LRP3 (LDL receptor related protein 3)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 4037
• Gene name: LDL receptor related protein 3
• Gene symbol: LRP3
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.11

miRNA Show/Hide all (134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048793	hsa-miR-93-5p	CLASH	23622248
MIRT048793	hsa-miR-93-5p	CLASH	23622248
MIRT047679	hsa-miR-10a-5p	CLASH	23622248
MIRT047486	hsa-miR-10b-5p	CLASH	23622248
MIRT043332	hsa-miR-331-3p	CLASH	23622248
MIRT038820	hsa-miR-93-3p	CLASH	23622248
MIRT038820	hsa-miR-93-3p	CLASH	23622248
MIRT038495	hsa-miR-296-3p	CLASH	23622248
MIRT037564	hsa-miR-744-5p	CLASH	23622248
MIRT037564	hsa-miR-744-5p	CLASH	23622248
MIRT491174	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT491173	hsa-miR-6514-5p	PAR-CLIP	23592263
MIRT491172	hsa-miR-4786-5p	PAR-CLIP	23592263
MIRT491171	hsa-miR-769-5p	PAR-CLIP	23592263
MIRT491170	hsa-miR-4481	PAR-CLIP	23592263
MIRT491168	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT491169	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT491167	hsa-miR-4306	PAR-CLIP	23592263
MIRT491166	hsa-miR-4644	PAR-CLIP	23592263
MIRT491165	hsa-miR-504-3p	PAR-CLIP	23592263
MIRT491164	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT491163	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491162	hsa-miR-8085	PAR-CLIP	23592263
MIRT491161	hsa-miR-3175	PAR-CLIP	23592263
MIRT491159	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT491160	hsa-miR-5698	PAR-CLIP	23592263
MIRT491158	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT491157	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT491156	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT491155	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT491154	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491152	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT491153	hsa-miR-4447	PAR-CLIP	23592263
MIRT491151	hsa-miR-4472	PAR-CLIP	23592263
MIRT491150	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT491174	hsa-miR-1296-3p	PAR-CLIP	23592263
MIRT491173	hsa-miR-6514-5p	PAR-CLIP	23592263
MIRT491172	hsa-miR-4786-5p	PAR-CLIP	23592263
MIRT491171	hsa-miR-769-5p	PAR-CLIP	23592263
MIRT491170	hsa-miR-4481	PAR-CLIP	23592263
MIRT491168	hsa-miR-4745-5p	PAR-CLIP	23592263
MIRT491169	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT491167	hsa-miR-4306	PAR-CLIP	23592263
MIRT491166	hsa-miR-4644	PAR-CLIP	23592263
MIRT491165	hsa-miR-504-3p	PAR-CLIP	23592263
MIRT491164	hsa-miR-122-5p	PAR-CLIP	23592263
MIRT491163	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT491162	hsa-miR-8085	PAR-CLIP	23592263
MIRT491161	hsa-miR-3175	PAR-CLIP	23592263
MIRT491159	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT491160	hsa-miR-5698	PAR-CLIP	23592263
MIRT491158	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT491157	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT491156	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT491155	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT491154	hsa-miR-328-5p	PAR-CLIP	23592263
MIRT491152	hsa-miR-6885-5p	PAR-CLIP	23592263
MIRT491153	hsa-miR-4447	PAR-CLIP	23592263
MIRT491151	hsa-miR-4472	PAR-CLIP	23592263
MIRT491150	hsa-miR-7109-5p	PAR-CLIP	23592263
MIRT1118029	hsa-miR-1207-5p	CLIP-seq
MIRT1118030	hsa-miR-1245b-5p	CLIP-seq
MIRT1118031	hsa-miR-1271	CLIP-seq
MIRT1118032	hsa-miR-182	CLIP-seq
MIRT1118033	hsa-miR-3142	CLIP-seq
MIRT1118034	hsa-miR-3938	CLIP-seq
MIRT1118035	hsa-miR-409-5p	CLIP-seq
MIRT1118036	hsa-miR-4253	CLIP-seq
MIRT1118037	hsa-miR-4292	CLIP-seq
MIRT1118038	hsa-miR-4308	CLIP-seq
MIRT1118039	hsa-miR-4435	CLIP-seq
MIRT1118040	hsa-miR-4508	CLIP-seq
MIRT1118041	hsa-miR-4675	CLIP-seq
MIRT1118042	hsa-miR-4688	CLIP-seq
MIRT1118043	hsa-miR-4691-5p	CLIP-seq
MIRT1118044	hsa-miR-4722-5p	CLIP-seq
MIRT1118045	hsa-miR-4726-3p	CLIP-seq
MIRT1118046	hsa-miR-4736	CLIP-seq
MIRT1118047	hsa-miR-4741	CLIP-seq
MIRT1118048	hsa-miR-4763-3p	CLIP-seq
MIRT1118049	hsa-miR-4781-5p	CLIP-seq
MIRT1118050	hsa-miR-520a-5p	CLIP-seq
MIRT1118051	hsa-miR-520d-5p	CLIP-seq
MIRT1118052	hsa-miR-524-5p	CLIP-seq
MIRT1118053	hsa-miR-525-5p	CLIP-seq
MIRT1118054	hsa-miR-630	CLIP-seq
MIRT1118055	hsa-miR-670	CLIP-seq
MIRT1118056	hsa-miR-744	CLIP-seq
MIRT1118057	hsa-miR-892a	CLIP-seq
MIRT1118058	hsa-miR-943	CLIP-seq
MIRT1118059	hsa-miR-96	CLIP-seq
MIRT2033376	hsa-miR-1226	CLIP-seq
MIRT2033377	hsa-miR-1304	CLIP-seq
MIRT2033378	hsa-miR-1910	CLIP-seq
MIRT2033379	hsa-miR-455-3p	CLIP-seq
MIRT2033380	hsa-miR-4713-5p	CLIP-seq
MIRT2033381	hsa-miR-4733-3p	CLIP-seq
MIRT2033382	hsa-miR-942	CLIP-seq
MIRT1118029	hsa-miR-1207-5p	CLIP-seq
MIRT2033376	hsa-miR-1226	CLIP-seq
MIRT2033378	hsa-miR-1910	CLIP-seq
MIRT2263783	hsa-miR-214	CLIP-seq
MIRT2263784	hsa-miR-2467-5p	CLIP-seq
MIRT2263785	hsa-miR-3120-3p	CLIP-seq
MIRT2263786	hsa-miR-3162-3p	CLIP-seq
MIRT2263787	hsa-miR-329	CLIP-seq
MIRT2263788	hsa-miR-3619-5p	CLIP-seq
MIRT2263789	hsa-miR-362-3p	CLIP-seq
MIRT1118034	hsa-miR-3938	CLIP-seq
MIRT1118035	hsa-miR-409-5p	CLIP-seq
MIRT2263790	hsa-miR-4264	CLIP-seq
MIRT2263791	hsa-miR-4269	CLIP-seq
MIRT2263792	hsa-miR-4278	CLIP-seq
MIRT1118037	hsa-miR-4292	CLIP-seq
MIRT1118038	hsa-miR-4308	CLIP-seq
MIRT1118040	hsa-miR-4508	CLIP-seq
MIRT2033379	hsa-miR-455-3p	CLIP-seq
MIRT2263793	hsa-miR-4660	CLIP-seq
MIRT1118041	hsa-miR-4675	CLIP-seq
MIRT2263794	hsa-miR-4690-5p	CLIP-seq
MIRT2263795	hsa-miR-4695-5p	CLIP-seq
MIRT2033381	hsa-miR-4733-3p	CLIP-seq
MIRT1118047	hsa-miR-4741	CLIP-seq
MIRT1118048	hsa-miR-4763-3p	CLIP-seq
MIRT1118049	hsa-miR-4781-5p	CLIP-seq
MIRT2263796	hsa-miR-489	CLIP-seq
MIRT1118051	hsa-miR-520d-5p	CLIP-seq
MIRT1118052	hsa-miR-524-5p	CLIP-seq
MIRT1118054	hsa-miR-630	CLIP-seq
MIRT1118055	hsa-miR-670	CLIP-seq
MIRT1118056	hsa-miR-744	CLIP-seq
MIRT2263797	hsa-miR-761	CLIP-seq
MIRT1118057	hsa-miR-892a	CLIP-seq
MIRT1118058	hsa-miR-943	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0005905	Component	Clathrin-coated pit	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0006898	Process	Receptor-mediated endocytosis	TAS	9693042
GO:0010628	Process	Positive regulation of gene expression	IMP	28340487
GO:0010629	Process	Negative regulation of gene expression	IMP	28340487
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9693042
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0045599	Process	Negative regulation of fat cell differentiation	IMP	28340487
GO:0045669	Process	Positive regulation of osteoblast differentiation	IMP	28340487
GO:0150104	Process	Transport across blood-brain barrier	NAS	30280653

