LRCH3 (leucine rich repeats and calponin homology domain containing 3)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84859
• Gene name: Leucine rich repeats and calponin homology domain containing 3
• Gene symbol: LRCH3
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q29

miRNA Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044498	hsa-miR-320a	CLASH	23622248
MIRT643498	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT661869	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT643497	hsa-miR-3917	HITS-CLIP	23824327
MIRT643496	hsa-miR-3615	HITS-CLIP	23824327
MIRT643495	hsa-miR-6089	HITS-CLIP	23824327
MIRT636455	hsa-miR-1267	HITS-CLIP	23824327
MIRT636454	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT636446	hsa-miR-3944-5p	HITS-CLIP	23824327
MIRT636442	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT643498	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT643497	hsa-miR-3917	HITS-CLIP	23824327
MIRT643496	hsa-miR-3615	HITS-CLIP	23824327
MIRT643495	hsa-miR-6089	HITS-CLIP	23824327
MIRT643494	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT643493	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT643492	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT643491	hsa-miR-4257	HITS-CLIP	23824327
MIRT643490	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT636460	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT636459	hsa-miR-1183	HITS-CLIP	23824327
MIRT636458	hsa-miR-1208	HITS-CLIP	23824327
MIRT636457	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT636456	hsa-miR-3137	HITS-CLIP	23824327
MIRT636455	hsa-miR-1267	HITS-CLIP	23824327
MIRT636454	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT636453	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT636452	hsa-miR-3135b	HITS-CLIP	23824327
MIRT636451	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT636450	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT636449	hsa-miR-4284	HITS-CLIP	23824327
MIRT636448	hsa-miR-3652	HITS-CLIP	23824327
MIRT636447	hsa-miR-4430	HITS-CLIP	23824327
MIRT636446	hsa-miR-3944-5p	HITS-CLIP	23824327
MIRT636445	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT636444	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT636443	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT636442	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT636441	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT636440	hsa-miR-5698	HITS-CLIP	23824327
MIRT643498	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT661869	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT643497	hsa-miR-3917	HITS-CLIP	23824327
MIRT643496	hsa-miR-3615	HITS-CLIP	23824327
MIRT643495	hsa-miR-6089	HITS-CLIP	23824327
MIRT636455	hsa-miR-1267	HITS-CLIP	23824327
MIRT636454	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT636446	hsa-miR-3944-5p	HITS-CLIP	23824327
MIRT636442	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT643498	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT643497	hsa-miR-3917	HITS-CLIP	23824327
MIRT643496	hsa-miR-3615	HITS-CLIP	23824327
MIRT643495	hsa-miR-6089	HITS-CLIP	23824327
MIRT643494	hsa-miR-6871-3p	HITS-CLIP	23824327
MIRT643493	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT643492	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT643491	hsa-miR-4257	HITS-CLIP	23824327
MIRT643490	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT636460	hsa-miR-3664-5p	HITS-CLIP	23824327
MIRT636459	hsa-miR-1183	HITS-CLIP	23824327
MIRT636458	hsa-miR-1208	HITS-CLIP	23824327
MIRT636457	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT636456	hsa-miR-3137	HITS-CLIP	23824327
MIRT636455	hsa-miR-1267	HITS-CLIP	23824327
MIRT636454	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT636453	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT636452	hsa-miR-3135b	HITS-CLIP	23824327
MIRT636451	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT636450	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT636449	hsa-miR-4284	HITS-CLIP	23824327
MIRT636448	hsa-miR-3652	HITS-CLIP	23824327
MIRT636447	hsa-miR-4430	HITS-CLIP	23824327
MIRT636446	hsa-miR-3944-5p	HITS-CLIP	23824327
MIRT636445	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT636444	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT636443	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT636442	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT636441	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT636440	hsa-miR-5698	HITS-CLIP	23824327
MIRT1117417	hsa-miR-218	CLIP-seq
MIRT1117418	hsa-miR-3119	CLIP-seq
MIRT1117419	hsa-miR-3653	CLIP-seq
MIRT1117420	hsa-miR-3658	CLIP-seq
MIRT1117421	hsa-miR-4502	CLIP-seq
MIRT1117422	hsa-miR-4662a-5p	CLIP-seq
MIRT1117423	hsa-miR-495	CLIP-seq
MIRT1117424	hsa-miR-636	CLIP-seq
MIRT1117425	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (6)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24255178, 25416956, 29467281, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IC	29467281
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0032185	Process	Septin cytoskeleton organization	IMP	29467281

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q96II8
• Protein name: DISP complex protein LRCH3 (Leucine-rich repeat and calponin homology domain-containing protein 3)
• Protein function: As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	652 → 766	Calponin homology (CH) domain	Domain
  PF13855	LRR_8	151 → 208	Leucine rich repeat	Repeat
  PF13855	LRR_8	84 → 140	Leucine rich repeat	Repeat

• Sequence:

  MAAAGLVAVAAAAEYSGTVASGGNLPGVHCGPSSGAGPGFGPGSWSRSLDRALEEAAVTG
  VLSLSGRKLREFPRGAANHDLTDTTRADLSRNRLSEIPIEACHFVSLENLNLYQNCIRYI
  PEAILNLQALTFLNISRNQLSTLPVHLCNLPLKVLIASNNKLVSLPEEIGHLRHLMELDV
  SCNEIQTIPSQIGNLEALRDLNVRRNHLVHLPEELAELPLIRLDFSCNKITTIPVCYRNL
  RHLQTITLDNNPLQSPPAQICIKGKVHIFKYLNIQACKIAPDLPDYDRRPLGFGSCHEEL
  YSSRPYGALDSGFNSVDSGDKRWSGNEPTDEFSDLPLRVAEITKEQRLRRESQYQENRGS
  LVVTNGGVEHDLDQIDYIDSCTAEEEEAEVRQPKGPDPDSLSSQFMAYIEQRRISHEGSP
  VKPVAIREFQKTEDMRRYLHQNRVPAEPSSLLSLSASHNQLSHTDLELHQRREQLVERTR
  REAQLAALQYEEEKIRTKQIQRDAVLDFVKQKASQSPQKQHPLLDGVDGECPFPSRRSQH
  TDDSALCMSLSGLNQVGCAATLPHSSAFTPLKSDDRPNALLSSPATETVHHSPAYSFPAA
  IQRNQPQRPESFLFRAGVRAETNKGHASPLPPSAAPTTDSTDSITGQNSRQREEELELID
  QLRKHIEYRLKVSLPCDLGAALTDGVVLCHLANHVRPRSVPSIHVPSPAVPKLTMAKCRR
  NVENFLEACRKIGVPQEQLCLPLHILEEKGLSQVAVTVQALLELAPPKQQQHQLSAV

• Sequence length: 777

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
LRCH3-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	35725478	Associate	★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	35871080	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for LRCH3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LRCH3.