LRCH4 (leucine rich repeats and calponin homology domain containing 4)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 4034
• Gene name: Leucine rich repeats and calponin homology domain containing 4
• Gene symbol: LRCH4
• Synonyms (NCBI Gene): LRN, LRRN1, LRRN4, PP14183
• Chromosome: 7
• Chromosome location: 7q22.1
• Summary: This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded prot

miRNA Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT042268	hsa-miR-484	CLASH	23622248
MIRT038138	hsa-miR-423-5p	CLASH	23622248
MIRT440315	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440315	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT1117426	hsa-miR-1182	CLIP-seq
MIRT1117427	hsa-miR-1207-5p	CLIP-seq
MIRT1117428	hsa-miR-1275	CLIP-seq
MIRT1117429	hsa-miR-1283	CLIP-seq
MIRT1117430	hsa-miR-1321	CLIP-seq
MIRT1117431	hsa-miR-15a	CLIP-seq
MIRT1117432	hsa-miR-15b	CLIP-seq
MIRT1117433	hsa-miR-16	CLIP-seq
MIRT1117434	hsa-miR-1908	CLIP-seq
MIRT1117435	hsa-miR-1915	CLIP-seq
MIRT1117436	hsa-miR-195	CLIP-seq
MIRT1117437	hsa-miR-197	CLIP-seq
MIRT1117438	hsa-miR-1972	CLIP-seq
MIRT1117439	hsa-miR-3121-3p	CLIP-seq
MIRT1117440	hsa-miR-3126-5p	CLIP-seq
MIRT1117441	hsa-miR-3147	CLIP-seq
MIRT1117442	hsa-miR-3151	CLIP-seq
MIRT1117443	hsa-miR-3153	CLIP-seq
MIRT1117444	hsa-miR-3179	CLIP-seq
MIRT1117445	hsa-miR-3183	CLIP-seq
MIRT1117446	hsa-miR-3202	CLIP-seq
MIRT1117447	hsa-miR-3611	CLIP-seq
MIRT1117448	hsa-miR-3616-3p	CLIP-seq
MIRT1117449	hsa-miR-3918	CLIP-seq
MIRT1117450	hsa-miR-3921	CLIP-seq
MIRT1117451	hsa-miR-3936	CLIP-seq
MIRT1117452	hsa-miR-3943	CLIP-seq
MIRT1117453	hsa-miR-3976	CLIP-seq
MIRT1117454	hsa-miR-424	CLIP-seq
MIRT1117455	hsa-miR-4271	CLIP-seq
MIRT1117456	hsa-miR-4302	CLIP-seq
MIRT1117457	hsa-miR-4323	CLIP-seq
MIRT1117458	hsa-miR-4419a	CLIP-seq
MIRT1117459	hsa-miR-4425	CLIP-seq
MIRT1117460	hsa-miR-4459	CLIP-seq
MIRT738725	hsa-miR-4468	CLIP-seq
MIRT1117461	hsa-miR-4481	CLIP-seq
MIRT1117462	hsa-miR-4488	CLIP-seq
MIRT1117463	hsa-miR-4493	CLIP-seq
MIRT1117464	hsa-miR-4510	CLIP-seq
MIRT1117465	hsa-miR-4524	CLIP-seq
MIRT1117466	hsa-miR-4649-3p	CLIP-seq
MIRT1117467	hsa-miR-4653-5p	CLIP-seq
MIRT1117468	hsa-miR-4665-5p	CLIP-seq
MIRT1117469	hsa-miR-4667-5p	CLIP-seq
MIRT1117470	hsa-miR-4672	CLIP-seq
MIRT1117471	hsa-miR-4677-3p	CLIP-seq
MIRT1117472	hsa-miR-4679	CLIP-seq
MIRT1117473	hsa-miR-4684-5p	CLIP-seq
MIRT1117474	hsa-miR-4697-3p	CLIP-seq
MIRT1117475	hsa-miR-4697-5p	CLIP-seq
MIRT1117476	hsa-miR-4700-5p	CLIP-seq
MIRT1117477	hsa-miR-4706	CLIP-seq
MIRT1117478	hsa-miR-4710	CLIP-seq
MIRT1117479	hsa-miR-4717-5p	CLIP-seq
MIRT1117480	hsa-miR-4723-3p	CLIP-seq
MIRT1117481	hsa-miR-4725-3p	CLIP-seq
MIRT1117482	hsa-miR-4728-5p	CLIP-seq
MIRT1117483	hsa-miR-4731-5p	CLIP-seq
MIRT1117484	hsa-miR-4739	CLIP-seq
MIRT1117485	hsa-miR-4745-5p	CLIP-seq
MIRT1117486	hsa-miR-4747-5p	CLIP-seq
MIRT1117487	hsa-miR-4749-5p	CLIP-seq
MIRT1117488	hsa-miR-4756-3p	CLIP-seq
MIRT1117489	hsa-miR-4756-5p	CLIP-seq
MIRT1117490	hsa-miR-4757-5p	CLIP-seq
MIRT1117491	hsa-miR-4763-3p	CLIP-seq
MIRT1117492	hsa-miR-4789-5p	CLIP-seq
MIRT1117493	hsa-miR-497	CLIP-seq
MIRT1117494	hsa-miR-503	CLIP-seq
MIRT1117495	hsa-miR-582-5p	CLIP-seq
MIRT1117496	hsa-miR-625	CLIP-seq
MIRT1117497	hsa-miR-637	CLIP-seq
MIRT1117498	hsa-miR-646	CLIP-seq
MIRT1117499	hsa-miR-663	CLIP-seq
MIRT1117500	hsa-miR-759	CLIP-seq
MIRT1117430	hsa-miR-1321	CLIP-seq
MIRT1117458	hsa-miR-4419a	CLIP-seq
