LHFPL4 (LHFPL tetraspan subfamily member 4)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 375323
• Gene name: LHFPL tetraspan subfamily member 4
• Gene symbol: LHFPL4
• Synonyms (NCBI Gene): GARLH4
• Chromosome: 3
• Chromosome location: 3p25.3
• Summary: This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-l

miRNA Show/Hide all (143)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020081	hsa-miR-361-5p	Sequencing	20371350
MIRT025599	hsa-miR-10a-5p	Sequencing	20371350
MIRT026228	hsa-miR-192-5p	Sequencing	20371350
MIRT1108784	hsa-miR-1184	CLIP-seq
MIRT1108785	hsa-miR-1197	CLIP-seq
MIRT1108786	hsa-miR-1205	CLIP-seq
MIRT1108787	hsa-miR-1207-5p	CLIP-seq
MIRT1108788	hsa-miR-1301	CLIP-seq
MIRT1108789	hsa-miR-149	CLIP-seq
MIRT1108790	hsa-miR-15a	CLIP-seq
MIRT1108791	hsa-miR-15b	CLIP-seq
MIRT1108792	hsa-miR-16	CLIP-seq
MIRT1108793	hsa-miR-1908	CLIP-seq
MIRT1108794	hsa-miR-1909	CLIP-seq
MIRT1108795	hsa-miR-1913	CLIP-seq
MIRT1108796	hsa-miR-195	CLIP-seq
MIRT1108797	hsa-miR-205	CLIP-seq
MIRT1108798	hsa-miR-2110	CLIP-seq
MIRT1108799	hsa-miR-214	CLIP-seq
MIRT1108800	hsa-miR-2277-3p	CLIP-seq
MIRT1108801	hsa-miR-298	CLIP-seq
MIRT1108802	hsa-miR-3131	CLIP-seq
MIRT1108803	hsa-miR-3154	CLIP-seq
MIRT1108804	hsa-miR-3155	CLIP-seq
MIRT1108805	hsa-miR-3155b	CLIP-seq
MIRT1108806	hsa-miR-3158-5p	CLIP-seq
MIRT1108807	hsa-miR-3179	CLIP-seq
MIRT1108808	hsa-miR-3183	CLIP-seq
MIRT1108809	hsa-miR-3189-3p	CLIP-seq
MIRT1108810	hsa-miR-3189-5p	CLIP-seq
MIRT1108811	hsa-miR-3195	CLIP-seq
MIRT1108812	hsa-miR-3202	CLIP-seq
MIRT1108813	hsa-miR-324-3p	CLIP-seq
MIRT1108814	hsa-miR-3619-5p	CLIP-seq
MIRT1108815	hsa-miR-3660	CLIP-seq
MIRT1108816	hsa-miR-3663-3p	CLIP-seq
MIRT1108817	hsa-miR-3665	CLIP-seq
MIRT1108818	hsa-miR-3936	CLIP-seq
MIRT1108819	hsa-miR-3939	CLIP-seq
MIRT1108820	hsa-miR-424	CLIP-seq
MIRT1108821	hsa-miR-4271	CLIP-seq
MIRT1108822	hsa-miR-4287	CLIP-seq
MIRT1108823	hsa-miR-4436a	CLIP-seq
MIRT1108824	hsa-miR-4448	CLIP-seq
MIRT1108825	hsa-miR-4455	CLIP-seq
MIRT1108826	hsa-miR-4481	CLIP-seq
MIRT1108827	hsa-miR-4514	CLIP-seq
MIRT1108828	hsa-miR-4526	CLIP-seq
MIRT1108829	hsa-miR-4527	CLIP-seq
MIRT1108830	hsa-miR-4530	CLIP-seq
MIRT1108831	hsa-miR-4645-5p	CLIP-seq
MIRT1108832	hsa-miR-4652-5p	CLIP-seq
MIRT1108833	hsa-miR-4660	CLIP-seq
MIRT1108834	hsa-miR-4673	CLIP-seq
MIRT1108835	hsa-miR-4685-3p	CLIP-seq
MIRT1108836	hsa-miR-4692	CLIP-seq
MIRT1108837	hsa-miR-4706	CLIP-seq
MIRT1108838	hsa-miR-4715-3p	CLIP-seq
MIRT1108839	hsa-miR-4718	CLIP-seq
MIRT1108840	hsa-miR-4722-3p	CLIP-seq
MIRT1108841	hsa-miR-4723-3p	CLIP-seq
MIRT1108842	hsa-miR-4725-3p	CLIP-seq
MIRT1108843	hsa-miR-4745-5p	CLIP-seq
MIRT1108844	hsa-miR-4747-5p	CLIP-seq
MIRT1108845	hsa-miR-4749-5p	CLIP-seq
MIRT1108846	hsa-miR-4758-3p	CLIP-seq
MIRT1108847	hsa-miR-4763-3p	CLIP-seq
MIRT1108848	hsa-miR-4793-5p	CLIP-seq
MIRT1108849	hsa-miR-484	CLIP-seq
MIRT1108850	hsa-miR-491-5p	CLIP-seq
MIRT1108851	hsa-miR-497	CLIP-seq
MIRT1108852	hsa-miR-5047	CLIP-seq
MIRT1108853	hsa-miR-524-3p	CLIP-seq
MIRT1108854	hsa-miR-525-3p	CLIP-seq
MIRT1108855	hsa-miR-541	CLIP-seq
MIRT1108856	hsa-miR-603	CLIP-seq
MIRT1108857	hsa-miR-609	CLIP-seq
MIRT1108858	hsa-miR-611	CLIP-seq
MIRT1108859	hsa-miR-654-5p	CLIP-seq
MIRT1108860	hsa-miR-657	CLIP-seq
MIRT1108861	hsa-miR-663	CLIP-seq
