LRRC14 (leucine rich repeat containing 14)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9684
• Gene name: Leucine rich repeat containing 14
• Gene symbol: LRRC14
• Synonyms (NCBI Gene): LRRC14A
• Chromosome: 8
• Chromosome location: 8q24.3
• Summary: This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

miRNA Show/Hide all (201)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1118842	hsa-miR-1285	CLIP-seq
MIRT1118843	hsa-miR-1291	CLIP-seq
MIRT1118844	hsa-miR-15a	CLIP-seq
MIRT1118845	hsa-miR-15b	CLIP-seq
MIRT1118846	hsa-miR-16	CLIP-seq
MIRT1118847	hsa-miR-195	CLIP-seq
MIRT1118848	hsa-miR-2110	CLIP-seq
MIRT1118849	hsa-miR-2113	CLIP-seq
MIRT1118850	hsa-miR-3153	CLIP-seq
MIRT1118851	hsa-miR-3173-5p	CLIP-seq
MIRT1118852	hsa-miR-3177-5p	CLIP-seq
MIRT1118853	hsa-miR-3187-5p	CLIP-seq
MIRT1118854	hsa-miR-3200-3p	CLIP-seq
MIRT1118855	hsa-miR-3611	CLIP-seq
MIRT1118856	hsa-miR-3660	CLIP-seq
MIRT1118857	hsa-miR-3689a-3p	CLIP-seq
MIRT1118858	hsa-miR-3689c	CLIP-seq
MIRT1118859	hsa-miR-3689d	CLIP-seq
MIRT1118860	hsa-miR-3913-3p	CLIP-seq
MIRT1118861	hsa-miR-424	CLIP-seq
MIRT1118862	hsa-miR-4269	CLIP-seq
MIRT1118863	hsa-miR-4271	CLIP-seq
MIRT1118864	hsa-miR-4438	CLIP-seq
MIRT1118865	hsa-miR-4455	CLIP-seq
MIRT1118866	hsa-miR-4493	CLIP-seq
MIRT1118867	hsa-miR-4514	CLIP-seq
MIRT1118868	hsa-miR-4524	CLIP-seq
MIRT1118869	hsa-miR-4526	CLIP-seq
MIRT1118870	hsa-miR-4645-5p	CLIP-seq
MIRT1118871	hsa-miR-4648	CLIP-seq
MIRT1118872	hsa-miR-4654	CLIP-seq
MIRT1118873	hsa-miR-4667-5p	CLIP-seq
MIRT1118874	hsa-miR-4668-5p	CLIP-seq
MIRT1118875	hsa-miR-4673	CLIP-seq
MIRT1118876	hsa-miR-4687-3p	CLIP-seq
MIRT1118877	hsa-miR-4692	CLIP-seq
MIRT1118878	hsa-miR-4700-5p	CLIP-seq
MIRT1118879	hsa-miR-4725-3p	CLIP-seq
MIRT1118880	hsa-miR-4728-5p	CLIP-seq
MIRT1118881	hsa-miR-4731-5p	CLIP-seq
MIRT1118882	hsa-miR-4733-3p	CLIP-seq
MIRT1118883	hsa-miR-4742-5p	CLIP-seq
MIRT1118884	hsa-miR-4769-5p	CLIP-seq
MIRT1118885	hsa-miR-489	CLIP-seq
MIRT1118886	hsa-miR-497	CLIP-seq
MIRT1118887	hsa-miR-503	CLIP-seq
MIRT1118888	hsa-miR-545	CLIP-seq
MIRT1118889	hsa-miR-583	CLIP-seq
MIRT1118890	hsa-miR-612	CLIP-seq
MIRT1118891	hsa-miR-615-5p	CLIP-seq
MIRT1118892	hsa-miR-646	CLIP-seq
MIRT1118893	hsa-miR-758	CLIP-seq
MIRT2033598	hsa-miR-1207-5p	CLIP-seq
MIRT2033599	hsa-miR-1234	CLIP-seq
MIRT2033600	hsa-miR-1269	CLIP-seq
MIRT2033601	hsa-miR-1269b	CLIP-seq
MIRT2033602	hsa-miR-1825	CLIP-seq
MIRT1118849	hsa-miR-2113	CLIP-seq
MIRT2033603	hsa-miR-214	CLIP-seq
MIRT2033604	hsa-miR-3140-3p	CLIP-seq
MIRT2033605	hsa-miR-3179	CLIP-seq
MIRT2033606	hsa-miR-3202	CLIP-seq
MIRT2033607	hsa-miR-3529	CLIP-seq
MIRT1118855	hsa-miR-3611	CLIP-seq
