LINC-PINT (long intergenic non-protein coding RNA, p53 induced transcript)

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Gene miRNA Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 378805
• Gene name: Long intergenic non-protein coding RNA, p53 induced transcript
• Gene symbol: LINC-PINT
• Synonyms (NCBI Gene): LincRNA-Pint, MKLN1-AS1, PINT, PINT87aa, TISPL
• Chromosome: 7
• Chromosome location: 7q32.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT737321	hsa-miR-21-3p	qRT-PCR	32401035

Other IDs

• MIM: 618212
• HGNC: 26885
• e!Ensembl: ENSG00000231721

Protein

• UniProt ID: A0A455ZAR2
• Protein name: Transcriptional regulator PINT87aa
• Protein function: Enhances the binding of the PAF1 complex to target gene promoters and plays a role in negative regulation of transcription (PubMed:30367041). May function as an anchor to keep the PAF1 complex on target gene promoters, sequentially pausing RNA p
• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, liver, kidney and stomach with lower levels in breast, intestine, thyroid and pancreas. {ECO:0000269|PubMed:30367041}.

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
LINC-PINT-related disorder	Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (34)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	30944652		★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	29703592		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	25751625, 29059683		★☆☆☆☆ Found in Text Mining only
Carcinoma of larynx	Laryngeal carcinoma	BEFREE	31131448		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	31711064		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	27708234		★☆☆☆☆ Found in Text Mining only
Clear-cell metastatic renal cell carcinoma	Renal Carcinoma	BEFREE	31417274		★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	27708234		★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	GWASCAT_DG	26237428		★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	31711064		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	31711064		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	31711064		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	31464068		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	31464068		★☆☆☆☆ Found in Text Mining only
Familial lichen amyloidosis	Lichen amyloidosis	BEFREE	27708234		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30367041		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30367041		★☆☆☆☆ Found in Text Mining only
High altitude pulmonary edema	High Altitude Pulmonary Edema	BEFREE	31761491		★☆☆☆☆ Found in Text Mining only
Jaundice, Obstructive	Jaundice	BEFREE	27708234		★☆☆☆☆ Found in Text Mining only
Malignant melanoma of skin of lower limb	Malignant melanoma of skin	GWASCAT_DG	26237428		★☆☆☆☆ Found in Text Mining only
Malignant melanoma of skin of upper limb	Malignant melanoma of skin	GWASCAT_DG	26237428		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	31464068		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of larynx	Larynx cancer	BEFREE	31131448		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	27708234		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29078818, 30944652, 31070482, 31131448, 31524232		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31452772		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27708234, 29078818, 30569513, 31010333, 31070482		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31010333		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	GWASCAT_DG	25086665, 29422604		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	27708234		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	30944652		★☆☆☆☆ Found in Text Mining only
Pervasive Development Disorder	Autism spectrum disorder	BEFREE	29703592		★☆☆☆☆ Found in Text Mining only
Retinal Diseases	Retinal Diseases	BEFREE	31711064		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	GWASCAT_DG	28604730		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for LINC-PINT.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LINC-PINT.