LRFN4 (leucine rich repeat and fibronectin type III domain containing 4)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 78999
• Gene name: Leucine rich repeat and fibronectin type III domain containing 4
• Gene symbol: LRFN4
• Synonyms (NCBI Gene): FIGLER6, SALM3, SALM3.
• Chromosome: 11
• Chromosome location: 11q13.2

miRNA Show/Hide all (47)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027568	hsa-miR-98-5p	Microarray	19088304
MIRT1117523	hsa-let-7a	CLIP-seq
MIRT1117524	hsa-let-7b	CLIP-seq
MIRT1117525	hsa-let-7c	CLIP-seq
MIRT1117526	hsa-let-7d	CLIP-seq
MIRT1117527	hsa-let-7e	CLIP-seq
MIRT1117528	hsa-let-7f	CLIP-seq
MIRT1117529	hsa-let-7g	CLIP-seq
MIRT1117530	hsa-let-7i	CLIP-seq
MIRT1117531	hsa-miR-1293	CLIP-seq
MIRT1117532	hsa-miR-202	CLIP-seq
MIRT1117533	hsa-miR-340	CLIP-seq
MIRT1117534	hsa-miR-3657	CLIP-seq
MIRT1117535	hsa-miR-4251	CLIP-seq
MIRT1117536	hsa-miR-4293	CLIP-seq
MIRT1117537	hsa-miR-4432	CLIP-seq
MIRT1117538	hsa-miR-4458	CLIP-seq
MIRT1117539	hsa-miR-4483	CLIP-seq
MIRT1117540	hsa-miR-4500	CLIP-seq
MIRT1117541	hsa-miR-4795-3p	CLIP-seq
MIRT1117542	hsa-miR-544b	CLIP-seq
MIRT1117543	hsa-miR-548ac	CLIP-seq
MIRT1117544	hsa-miR-548ae	CLIP-seq
MIRT1117545	hsa-miR-548aj	CLIP-seq
MIRT1117546	hsa-miR-548am	CLIP-seq
MIRT1117547	hsa-miR-548d-3p	CLIP-seq
MIRT1117548	hsa-miR-548x	CLIP-seq
MIRT1117549	hsa-miR-548z	CLIP-seq
MIRT1117550	hsa-miR-580	CLIP-seq
MIRT1117551	hsa-miR-590-3p	CLIP-seq
MIRT1117552	hsa-miR-604	CLIP-seq
MIRT1117553	hsa-miR-647	CLIP-seq
MIRT1117554	hsa-miR-939	CLIP-seq
MIRT1117555	hsa-miR-98	CLIP-seq
MIRT2033199	hsa-miR-188-5p	CLIP-seq
MIRT2033200	hsa-miR-22	CLIP-seq
MIRT1117535	hsa-miR-4251	CLIP-seq
MIRT2263529	hsa-miR-548aa	CLIP-seq
MIRT1117543	hsa-miR-548ac	CLIP-seq
MIRT1117544	hsa-miR-548ae	CLIP-seq
MIRT1117545	hsa-miR-548aj	CLIP-seq
MIRT1117546	hsa-miR-548am	CLIP-seq
MIRT1117547	hsa-miR-548d-3p	CLIP-seq
MIRT1117548	hsa-miR-548x	CLIP-seq
MIRT1117549	hsa-miR-548z	CLIP-seq
MIRT1117550	hsa-miR-580	CLIP-seq
MIRT2438435	hsa-miR-4443	CLIP-seq

Gene ontology (GO) Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005886	Component	Plasma membrane	TAS
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IEA
GO:0016020	Component	Membrane	IEA
GO:0098839	Component	Postsynaptic density membrane	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IBA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099151	Process	Regulation of postsynaptic density assembly	IBA
GO:0099151	Process	Regulation of postsynaptic density assembly	IEA
GO:0099560	Process	Synaptic membrane adhesion	IBA
GO:0099560	Process	Synaptic membrane adhesion	IEA
GO:1905606	Process	Regulation of presynapse assembly	IBA
GO:1905606	Process	Regulation of presynapse assembly	IEA

Other IDs

• MIM: 612810
• HGNC: 28456
• e!Ensembl: ENSG00000173621

Protein

• UniProt ID: Q6PJG9
• Protein name: Leucine-rich repeat and fibronectin type-III domain-containing protein 4
• Protein function: Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00041	fn3	407 → 484	Fibronectin type III domain	Domain
  PF07679	I-set	281 → 368	Immunoglobulin I-set domain	Domain
  PF13855	LRR_8	48 → 108	Leucine rich repeat	Repeat
  PF13855	LRR_8	120 → 181	Leucine rich repeat	Repeat
  PF13855	LRR_8	96 → 157	Leucine rich repeat	Repeat
  PF13855	LRR_8	169 → 214	Leucine rich repeat	Repeat

• Sequence:

  MAPPLLLLLLASGAAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFI
  QALGPPDFRNMTGLVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPV
  NLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIGAMPALHTLNLDHNL
  IDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSFSGNPLHCNC
  ELLWLRRLARPDDLETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATL
  RCRALGDPAPTMHWVGPDDRLVGNSSRARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEA
  TARVELRVLALPHGGNSSAEGGRPGPSDIAASARTAAEGEGTLESEPAVQVTEVTATSGL
  VSWGPGRPADPVWMFQIQYNSSEDETLIYRIVPASSHHFLLKHLVPGADYDLCLLALSPA
  AGPSDLTATRLLGCAHFSTLPASPLCHALQAHVLGGTLTVAVGGVLVAALLVFTVALLVR
  GRGAGNGRLPLKLSHVQSQTNGGPSPTPKAHPPRSPPPRPQRSCSLDLGDAGCYGYARRL
  GGAWARRSHSVHGGLLGAGCRGVGGSAERLEESVV

• Sequence length: 635

Pathways

Reactome Pathway:

Synaptic adhesion-like molecules

Related Genes

No strongly related genes found yet for LRFN4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRFN4.