MIRT2033608	hsa-miR-3619-5p	CLIP-seq
MIRT2033609	hsa-miR-379	CLIP-seq
MIRT2033610	hsa-miR-3908	CLIP-seq
MIRT2033611	hsa-miR-3918	CLIP-seq
MIRT2033612	hsa-miR-3927	CLIP-seq
MIRT2033613	hsa-miR-3936	CLIP-seq
MIRT2033614	hsa-miR-3942-5p	CLIP-seq
MIRT2033615	hsa-miR-4287	CLIP-seq
MIRT2033616	hsa-miR-4476	CLIP-seq
MIRT1118866	hsa-miR-4493	CLIP-seq
MIRT2033617	hsa-miR-4496	CLIP-seq
MIRT2033618	hsa-miR-4512	CLIP-seq
MIRT2033619	hsa-miR-4529-3p	CLIP-seq
MIRT2033620	hsa-miR-4530	CLIP-seq
MIRT2033621	hsa-miR-4533	CLIP-seq
MIRT2033622	hsa-miR-4651	CLIP-seq
MIRT2033623	hsa-miR-4685-3p	CLIP-seq
MIRT2033624	hsa-miR-4703-5p	CLIP-seq
MIRT2033625	hsa-miR-4707-5p	CLIP-seq
MIRT2033626	hsa-miR-4736	CLIP-seq
MIRT2033627	hsa-miR-4743	CLIP-seq
MIRT2033628	hsa-miR-4747-5p	CLIP-seq
MIRT2033629	hsa-miR-4763-3p	CLIP-seq
MIRT2033630	hsa-miR-4766-3p	CLIP-seq
MIRT2033631	hsa-miR-4767	CLIP-seq
MIRT2033632	hsa-miR-4780	CLIP-seq
MIRT2033633	hsa-miR-4802-5p	CLIP-seq
MIRT2033634	hsa-miR-520f	CLIP-seq
MIRT2033635	hsa-miR-608	CLIP-seq
MIRT2033636	hsa-miR-623	CLIP-seq
MIRT1118893	hsa-miR-758	CLIP-seq
MIRT2033637	hsa-miR-761	CLIP-seq
MIRT2033598	hsa-miR-1207-5p	CLIP-seq
MIRT2264042	hsa-miR-1254	CLIP-seq
MIRT2264043	hsa-miR-1273f	CLIP-seq
MIRT2264044	hsa-miR-1294	CLIP-seq
MIRT2264045	hsa-miR-138	CLIP-seq
MIRT2264046	hsa-miR-143	CLIP-seq
MIRT2264047	hsa-miR-148a	CLIP-seq
MIRT2264048	hsa-miR-148b	CLIP-seq
MIRT2264049	hsa-miR-152	CLIP-seq
MIRT2264050	hsa-miR-1909	CLIP-seq
MIRT1118848	hsa-miR-2110	CLIP-seq
MIRT2264051	hsa-miR-298	CLIP-seq
MIRT2264052	hsa-miR-3116	CLIP-seq
MIRT2264053	hsa-miR-3151	CLIP-seq
MIRT2264054	hsa-miR-3157-5p	CLIP-seq
MIRT2264055	hsa-miR-3158-5p	CLIP-seq
MIRT2264056	hsa-miR-3164	CLIP-seq
MIRT2033605	hsa-miR-3179	CLIP-seq
MIRT2264057	hsa-miR-330-3p	CLIP-seq
MIRT2264058	hsa-miR-34a	CLIP-seq
MIRT2264059	hsa-miR-34c-5p	CLIP-seq
MIRT2264060	hsa-miR-3620	CLIP-seq
MIRT2264061	hsa-miR-3929	CLIP-seq
MIRT1118863	hsa-miR-4271	CLIP-seq
MIRT2264062	hsa-miR-4276	CLIP-seq
MIRT2264063	hsa-miR-4299	CLIP-seq
MIRT2264064	hsa-miR-4316	CLIP-seq
MIRT2264065	hsa-miR-4418	CLIP-seq
MIRT2264066	hsa-miR-4419b	CLIP-seq
MIRT2264067	hsa-miR-4422	CLIP-seq
MIRT2264068	hsa-miR-4478	CLIP-seq
MIRT2264069	hsa-miR-449a	CLIP-seq
MIRT2264070	hsa-miR-449b	CLIP-seq
MIRT2033618	hsa-miR-4512	CLIP-seq
MIRT2264071	hsa-miR-4529-5p	CLIP-seq
MIRT2033622	hsa-miR-4651	CLIP-seq
MIRT1118873	hsa-miR-4667-5p	CLIP-seq
MIRT1118874	hsa-miR-4668-5p	CLIP-seq
MIRT2264072	hsa-miR-4691-3p	CLIP-seq
MIRT1118878	hsa-miR-4700-5p	CLIP-seq
MIRT2264073	hsa-miR-4708-3p	CLIP-seq
MIRT2264074	hsa-miR-4708-5p	CLIP-seq
MIRT2264075	hsa-miR-4710	CLIP-seq
MIRT1118879	hsa-miR-4725-3p	CLIP-seq
