LRRC15 (leucine rich repeat containing 15)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 131578
• Gene name: Leucine rich repeat containing 15
• Gene symbol: LRRC15
• Synonyms (NCBI Gene): LIB
• Chromosome: 3
• Chromosome location: 3q29

miRNA Show/Hide all (182)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022833	hsa-miR-124-3p	Microarray	18668037
MIRT717920	hsa-miR-4717-5p	HITS-CLIP	19536157
MIRT717919	hsa-miR-1972	HITS-CLIP	19536157
MIRT717918	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT717917	hsa-miR-1266-3p	HITS-CLIP	19536157
MIRT717916	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT717915	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT717914	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT717913	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT656637	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT656636	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT656635	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT656634	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT656633	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT656632	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT656631	hsa-miR-5692a	HITS-CLIP	23824327
MIRT656630	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT656629	hsa-miR-7977	HITS-CLIP	23824327
MIRT656628	hsa-miR-6783-5p	HITS-CLIP	23824327
MIRT656627	hsa-miR-135a-5p	HITS-CLIP	23824327
MIRT656626	hsa-miR-135b-5p	HITS-CLIP	23824327
MIRT656625	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT656624	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT656623	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT656622	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT656620	hsa-miR-6716-5p	HITS-CLIP	23824327
MIRT656621	hsa-miR-299-5p	HITS-CLIP	23824327
MIRT656619	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT656618	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT717920	hsa-miR-4717-5p	HITS-CLIP	19536157
MIRT717919	hsa-miR-1972	HITS-CLIP	19536157
MIRT717918	hsa-miR-4650-5p	HITS-CLIP	19536157
MIRT717917	hsa-miR-1266-3p	HITS-CLIP	19536157
MIRT717916	hsa-miR-150-5p	HITS-CLIP	19536157
MIRT717915	hsa-miR-532-3p	HITS-CLIP	19536157
MIRT717914	hsa-miR-2116-3p	HITS-CLIP	19536157
MIRT717913	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT656637	hsa-miR-548a-3p	HITS-CLIP	23824327
MIRT656636	hsa-miR-548ar-3p	HITS-CLIP	23824327
MIRT656635	hsa-miR-548az-3p	HITS-CLIP	23824327
MIRT656634	hsa-miR-548e-3p	HITS-CLIP	23824327
MIRT656633	hsa-miR-548f-3p	HITS-CLIP	23824327
MIRT656632	hsa-miR-5582-3p	HITS-CLIP	23824327
MIRT656631	hsa-miR-5692a	HITS-CLIP	23824327
MIRT656630	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT656629	hsa-miR-7977	HITS-CLIP	23824327
MIRT656628	hsa-miR-6783-5p	HITS-CLIP	23824327
MIRT656627	hsa-miR-135a-5p	HITS-CLIP	23824327
MIRT656626	hsa-miR-135b-5p	HITS-CLIP	23824327
MIRT656625	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT656624	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT656623	hsa-miR-2115-5p	HITS-CLIP	23824327
MIRT656622	hsa-miR-6815-3p	HITS-CLIP	23824327
MIRT656620	hsa-miR-6716-5p	HITS-CLIP	23824327
MIRT656621	hsa-miR-299-5p	HITS-CLIP	23824327
MIRT656619	hsa-miR-29b-2-5p	HITS-CLIP	23824327
MIRT656618	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT1118894	hsa-miR-103a	CLIP-seq
MIRT1118895	hsa-miR-107	CLIP-seq
MIRT1118896	hsa-miR-3180	CLIP-seq
MIRT1118897	hsa-miR-3180-3p	CLIP-seq
MIRT1118898	hsa-miR-3196	CLIP-seq
MIRT1118899	hsa-miR-3714	CLIP-seq
MIRT1118900	hsa-miR-3919	CLIP-seq
MIRT1118901	hsa-miR-4493	CLIP-seq
MIRT1118902	hsa-miR-4533	CLIP-seq
MIRT1118903	hsa-miR-4690-5p	CLIP-seq
MIRT1118904	hsa-miR-4736	CLIP-seq
MIRT1118905	hsa-miR-490-3p	CLIP-seq
MIRT1118906	hsa-miR-940	CLIP-seq
MIRT1118907	hsa-miR-106a	CLIP-seq
MIRT1118908	hsa-miR-106b	CLIP-seq
MIRT1118909	hsa-miR-1202	CLIP-seq
MIRT1118910	hsa-miR-1207-3p	CLIP-seq
MIRT1118911	hsa-miR-1276	CLIP-seq
MIRT1118912	hsa-miR-1283	CLIP-seq
MIRT1118913	hsa-miR-140-3p	CLIP-seq
MIRT1118914	hsa-miR-140-5p	CLIP-seq
MIRT1118915	hsa-miR-17	CLIP-seq
MIRT1118916	hsa-miR-20a	CLIP-seq
MIRT1118917	hsa-miR-20b	CLIP-seq
MIRT1118918	hsa-miR-22	CLIP-seq
MIRT1118919	hsa-miR-3134	CLIP-seq
MIRT1118920	hsa-miR-3194-5p	CLIP-seq
MIRT1118921	hsa-miR-326	CLIP-seq
MIRT1118922	hsa-miR-330-5p	CLIP-seq
MIRT1118923	hsa-miR-3545-5p	CLIP-seq
MIRT1118924	hsa-miR-3972	CLIP-seq
MIRT1118925	hsa-miR-4434	CLIP-seq
MIRT1118926	hsa-miR-4460	CLIP-seq
MIRT1118927	hsa-miR-4475	CLIP-seq