MIRT1117464	hsa-miR-4510	CLIP-seq
MIRT1117484	hsa-miR-4739	CLIP-seq
MIRT1117489	hsa-miR-4756-5p	CLIP-seq
MIRT738725	hsa-miR-4468	CLIP-seq
MIRT1117427	hsa-miR-1207-5p	CLIP-seq
MIRT2033157	hsa-miR-124	CLIP-seq
MIRT2033158	hsa-miR-1243	CLIP-seq
MIRT2033159	hsa-miR-1273c	CLIP-seq
MIRT1117430	hsa-miR-1321	CLIP-seq
MIRT2033160	hsa-miR-1827	CLIP-seq
MIRT1117434	hsa-miR-1908	CLIP-seq
MIRT2033161	hsa-miR-1909	CLIP-seq
MIRT2033162	hsa-miR-1912	CLIP-seq
MIRT2033163	hsa-miR-296-5p	CLIP-seq
MIRT2033164	hsa-miR-3065-3p	CLIP-seq
MIRT2033165	hsa-miR-3144-5p	CLIP-seq
MIRT1117442	hsa-miR-3151	CLIP-seq
MIRT1117444	hsa-miR-3179	CLIP-seq
MIRT2033166	hsa-miR-3191	CLIP-seq
MIRT2033167	hsa-miR-340	CLIP-seq
MIRT1117448	hsa-miR-3616-3p	CLIP-seq
MIRT2033168	hsa-miR-3649	CLIP-seq
MIRT2033169	hsa-miR-3654	CLIP-seq
MIRT2033170	hsa-miR-3665	CLIP-seq
MIRT2033171	hsa-miR-3667-3p	CLIP-seq
MIRT2033172	hsa-miR-3677-3p	CLIP-seq
MIRT2033173	hsa-miR-3683	CLIP-seq
MIRT1117449	hsa-miR-3918	CLIP-seq
MIRT2033174	hsa-miR-4260	CLIP-seq
MIRT2033175	hsa-miR-4281	CLIP-seq
MIRT2033176	hsa-miR-4283	CLIP-seq
MIRT1117458	hsa-miR-4419a	CLIP-seq
MIRT2033177	hsa-miR-4436b-3p	CLIP-seq
MIRT2033178	hsa-miR-4462	CLIP-seq
MIRT2033179	hsa-miR-4489	CLIP-seq
MIRT1117463	hsa-miR-4493	CLIP-seq
MIRT1117464	hsa-miR-4510	CLIP-seq
MIRT2033180	hsa-miR-4532	CLIP-seq
MIRT2033181	hsa-miR-4636	CLIP-seq
MIRT2033182	hsa-miR-4652-5p	CLIP-seq
MIRT2033183	hsa-miR-4656	CLIP-seq
MIRT1117470	hsa-miR-4672	CLIP-seq
MIRT2033184	hsa-miR-4688	CLIP-seq
MIRT1117477	hsa-miR-4706	CLIP-seq
MIRT2033185	hsa-miR-4711-3p	CLIP-seq
MIRT1117484	hsa-miR-4739	CLIP-seq
MIRT1117487	hsa-miR-4749-5p	CLIP-seq
MIRT1117488	hsa-miR-4756-3p	CLIP-seq
MIRT1117489	hsa-miR-4756-5p	CLIP-seq
MIRT1117491	hsa-miR-4763-3p	CLIP-seq
MIRT1117492	hsa-miR-4789-5p	CLIP-seq
MIRT2033186	hsa-miR-4797-5p	CLIP-seq
MIRT2033187	hsa-miR-485-5p	CLIP-seq
MIRT2033188	hsa-miR-486-3p	CLIP-seq
MIRT2033189	hsa-miR-491-5p	CLIP-seq
MIRT2033190	hsa-miR-506	CLIP-seq
MIRT2033191	hsa-miR-511	CLIP-seq
MIRT2033192	hsa-miR-541	CLIP-seq
MIRT2033193	hsa-miR-551a	CLIP-seq
MIRT2033194	hsa-miR-551b	CLIP-seq
MIRT1117495	hsa-miR-582-5p	CLIP-seq
MIRT2033195	hsa-miR-615-5p	CLIP-seq
MIRT1117497	hsa-miR-637	CLIP-seq
MIRT2033196	hsa-miR-654-5p	CLIP-seq
MIRT2033197	hsa-miR-659	CLIP-seq
MIRT1117499	hsa-miR-663	CLIP-seq
MIRT2033198	hsa-miR-9	CLIP-seq
MIRT1117427	hsa-miR-1207-5p	CLIP-seq
MIRT2033157	hsa-miR-124	CLIP-seq
MIRT2263519	hsa-miR-128	CLIP-seq
MIRT1117434	hsa-miR-1908	CLIP-seq
MIRT2033163	hsa-miR-296-5p	CLIP-seq
MIRT1117442	hsa-miR-3151	CLIP-seq
MIRT1117444	hsa-miR-3179	CLIP-seq
MIRT1117446	hsa-miR-3202	CLIP-seq
MIRT2033176	hsa-miR-4283	CLIP-seq
MIRT2033179	hsa-miR-4489	CLIP-seq
MIRT1117463	hsa-miR-4493	CLIP-seq
MIRT1117470	hsa-miR-4672	CLIP-seq
MIRT1117488	hsa-miR-4756-3p	CLIP-seq
MIRT1117491	hsa-miR-4763-3p	CLIP-seq
MIRT1117492	hsa-miR-4789-5p	CLIP-seq
MIRT2033190	hsa-miR-506	CLIP-seq
MIRT2033192	hsa-miR-541	CLIP-seq
MIRT1117495	hsa-miR-582-5p	CLIP-seq
MIRT2033196	hsa-miR-654-5p	CLIP-seq
MIRT1117499	hsa-miR-663	CLIP-seq
MIRT1117427	hsa-miR-1207-5p	CLIP-seq
MIRT2033159	hsa-miR-1273c	CLIP-seq
MIRT2033173	hsa-miR-3683	CLIP-seq
MIRT2033178	hsa-miR-4462	CLIP-seq
MIRT2390318	hsa-miR-4514	CLIP-seq
MIRT2390319	hsa-miR-4692	CLIP-seq
MIRT1117491	hsa-miR-4763-3p	CLIP-seq
MIRT738725	hsa-miR-4468	CLIP-seq
MIRT738725	hsa-miR-4468	CLIP-seq
MIRT738725	hsa-miR-4468	CLIP-seq