MIRT1118880	hsa-miR-4728-5p	CLIP-seq
MIRT2264076	hsa-miR-4733-5p	CLIP-seq
MIRT2033626	hsa-miR-4736	CLIP-seq
MIRT2033629	hsa-miR-4763-3p	CLIP-seq
MIRT2264077	hsa-miR-4770	CLIP-seq
MIRT2264078	hsa-miR-4792	CLIP-seq
MIRT2033633	hsa-miR-4802-5p	CLIP-seq
MIRT2264079	hsa-miR-486-3p	CLIP-seq
MIRT2264080	hsa-miR-509-3-5p	CLIP-seq
MIRT2264081	hsa-miR-509-5p	CLIP-seq
MIRT2264082	hsa-miR-512-3p	CLIP-seq
MIRT2264083	hsa-miR-519a	CLIP-seq
MIRT2264084	hsa-miR-519b-3p	CLIP-seq
MIRT2264085	hsa-miR-519c-3p	CLIP-seq
MIRT2264086	hsa-miR-548an	CLIP-seq
MIRT2264087	hsa-miR-570	CLIP-seq
MIRT2033635	hsa-miR-608	CLIP-seq
MIRT2264088	hsa-miR-661	CLIP-seq
MIRT2264089	hsa-miR-873	CLIP-seq
MIRT1118889	hsa-miR-583	CLIP-seq
MIRT2033599	hsa-miR-1234	CLIP-seq
MIRT1118862	hsa-miR-4269	CLIP-seq
MIRT2453314	hsa-miR-4272	CLIP-seq
MIRT1118870	hsa-miR-4645-5p	CLIP-seq
MIRT1118875	hsa-miR-4673	CLIP-seq
MIRT2033625	hsa-miR-4707-5p	CLIP-seq
MIRT2453315	hsa-miR-4719	CLIP-seq
MIRT1118862	hsa-miR-4269	CLIP-seq
MIRT2453314	hsa-miR-4272	CLIP-seq
MIRT1118870	hsa-miR-4645-5p	CLIP-seq
MIRT1118875	hsa-miR-4673	CLIP-seq
MIRT2264072	hsa-miR-4691-3p	CLIP-seq
MIRT2453315	hsa-miR-4719	CLIP-seq
MIRT2563175	hsa-miR-1245b-3p	CLIP-seq
MIRT2264050	hsa-miR-1909	CLIP-seq
MIRT2264054	hsa-miR-3157-5p	CLIP-seq
MIRT2563176	hsa-miR-339-3p	CLIP-seq
MIRT2563177	hsa-miR-383	CLIP-seq
MIRT1118860	hsa-miR-3913-3p	CLIP-seq
MIRT2563178	hsa-miR-4509	CLIP-seq
MIRT2563179	hsa-miR-4532	CLIP-seq
MIRT1118874	hsa-miR-4668-5p	CLIP-seq
MIRT2264072	hsa-miR-4691-3p	CLIP-seq
MIRT2563180	hsa-miR-4744	CLIP-seq
MIRT2563181	hsa-miR-4772-5p	CLIP-seq
MIRT2033633	hsa-miR-4802-5p	CLIP-seq
MIRT1118885	hsa-miR-489	CLIP-seq
MIRT2264083	hsa-miR-519a	CLIP-seq
MIRT2264084	hsa-miR-519b-3p	CLIP-seq
MIRT2264085	hsa-miR-519c-3p	CLIP-seq
MIRT1118891	hsa-miR-615-5p	CLIP-seq
MIRT2264088	hsa-miR-661	CLIP-seq
MIRT2563175	hsa-miR-1245b-3p	CLIP-seq
MIRT2563176	hsa-miR-339-3p	CLIP-seq
MIRT1118860	hsa-miR-3913-3p	CLIP-seq
MIRT2563178	hsa-miR-4509	CLIP-seq
MIRT2563179	hsa-miR-4532	CLIP-seq
MIRT2563180	hsa-miR-4744	CLIP-seq
MIRT1118885	hsa-miR-489	CLIP-seq
MIRT1118891	hsa-miR-615-5p	CLIP-seq
MIRT2264088	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21145461, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	27426725
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0019900	Function	Kinase binding	IBA
GO:0019900	Function	Kinase binding	IPI	27426725
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	27426725
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IBA
GO:0034122	Process	Negative regulation of toll-like receptor signaling pathway	IDA	27426725

