LRRC19 (leucine rich repeat containing 19)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 64922
• Gene name: Leucine rich repeat containing 19
• Gene symbol: LRRC19
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9p21.2

miRNA Show/Hide all (134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017683	hsa-miR-335-5p	Microarray	18185580
MIRT1119012	hsa-miR-1183	CLIP-seq
MIRT1119013	hsa-miR-1208	CLIP-seq
MIRT1119014	hsa-miR-1245	CLIP-seq
MIRT1119015	hsa-miR-1251	CLIP-seq
MIRT1119016	hsa-miR-1273e	CLIP-seq
MIRT1119017	hsa-miR-136	CLIP-seq
MIRT1119018	hsa-miR-223	CLIP-seq
MIRT1119019	hsa-miR-2964a-3p	CLIP-seq
MIRT1119020	hsa-miR-302f	CLIP-seq
MIRT1119021	hsa-miR-30a	CLIP-seq
MIRT1119022	hsa-miR-30b	CLIP-seq
MIRT1119023	hsa-miR-30c	CLIP-seq
MIRT1119024	hsa-miR-30d	CLIP-seq
MIRT1119025	hsa-miR-30e	CLIP-seq
MIRT1119026	hsa-miR-323-5p	CLIP-seq
MIRT1119027	hsa-miR-3607-3p	CLIP-seq
MIRT1119028	hsa-miR-3650	CLIP-seq
MIRT1119029	hsa-miR-3686	CLIP-seq
MIRT1119030	hsa-miR-374c	CLIP-seq
MIRT1119031	hsa-miR-4252	CLIP-seq
MIRT1119032	hsa-miR-4459	CLIP-seq
MIRT1119033	hsa-miR-4693-5p	CLIP-seq
MIRT1119034	hsa-miR-4695-5p	CLIP-seq
MIRT1119035	hsa-miR-4697-3p	CLIP-seq
MIRT1119036	hsa-miR-4711-3p	CLIP-seq
MIRT1119037	hsa-miR-4731-3p	CLIP-seq
MIRT1119038	hsa-miR-4742-3p	CLIP-seq
MIRT1119039	hsa-miR-4801	CLIP-seq
MIRT1119040	hsa-miR-486-5p	CLIP-seq
MIRT1119041	hsa-miR-494	CLIP-seq
MIRT1119042	hsa-miR-548p	CLIP-seq
MIRT1119043	hsa-miR-655	CLIP-seq
MIRT1119044	hsa-miR-658	CLIP-seq
MIRT1119045	hsa-miR-665	CLIP-seq
MIRT1119046	hsa-miR-876-3p	CLIP-seq
MIRT1119047	hsa-miR-935	CLIP-seq
MIRT1119015	hsa-miR-1251	CLIP-seq
MIRT2033670	hsa-miR-3192	CLIP-seq
MIRT2033671	hsa-miR-661	CLIP-seq
MIRT2033672	hsa-miR-875-5p	CLIP-seq
MIRT2390336	hsa-miR-3929	CLIP-seq
MIRT2390337	hsa-miR-4419b	CLIP-seq
MIRT2390338	hsa-miR-4478	CLIP-seq
MIRT2390339	hsa-miR-485-5p	CLIP-seq
MIRT2430849	hsa-miR-218	CLIP-seq
MIRT1119020	hsa-miR-302f	CLIP-seq
MIRT2430850	hsa-miR-4289	CLIP-seq
MIRT2430851	hsa-miR-636	CLIP-seq
MIRT2453324	hsa-miR-10a	CLIP-seq
MIRT2453325	hsa-miR-10b	CLIP-seq
MIRT2453326	hsa-miR-339-5p	CLIP-seq
MIRT2453327	hsa-miR-4421	CLIP-seq
MIRT2453328	hsa-miR-4645-5p	CLIP-seq
MIRT2453329	hsa-miR-4662a-5p	CLIP-seq
MIRT2453330	hsa-miR-4673	CLIP-seq
MIRT2453331	hsa-miR-4676-5p	CLIP-seq
MIRT2453332	hsa-miR-4684-5p	CLIP-seq
MIRT2453333	hsa-miR-4755-3p	CLIP-seq
MIRT2453334	hsa-miR-548c-3p	CLIP-seq
MIRT2453335	hsa-miR-575	CLIP-seq
MIRT2453336	hsa-miR-593	CLIP-seq
MIRT2453324	hsa-miR-10a	CLIP-seq
MIRT2453325	hsa-miR-10b	CLIP-seq
MIRT2453326	hsa-miR-339-5p	CLIP-seq
MIRT2453327	hsa-miR-4421	CLIP-seq
MIRT2453329	hsa-miR-4662a-5p	CLIP-seq
MIRT2453331	hsa-miR-4676-5p	CLIP-seq
MIRT2453332	hsa-miR-4684-5p	CLIP-seq
MIRT2453333	hsa-miR-4755-3p	CLIP-seq
MIRT2453334	hsa-miR-548c-3p	CLIP-seq
MIRT2453335	hsa-miR-575	CLIP-seq
MIRT2453336	hsa-miR-593	CLIP-seq
MIRT2453324	hsa-miR-10a	CLIP-seq
MIRT2453325	hsa-miR-10b	CLIP-seq
MIRT1119016	hsa-miR-1273e	CLIP-seq
MIRT1119019	hsa-miR-2964a-3p	CLIP-seq
MIRT1119020	hsa-miR-302f	CLIP-seq
MIRT2563238	hsa-miR-3122	CLIP-seq
MIRT2563239	hsa-miR-3132	CLIP-seq
MIRT1119026	hsa-miR-323-5p	CLIP-seq
MIRT2453326	hsa-miR-339-5p	CLIP-seq
MIRT2563240	hsa-miR-3622b-5p	CLIP-seq
MIRT1119028	hsa-miR-3650	CLIP-seq
MIRT2563241	hsa-miR-3689a-3p	CLIP-seq
MIRT2563242	hsa-miR-3689c	CLIP-seq
MIRT2563243	hsa-miR-3913-5p	CLIP-seq
MIRT2453327	hsa-miR-4421	CLIP-seq
MIRT1119032	hsa-miR-4459	CLIP-seq
MIRT2453328	hsa-miR-4645-5p	CLIP-seq
MIRT2453329	hsa-miR-4662a-5p	CLIP-seq
MIRT2453330	hsa-miR-4673	CLIP-seq
MIRT2453331	hsa-miR-4676-5p	CLIP-seq
MIRT2453332	hsa-miR-4684-5p	CLIP-seq
MIRT1119034	hsa-miR-4695-5p	CLIP-seq
MIRT2563244	hsa-miR-4728-5p	CLIP-seq
MIRT2453333	hsa-miR-4755-3p	CLIP-seq
MIRT2453334	hsa-miR-548c-3p	CLIP-seq
MIRT2453335	hsa-miR-575	CLIP-seq
MIRT2453336	hsa-miR-593	CLIP-seq
MIRT1119044	hsa-miR-658	CLIP-seq
MIRT1119045	hsa-miR-665	CLIP-seq
MIRT1119046	hsa-miR-876-3p	CLIP-seq
MIRT2453324	hsa-miR-10a	CLIP-seq
MIRT2453325	hsa-miR-10b	CLIP-seq
MIRT1119014	hsa-miR-1245	CLIP-seq
MIRT1119016	hsa-miR-1273e	CLIP-seq
MIRT1119019	hsa-miR-2964a-3p	CLIP-seq
MIRT1119020	hsa-miR-302f	CLIP-seq
MIRT2563238	hsa-miR-3122	CLIP-seq
MIRT2563239	hsa-miR-3132	CLIP-seq
MIRT1119026	hsa-miR-323-5p	CLIP-seq
MIRT2453326	hsa-miR-339-5p	CLIP-seq
MIRT2563240	hsa-miR-3622b-5p	CLIP-seq
MIRT1119028	hsa-miR-3650	CLIP-seq
MIRT2563241	hsa-miR-3689a-3p	CLIP-seq
MIRT2563242	hsa-miR-3689c	CLIP-seq
MIRT2563243	hsa-miR-3913-5p	CLIP-seq
MIRT2453327	hsa-miR-4421	CLIP-seq
MIRT1119032	hsa-miR-4459	CLIP-seq
MIRT2453328	hsa-miR-4645-5p	CLIP-seq
MIRT2453329	hsa-miR-4662a-5p	CLIP-seq
MIRT2453330	hsa-miR-4673	CLIP-seq
MIRT2453331	hsa-miR-4676-5p	CLIP-seq
MIRT2453332	hsa-miR-4684-5p	CLIP-seq
MIRT1119034	hsa-miR-4695-5p	CLIP-seq
MIRT2563244	hsa-miR-4728-5p	CLIP-seq
MIRT2453333	hsa-miR-4755-3p	CLIP-seq
MIRT2453334	hsa-miR-548c-3p	CLIP-seq
MIRT2453335	hsa-miR-575	CLIP-seq
MIRT2453336	hsa-miR-593	CLIP-seq
MIRT1119044	hsa-miR-658	CLIP-seq
MIRT1119045	hsa-miR-665	CLIP-seq
MIRT1119046	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IEA
GO:0001817	Process	Regulation of cytokine production	ISS
GO:0002224	Process	Toll-like receptor signaling pathway	IBA
GO:0002224	Process	Toll-like receptor signaling pathway	IEA
GO:0005515	Function	Protein binding	IPI	38172943
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	ISS
GO:0048874	Process	Host-mediated modulation of intestinal microbiota composition	IEA
GO:0048874	Process	Host-mediated modulation of intestinal microbiota composition	ISS
GO:0050727	Process	Regulation of inflammatory response	IEA
GO:0050727	Process	Regulation of inflammatory response	ISS
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IBA
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IDA	19679103
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IEA
GO:1901224	Process	Positive regulation of non-canonical NF-kappaB signal transduction	IEA

