLIP-seq
MIRT1119256	hsa-miR-588	CLIP-seq
MIRT1119257	hsa-miR-607	CLIP-seq
MIRT1119258	hsa-miR-620	CLIP-seq
MIRT1119259	hsa-miR-658	CLIP-seq
MIRT1119260	hsa-miR-665	CLIP-seq
MIRT1119261	hsa-miR-766	CLIP-seq
MIRT1119262	hsa-miR-769-5p	CLIP-seq
MIRT1119263	hsa-miR-92a	CLIP-seq
MIRT1119264	hsa-miR-92b	CLIP-seq
MIRT1119265	hsa-miR-939	CLIP-seq
MIRT1119266	hsa-miR-940	CLIP-seq
MIRT1119204	hsa-miR-103a	CLIP-seq
MIRT1119205	hsa-miR-107	CLIP-seq
MIRT1119208	hsa-miR-1827	CLIP-seq
MIRT1119209	hsa-miR-25	CLIP-seq
MIRT1119213	hsa-miR-3160-3p	CLIP-seq
MIRT1119216	hsa-miR-32	CLIP-seq
MIRT1119217	hsa-miR-34b	CLIP-seq
MIRT1119219	hsa-miR-3614-5p	CLIP-seq
MIRT1119220	hsa-miR-363	CLIP-seq
MIRT1119221	hsa-miR-3664-3p	CLIP-seq
MIRT1119222	hsa-miR-367	CLIP-seq
MIRT2033727	hsa-miR-3926	CLIP-seq
MIRT1119227	hsa-miR-3929	CLIP-seq
MIRT1119230	hsa-miR-4310	CLIP-seq
MIRT1119231	hsa-miR-4325	CLIP-seq
MIRT1119233	hsa-miR-4329	CLIP-seq
MIRT1119234	hsa-miR-4419b	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119238	hsa-miR-4478	CLIP-seq
MIRT1119239	hsa-miR-4487	CLIP-seq
MIRT1119240	hsa-miR-4649-3p	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT2033728	hsa-miR-4718	CLIP-seq
MIRT1119244	hsa-miR-4722-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119248	hsa-miR-4786-5p	CLIP-seq
MIRT1119249	hsa-miR-485-5p	CLIP-seq
MIRT1119253	hsa-miR-510	CLIP-seq
MIRT1119254	hsa-miR-512-5p	CLIP-seq
MIRT2033729	hsa-miR-548s	CLIP-seq
MIRT1119255	hsa-miR-558	CLIP-seq
MIRT1119259	hsa-miR-658	CLIP-seq
MIRT1119260	hsa-miR-665	CLIP-seq
MIRT1119262	hsa-miR-769-5p	CLIP-seq
MIRT1119263	hsa-miR-92a	CLIP-seq
MIRT1119264	hsa-miR-92b	CLIP-seq
MIRT1119266	hsa-miR-940	CLIP-seq
MIRT1119204	hsa-miR-103a	CLIP-seq
MIRT1119205	hsa-miR-107	CLIP-seq
MIRT2264150	hsa-miR-1262	CLIP-seq
MIRT1119208	hsa-miR-1827	CLIP-seq
MIRT1119209	hsa-miR-25	CLIP-seq
MIRT1119213	hsa-miR-3160-3p	CLIP-seq
MIRT1119216	hsa-miR-32	CLIP-seq
MIRT1119217	hsa-miR-34b	CLIP-seq
MIRT1119219	hsa-miR-3614-5p	CLIP-seq
MIRT1119220	hsa-miR-363	CLIP-seq
MIRT1119221	hsa-miR-3664-3p	CLIP-seq
MIRT1119222	hsa-miR-367	CLIP-seq
MIRT1119227	hsa-miR-3929	CLIP-seq
MIRT1119230	hsa-miR-4310	CLIP-seq
MIRT1119231	hsa-miR-4325	CLIP-seq
MIRT1119233	hsa-miR-4329	CLIP-seq
MIRT1119234	hsa-miR-4419b	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119238	hsa-miR-4478	CLIP-seq
MIRT1119239	hsa-miR-4487	CLIP-seq
MIRT1119240	hsa-miR-4649-3p	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT2264151	hsa-miR-4701-3p	CLIP-seq
MIRT1119244	hsa-miR-4722-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119248	hsa-miR-4786-5p	CLIP-seq
MIRT1119249	hsa-miR-485-5p	CLIP-seq
MIRT1119252	hsa-miR-508-5p	CLIP-seq
MIRT1119253	hsa-miR-510	CLIP-seq
MIRT1119254	hsa-miR-512-5p	CLIP-seq
MIRT2264152	hsa-miR-542-3p	CLIP-seq
MIRT1119255	hsa-miR-558	CLIP-seq
MIRT1119259	hsa-miR-658	CLIP-seq
MIRT2264153	hsa-miR-661	CLIP-seq
MIRT1119260	hsa-miR-665	CLIP-seq
MIRT1119261	hsa-miR-766	CLIP-seq
MIRT1119262	hsa-miR-769-5p	CLIP-seq
MIRT1119263	hsa-miR-92a	CLIP-seq
MIRT1119264	hsa-miR-92b	CLIP-seq
MIRT1119266	hsa-miR-940	CLIP-seq
MIRT1119224	hsa-miR-3689a-3p	CLIP-seq
MIRT1119225	hsa-miR-3689c	CLIP-seq
MIRT1119226	hsa-miR-3689d	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119245	hsa-miR-4728-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119248	hsa-miR-4786-5p	CLIP-seq
MIRT1119208	hsa-miR-1827	CLIP-seq
MIRT1119213	hsa-miR-3160-3p	CLIP-seq
MIRT1119217	hsa-miR-34b	CLIP-seq
MIRT1119218	hsa-miR-3613-3p	CLIP-seq
MIRT1119219	hsa-miR-3614-5p	CLIP-seq
MIRT1119224	hsa-miR-3689a-3p	CLIP-seq
MIRT1119225	hsa-miR-3689c	CLIP-seq
MIRT1119226	hsa-miR-3689d	CLIP-seq
MIRT1119233	hsa-miR-4329	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119239	hsa-miR-4487	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT1119244	hsa-miR-4722-5p	CLIP-seq
MIRT1119245	hsa-miR-4728-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119255	hsa-miR-558	CLIP-seq
MIRT1119259	hsa-miR-658	CLIP-seq
MIRT1119260	hsa-miR-665	CLIP-seq
MIRT1119266	hsa-miR-940	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119208	hsa-miR-1827	CLIP-seq
MIRT1119213	hsa-miR-3160-3p	CLIP-seq
MIRT1119217	hsa-miR-34b	CLIP-seq
MIRT1119219	hsa-miR-3614-5p	CLIP-seq
MIRT2563248	hsa-miR-3675-3p	CLIP-seq
MIRT2033727	hsa-miR-3926	CLIP-seq
MIRT1119233	hsa-miR-4329	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119239	hsa-miR-4487	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT1119244	hsa-miR-4722-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119248	hsa-miR-4786-5p	CLIP-seq
MIRT2033729	hsa-miR-548s	CLIP-seq
MIRT1119255	hsa-miR-558	CLIP-seq
MIRT1119259	hsa-miR-658	CLIP-seq
MIRT1119260	hsa-miR-665	CLIP-seq
MIRT1119262	hsa-miR-769-5p	CLIP-seq
MIRT1119266	hsa-miR-940	CLIP-seq
MIRT1119208	hsa-miR-1827	CLIP-seq
MIRT1119213	hsa-miR-3160-3p	CLIP-seq
MIRT1119217	hsa-miR-34b	CLIP-seq
MIRT1119219	hsa-miR-3614-5p	CLIP-seq
MIRT2563248	hsa-miR-3675-3p	CLIP-seq
MIRT2033727	hsa-miR-3926	CLIP-seq
MIRT1119233	hsa-miR-4329	CLIP-seq
MIRT1119235	hsa-miR-4433	CLIP-seq
MIRT1119237	hsa-miR-4459	CLIP-seq
MIRT1119239	hsa-miR-4487	CLIP-seq
MIRT1119242	hsa-miR-4695-5p	CLIP-seq
MIRT1119244	hsa-miR-4722-5p	CLIP-seq
MIRT1119246	hsa-miR-4768-3p	CLIP-seq
MIRT1119248	hsa-miR-4786-5p	CLIP-seq
MIRT2033729	hsa-miR-548s	CLIP-seq
MIRT1119255	hsa-miR-558	CLIP-seq
MIRT1119259	hsa-miR-658	CLIP-seq
MIRT1119260	hsa-miR-665	CLIP-seq
MIRT1119262	hsa-miR-769-5p	CLIP-seq
MIRT1119266	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005829	Component	Cytosol	IDA
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 607518
• HGNC: 29806
• e!Ensembl: ENSG00000175489