MIRT1108862	hsa-miR-670	CLIP-seq
MIRT1108863	hsa-miR-761	CLIP-seq
MIRT1108864	hsa-miR-922	CLIP-seq
MIRT1108865	hsa-miR-939	CLIP-seq
MIRT1108866	hsa-miR-940	CLIP-seq
MIRT1108784	hsa-miR-1184	CLIP-seq
MIRT1108786	hsa-miR-1205	CLIP-seq
MIRT1108787	hsa-miR-1207-5p	CLIP-seq
MIRT2030097	hsa-miR-1285	CLIP-seq
MIRT1108794	hsa-miR-1909	CLIP-seq
MIRT1108801	hsa-miR-298	CLIP-seq
MIRT2030098	hsa-miR-3157-5p	CLIP-seq
MIRT1108806	hsa-miR-3158-5p	CLIP-seq
MIRT2030099	hsa-miR-3187-5p	CLIP-seq
MIRT2030100	hsa-miR-345	CLIP-seq
MIRT2030101	hsa-miR-378g	CLIP-seq
MIRT2030102	hsa-miR-3918	CLIP-seq
MIRT2030103	hsa-miR-4286	CLIP-seq
MIRT2030104	hsa-miR-4292	CLIP-seq
MIRT1108831	hsa-miR-4645-5p	CLIP-seq
MIRT1108834	hsa-miR-4673	CLIP-seq
MIRT1108847	hsa-miR-4763-3p	CLIP-seq
MIRT2030105	hsa-miR-4771	CLIP-seq
MIRT2030106	hsa-miR-612	CLIP-seq
MIRT2030107	hsa-miR-615-5p	CLIP-seq
MIRT2030108	hsa-miR-873	CLIP-seq
MIRT1108866	hsa-miR-940	CLIP-seq
MIRT1108787	hsa-miR-1207-5p	CLIP-seq
MIRT1108801	hsa-miR-298	CLIP-seq
MIRT1108803	hsa-miR-3154	CLIP-seq
MIRT1108804	hsa-miR-3155	CLIP-seq
MIRT1108805	hsa-miR-3155b	CLIP-seq
MIRT1108807	hsa-miR-3179	CLIP-seq
MIRT1108818	hsa-miR-3936	CLIP-seq
MIRT1108819	hsa-miR-3939	CLIP-seq
MIRT2261005	hsa-miR-4265	CLIP-seq
MIRT2030103	hsa-miR-4286	CLIP-seq
MIRT1108822	hsa-miR-4287	CLIP-seq
MIRT2261006	hsa-miR-4296	CLIP-seq
MIRT2261007	hsa-miR-4318	CLIP-seq
MIRT2261008	hsa-miR-4322	CLIP-seq
MIRT2261009	hsa-miR-4417	CLIP-seq
MIRT1108823	hsa-miR-4436a	CLIP-seq
MIRT2261010	hsa-miR-4640-5p	CLIP-seq
MIRT1108835	hsa-miR-4685-3p	CLIP-seq
MIRT2261011	hsa-miR-4726-5p	CLIP-seq
MIRT2261012	hsa-miR-4753-3p	CLIP-seq
MIRT1108847	hsa-miR-4763-3p	CLIP-seq
MIRT1108849	hsa-miR-484	CLIP-seq
MIRT2261013	hsa-miR-942	CLIP-seq
MIRT2390124	hsa-miR-122	CLIP-seq
MIRT2390125	hsa-miR-3616-3p	CLIP-seq
MIRT2030102	hsa-miR-3918	CLIP-seq
MIRT2390126	hsa-miR-4436b-3p	CLIP-seq
MIRT2390127	hsa-miR-4790-3p	CLIP-seq
MIRT2453009	hsa-miR-3922-5p	CLIP-seq
MIRT2453010	hsa-miR-4290	CLIP-seq
MIRT2453011	hsa-miR-4469	CLIP-seq
MIRT2453012	hsa-miR-4667-3p	CLIP-seq
MIRT2453009	hsa-miR-3922-5p	CLIP-seq
MIRT2453010	hsa-miR-4290	CLIP-seq
MIRT2453012	hsa-miR-4667-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28978485, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007605	Process	Sensory perception of sound	IBA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0042995	Component	Cell projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IBA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:0050811	Function	GABA receptor binding	IBA
GO:0050811	Function	GABA receptor binding	IEA
GO:0060077	Component	Inhibitory synapse	IBA
GO:0060077	Component	Inhibitory synapse	IEA
GO:0060077	Component	Inhibitory synapse	ISS
GO:0097112	Process	Gamma-aminobutyric acid receptor clustering	IBA
GO:0097112	Process	Gamma-aminobutyric acid receptor clustering	IEA
GO:0097112	Process	Gamma-aminobutyric acid receptor clustering	ISS
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099572	Component	Postsynaptic specialization	IEA
GO:0099645	Process	Neurotransmitter receptor localization to postsynaptic specialization membrane	IEA
GO:1905702	Process	Regulation of inhibitory synapse assembly	IEA
GO:1905702	Process	Regulation of inhibitory synapse assembly	ISS