MIRT1118928	hsa-miR-4477b	CLIP-seq
MIRT1118929	hsa-miR-4516	CLIP-seq
MIRT1118930	hsa-miR-4531	CLIP-seq
MIRT1118931	hsa-miR-4534	CLIP-seq
MIRT1118932	hsa-miR-4640-5p	CLIP-seq
MIRT1118933	hsa-miR-4659a-5p	CLIP-seq
MIRT1118934	hsa-miR-4659b-5p	CLIP-seq
MIRT1118935	hsa-miR-4667-5p	CLIP-seq
MIRT1118936	hsa-miR-4670-3p	CLIP-seq
MIRT1118937	hsa-miR-4700-5p	CLIP-seq
MIRT1118938	hsa-miR-4726-5p	CLIP-seq
MIRT1118939	hsa-miR-4768-5p	CLIP-seq
MIRT1118940	hsa-miR-4776-3p	CLIP-seq
MIRT1118941	hsa-miR-519a	CLIP-seq
MIRT1118942	hsa-miR-519b-3p	CLIP-seq
MIRT1118943	hsa-miR-519c-3p	CLIP-seq
MIRT1118944	hsa-miR-519d	CLIP-seq
MIRT1118945	hsa-miR-520d-5p	CLIP-seq
MIRT1118946	hsa-miR-520g	CLIP-seq
MIRT1118947	hsa-miR-520h	CLIP-seq
MIRT1118948	hsa-miR-524-5p	CLIP-seq
MIRT1118949	hsa-miR-526b	CLIP-seq
MIRT1118950	hsa-miR-548c-3p	CLIP-seq
MIRT1118951	hsa-miR-590-3p	CLIP-seq
MIRT1118952	hsa-miR-637	CLIP-seq
MIRT1118953	hsa-miR-7	CLIP-seq
MIRT1118954	hsa-miR-93	CLIP-seq
MIRT1118911	hsa-miR-1276	CLIP-seq
MIRT2033638	hsa-miR-149	CLIP-seq
MIRT2033639	hsa-miR-185	CLIP-seq
MIRT2033640	hsa-miR-3124-3p	CLIP-seq
MIRT2033641	hsa-miR-3177-3p	CLIP-seq
MIRT2033642	hsa-miR-4306	CLIP-seq
MIRT2033643	hsa-miR-4455	CLIP-seq
MIRT2033644	hsa-miR-4474-3p	CLIP-seq
MIRT2033645	hsa-miR-4488	CLIP-seq
MIRT2033646	hsa-miR-4644	CLIP-seq
MIRT2033647	hsa-miR-4656	CLIP-seq
MIRT1118935	hsa-miR-4667-5p	CLIP-seq
MIRT2033648	hsa-miR-4684-5p	CLIP-seq
MIRT2033649	hsa-miR-4697-5p	CLIP-seq
MIRT1118937	hsa-miR-4700-5p	CLIP-seq
MIRT1118939	hsa-miR-4768-5p	CLIP-seq
MIRT2033650	hsa-miR-604	CLIP-seq
MIRT1118952	hsa-miR-637	CLIP-seq
MIRT2033651	hsa-miR-644	CLIP-seq
MIRT2033652	hsa-miR-647	CLIP-seq
MIRT2033653	hsa-miR-766	CLIP-seq
MIRT2033654	hsa-miR-873	CLIP-seq
MIRT2264090	hsa-miR-1263	CLIP-seq
MIRT2264091	hsa-miR-1294	CLIP-seq
MIRT2033638	hsa-miR-149	CLIP-seq
MIRT2264092	hsa-miR-24	CLIP-seq
MIRT2033641	hsa-miR-3177-3p	CLIP-seq
MIRT2264093	hsa-miR-4284	CLIP-seq
MIRT2033643	hsa-miR-4455	CLIP-seq
MIRT2033644	hsa-miR-4474-3p	CLIP-seq
MIRT2264094	hsa-miR-4502	CLIP-seq
MIRT2264095	hsa-miR-4525	CLIP-seq
MIRT1118904	hsa-miR-4736	CLIP-seq
MIRT2264096	hsa-miR-4762-3p	CLIP-seq
MIRT2264097	hsa-miR-486-3p	CLIP-seq
MIRT2033650	hsa-miR-604	CLIP-seq
MIRT2033651	hsa-miR-644	CLIP-seq
MIRT2033652	hsa-miR-647	CLIP-seq
MIRT2264098	hsa-miR-765	CLIP-seq
MIRT2033648	hsa-miR-4684-5p	CLIP-seq
MIRT2390334	hsa-miR-1207-5p	CLIP-seq
MIRT2033641	hsa-miR-3177-3p	CLIP-seq
MIRT2033643	hsa-miR-4455	CLIP-seq
MIRT2033644	hsa-miR-4474-3p	CLIP-seq
MIRT1118904	hsa-miR-4736	CLIP-seq
MIRT2390335	hsa-miR-4763-3p	CLIP-seq
MIRT2033650	hsa-miR-604	CLIP-seq
MIRT2033651	hsa-miR-644	CLIP-seq
MIRT2033652	hsa-miR-647	CLIP-seq
MIRT2453316	hsa-miR-1233	CLIP-seq
MIRT2453317	hsa-miR-331-3p	CLIP-seq
MIRT2453318	hsa-miR-4279	CLIP-seq
MIRT2453319	hsa-miR-4443	CLIP-seq
MIRT2453320	hsa-miR-4687-5p	CLIP-seq
MIRT2453321	hsa-miR-4691-5p	CLIP-seq
MIRT2264098	hsa-miR-765	CLIP-seq
MIRT2563182	hsa-miR-1290	CLIP-seq
MIRT2563183	hsa-miR-3167	CLIP-seq
MIRT2563184	hsa-miR-330-3p	CLIP-seq
MIRT2563185	hsa-miR-3934	CLIP-seq
MIRT2563186	hsa-miR-431	CLIP-seq
MIRT2563187	hsa-miR-4711-3p	CLIP-seq
MIRT2563188	hsa-miR-552	CLIP-seq
MIRT2563189	hsa-miR-876-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001968	Function	Fibronectin binding	IDA	16098915
GO:0005515	Function	Protein binding	IPI	33961781, 36228039, 36735681, 36757924
GO:0005518	Function	Collagen binding	IDA	16098915
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	36228039, 36735681, 36757924
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	36228039, 36735681, 36757924
GO:0030335	Process	Positive regulation of cell migration	IMP	16098915
GO:0038023	Function	Signaling receptor activity	IBA
GO:0043236	Function	Laminin binding	IDA	16098915
GO:0046597	Process	Host-mediated suppression of symbiont invasion	IDA	36228039, 36757924
GO:0046813	Process	Receptor-mediated virion attachment to host cell	IDA	36228039, 36735681, 36757924
GO:0046813	Process	Receptor-mediated virion attachment to host cell	IMP	18385238
GO:0051965	Process	Positive regulation of synapse assembly	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0098670	Process	Entry receptor-mediated virion attachment to host cell	IDA	32132184, 36228039, 36735681, 36757924
GO:0140311	Function	Protein sequestering activity	IDA	36228039, 36735681, 36757924
GO:1903077	Process	Negative regulation of protein localization to plasma membrane	IMP	18385238