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001765	Process	Membrane raft assembly	IEA
GO:0001765	Process	Membrane raft assembly	ISS
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 24255178, 25416956, 32203420, 32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0007399	Process	Nervous system development	TAS	9799793
GO:0016020	Component	Membrane	IEA
GO:0016605	Component	PML body	IBA
GO:0016605	Component	PML body	IDA
GO:0034123	Process	Positive regulation of toll-like receptor signaling pathway	IEA
GO:0034123	Process	Positive regulation of toll-like receptor signaling pathway	ISS

Other IDs

• MIM: 620165
• HGNC: 6691
• e!Ensembl: ENSG00000077454

Protein

• UniProt ID: O75427
• Protein name: Leucine-rich repeat and calponin homology domain-containing protein 4 (Leucine-rich repeat neuronal protein 4) (Leucine-rich neuronal protein)
• Protein function: Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	535 → 641	Calponin homology (CH) domain	Domain
  PF13855	LRR_8	137 → 194	Leucine rich repeat	Repeat
  PF13855	LRR_8	68 → 126	Leucine rich repeat	Repeat

• Sequence:

  MAAAVAAPLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRG
  AARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLN
  LSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCG
  LSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQ
  SPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDS
  GFHSVDSGSKRWSGNESTDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSH
  VPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERERRQQQ
  QSGAWGAPRKDSLLKPGLRAVVGGAAAVSTQAMHNGSPKSSASQAGAAAGQGAPAPAPAS
  QEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDL
  MTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKA
  RKNVESFLEACRKMGVPEADLCSPSDLLQGTARGLRTALEAVKRVGGKALPPLWPPSGLG
  GFVVFYVVLMLLLYVTYTRLLGS

• Sequence length: 683

Related Genes

No strongly related genes found yet for LRCH4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRCH4.