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Gene Gene information from NCBI Gene database.
Entrez ID 79836
Gene name LON peptidase N-terminal domain and ring finger 3
Gene symbol LONRF3
Synonyms (NCBI Gene)
RNF127
Chromosome X
Chromosome location Xq24
Summary The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants hav
miRNA miRNA information provided by mirtarbase database.
308 Show/Hide all (308)
miRTarBase ID miRNA Experiments Reference
MIRT556435 hsa-miR-92a-3p HITS-CLIP 21572407
MIRT556434 hsa-miR-32-5p HITS-CLIP 21572407
MIRT556433 hsa-miR-363-3p HITS-CLIP 21572407
MIRT556432 hsa-miR-367-3p HITS-CLIP 21572407
MIRT556431 hsa-miR-92b-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
4
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20195357, 25416956, 32296183
GO:0005737 Component Cytoplasm IEA
GO:0008270 Function Zinc ion binding IEA
GO:0046872 Function Metal ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q496Y0
Protein name LON peptidase N-terminal domain and RING finger protein 3 (RING finger protein 127)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02190 LON_substr_bdg 555 → 752 ATP-dependent protease La (LON) substrate-binding domain Family
PF13923 zf-C3HC4_2 466 → 504 Domain
PF15227 zf-C3HC4_4 158 → 195 Domain
Sequence
MESVRIEQMLSLPAEVSSDNLESAERGASAAQVDMGPHPKVAAEGPAPLPTREPEQEQSP
GTSTPESKVLLTQADALASRGRIREALEVYRQLSERQQLVAEQLEQLVRCLAEKVPQGEA
LAPAPPDEGSTASGTVAAEETGAAAAAAATEVWDGFKCRKCHGFLSDPVSLSCGHTFCKL
CLERGRAADRRCALC
GVKLSALMVATGRARGARRAGQQPPPPLRVNVVLSGLLGKLFPGP
ARASQLRHEGNRLYRERQVEAALLKYNEAVKLAPNDHLLYSNRSQIYFTLESHENALHDA
EIACKLRPMGFKAHFRKAQALATLGKVEEALREFLYCVSLDGKNKRARCEAQRDNLELPH
CSSQEEAAARGDGSSLMDPAKVKGDGQQHHMKDQEEEEEKWDATSPKAASSKTGKCQEKK
RKHCQIESQEETGMPNKASKQDPPTDQGDKPALSLPLASFDASDLECALCMRLFYEPVTT
PCGHTFCLKCLERCLDHNAKCPLC
KDGLSQCLASRKYSKNVIMEELIAKFLPEELKERRK
LYEEEMEELSNLNKNVPIFVCTMAYPTVPCPLHIFEPCYRLMIRRCIETGTRQFGMCLGD
PVKGFAEYGCILEIRNVQFFADGRSVVDSIGKRRFRVLHQSQRDGYNTADIEYIEDQKVQ
GEDCAELMGLHNCVYQQASLWFHSLKLSLKNRILNHFGPMPEKDADPQMNPNGPAWCWWM
LAVLPLESRAQLPFLAMRSLKDRLNGIRRVLA
FISRNQN
Sequence length 759
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Hepatocellular carcinoma Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Malignant neoplasm of breast Breast Cancer UNIPROT_DG
★★★★★
★☆☆☆☆
Found in Text Mining only