Other IDs

• MIM: 619327
• HGNC: 20818
• e!Ensembl: ENSG00000172061

Protein

• UniProt ID: Q8TF66
• Protein name: Leucine-rich repeat-containing protein 15 (Leucine-rich repeat protein induced by beta-amyloid homolog) (hLib)
• Protein function: (Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13306	LRR_5	66 → 200	BspA type Leucine rich repeat region (6 copies)	Repeat
  PF13855	LRR_8	149 → 209	Leucine rich repeat	Repeat
  PF13855	LRR_8	293 → 353	Leucine rich repeat	Repeat
  PF13855	LRR_8	197 → 257	Leucine rich repeat	Repeat
  PF13855	LRR_8	245 → 305	Leucine rich repeat	Repeat
  PF13855	LRR_8	365 → 424	Leucine rich repeat	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain and placenta (PubMed:11785964). Expressed in lung fibroblasts (PubMed:36228039, PubMed:36757924). Expressed in chodrocytes (PubMed:34702854). {ECO:0000269|PubMed:11785964, ECO:0000269|PubMed:34702854, ECO:0000269|Pub
• Sequence:

  MPLKHYLLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQI
  LNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGL
  FQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNL
  GKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGL
  FHNNHNLQRLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPNLRELWL
  YDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNV
  FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRL
  YDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSVHVPE
  VPSYPETPWYPDTPSYPDTTSVSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLA
  IAAIVIGIVALACSLAACVGCCCCKKRSQAVLMQMKAPNEC

• Sequence length: 581

Related Genes

No strongly related genes found yet for LRRC15.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRRC15.