Protein

• UniProt ID: Q8N386
• Protein name: Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein)
• Protein function: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo recep
• Tissue specificity: TISSUE SPECIFICITY: Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and
• Sequence:

  MGGTLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGLSLSLPHNQSLRA
  SNVILLDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDGALAARCDLDLQADCNCAL
  ESWHDIRRDNCSGQKPLLCWDTTSSQHNLSAFLEVSCAPGLASATIGAVVVSGCLLLGLA
  IAGPVLAWRLWRCRVARSRELNKPWAAQDGPKPGLGLQPRYGSRSAPKPQVAVPSCPSTP
  DYENMFVGQPAAEHQWDEQGAHPSEDNDFYINYKDIDLASQPVYCNLQSLGQAPMDEEEY
  VIPGH

• Sequence length: 305

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (9)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	35589863, 35851147	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	35851147	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	39406924	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPEREMESIS GRAVIDARUM	—	GWAS catalog	29563502, 36553520	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	37842648	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	38763176	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	28714469, 33536424, 36750564	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	35931864	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	Pubtator	39741278	Associate	★☆☆☆☆ Found in Text Mining only
Hypoxic-Ischemic Encephalopathy	Hypoxic-Ischemic Encephalopathy	BEFREE	31535656		★☆☆☆☆ Found in Text Mining only
Nausea	Nausea	Pubtator	40699388	Associate	★☆☆☆☆ Found in Text Mining only
Varicose Veins	Varicose veins	Pubtator	39341975	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for LRRC25.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRRC25.