Other IDs

• MIM: 610240
• HGNC: 29568
• e!Ensembl: ENSG00000156959

Protein

• UniProt ID: Q7Z7J7
• Protein name: LHFPL tetraspan subfamily member 4 protein (GABAA receptor regulatory Lhfpl4) (Lipoma HMGIC fusion partner-like 4 protein)
• Protein function: Plays a role in the regulation of inhibitory synapse formation and function by being involved in maintening gamma-aminobutyric acid receptors (GABAARs) clustering and their associated scaffold proteins at inhibitory synaptic sites. Acts in conce
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10242	L_HMGIC_fpl	22 → 200	Lipoma HMGIC fusion partner-like protein	Family

• Sequence:

  MLPSQEASKLYHEHYMRNSRAIGVLWAIFTICFAIINVVVFIQPYWVGDSVSTPKPGYFG
  LFHYCVGSGLAGRELTCRGSFTDFSTIPSSAFKAAAFFVLLSMVLILGCITCFSLFFFCN
  TATVYKICAWMQLLAALCLVLGCMIFPDGWDAETIRDMCGAKTGKYSLGDCSVRWAYILA
  IIGILNALILSFLAFVLGNRQTDLLQEELKPENKDFVGSTVSSVLRPGGDVSGWGVLPCP
  VAHSQGP

• Sequence length: 247

Related Genes

No strongly related genes found yet for LHFPL4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LHFPL4.