Other IDs

• MIM: 619068
• HGNC: 23379
• e!Ensembl: ENSG00000184434

Protein

• UniProt ID: Q9H756
• Protein name: Leucine-rich repeat-containing protein 19
• Protein function: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888). In kidney, prevents infection by uropathog
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	97 → 157	Leucine rich repeat	Repeat
  PF15176	LRR19-TM	256 → 370		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in renal collecting duct epithelial cells. {ECO:0000269|PubMed:25026888}.
• Sequence:

  MKVTGITILFWPLSMILLSDKIQSSKREVQCNFTEKNYTLIPADIKKDVTILDLSYNQIT
  LNGTDTRVLQTYFLLTELYLIENKVTILHNNGFGNLSSLEILNICRNSIYVIQQGAFLGL
  NKLKQLYLCQNKIEQLNADVFVPLRSLKLLNLQGNLISYLDVPPLFHLELITLYGNLWNC
  SCSLFNLQNWLNTSNVTLENENITMCSYPNSLQSYNIKTVPHKAECHSKFPSSVTEDLYI
  HFQPISNSIFNSSSNNLTRNSEHEPLGKSWAFLVGVVVTVLTTSLLIFIAIKCPIWYNIL
  LSYNHHRLEEHEAETYEDGFTGNPSSLSQIPETNSEETTVIFEQLHSFVVDDDGFIEDKY
  IDIHELCEEN

• Sequence length: 370

Related Genes

No strongly related genes found yet for LRRC19.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRRC19.