Other IDs

• MIM: 619368
• HGNC: 20419
• e!Ensembl: ENSG00000160959

Protein

• UniProt ID: Q15048
• Protein name: Leucine-rich repeat-containing protein 14
• Protein function: Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13516	LRR_6	334 → 351	Leucine Rich repeat	Repeat
  PF13516	LRR_6	221 → 240	Leucine Rich repeat	Repeat

• Sequence:

  MHTLVFLSTRQVLQCQPAACQALPLLPRELFPLLFKVAFMDKKTVVLRELVHTWPFPLLS
  FQQLLQECAHCSRALLQERPSTESMQAVILGLTARLHTSEPGASTQPLCRKHALRVLDMT
  GLLDDGVEQDPGTMSMWDCTAAVARTCIAQQQGGAAEPGPAPIPVEVRVDLRVNRASYAF
  LREALRSSVGSPLRLCCRDLRAEDLPMRNTVALLQLLDAGCLRRVDLRFNNLGLRGLSVI
  IPHVARFQHLASLRLHYVHGDSRQPSVDGEDNFRYFLAQMGRFTCLRELSMGSSLLSGRL
  DQLLSTLQSPLESLELAFCALLPEDLRFLARSPHAAHLKKLDLSGNDLSGSQLAPFQGLL
  QASAATLLHLELTECQLADTQLLATLPILTQCASLRYLGLYGNPLSMAGLKELLRDSVAQ
  AELRTVVHPFPVDCYEGLPWPPPASVLLEASINEEKFARVEAELHQLLLASGRAHVLWTT
  DIYGRLAADYFSL

• Sequence length: 493

Related Genes

No strongly related genes found yet for LRRC14.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRRC14.