Other IDs

• MIM: 603159
• HGNC: 6695
• e!Ensembl: ENSG00000130881

Protein

• UniProt ID: O75074
• Protein name: Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105)
• Protein function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00057	Ldl_recept_a	453 → 489	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	164 → 200	Low-density lipoprotein receptor domain class A	Repeat
  PF00057	Ldl_recept_a	210 → 249	Low-density lipoprotein receptor domain class A	Repeat
  PF00431	CUB	43 → 156	CUB domain	Domain
  PF00431	CUB	254 → 362	CUB domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte. {ECO:0000269|PubMed:96930
• Sequence:

  MEKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSP
  AWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSLDWLLLGPAAPPRQEAFRLC
  GSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQADEFRCDNGKCLP
  GPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDC
  GDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDSRRVLLQLEL
  RLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAGHGFNA
  TYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPACPPDQ
  YPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDC
  QDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRAFETQMTRL
  EAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTAMRRQMRRHASRRGPS
  RRRLGRLWNRLFHRPRAPRGQIPLLTAARPSQTVLGDGFLQPAPGAAPDPPAPLMDTGST
  RAAGDRPPSAPGRAPEVGPSGPPLPSGLRDPECRPVDKDRKVCREPLVDGPAPADAPREP
  CSAQDPHPQVSTASSTLGPHSPEPLGVCRNPPPPCSPMLEASDDEALLVC

• Sequence length: 770

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes

No strongly related genes found yet for LRP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRP3.