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Gene Gene information from NCBI Gene database.
Entrez ID 3964
Gene name Galectin 8
Gene symbol LGALS8
Synonyms (NCBI Gene)
Gal-8PCTA-1PCTA1Po66-CBP
Chromosome 1
Chromosome location 1q43
Summary This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation
miRNA miRNA information provided by mirtarbase database.
861 Show/Hide all (861)
miRTarBase ID miRNA Experiments Reference
MIRT630546 hsa-miR-5700 HITS-CLIP 19536157
MIRT630545 hsa-miR-877-3p HITS-CLIP 19536157
MIRT630544 hsa-miR-3140-5p HITS-CLIP 19536157
MIRT630543 hsa-miR-1236-3p HITS-CLIP 19536157
MIRT630542 hsa-miR-2682-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20 Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0002317 Process Plasma cell differentiation IEA
GO:0005178 Function Integrin binding IPI 19268462
GO:0005515 Function Protein binding IPI 16189514, 18511908, 19268462, 22246324, 25416956, 28514442, 29892012, 31515488, 32296183, 32814053, 32915505, 33961781
GO:0005615 Component Extracellular space TAS 8692978
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606099 6569 ENSG00000116977
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00214
Protein name Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Protein function Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by b
PDB 2YRO , 2YV8 , 2YXS , 3AP4 , 3AP5 , 3AP6 , 3AP7 , 3AP9 , 3APB , 3OJB , 3VKL , 3VKM , 3VKN , 3VKO , 4BMB , 4BME , 4FQZ , 4GXL , 4HAN , 5GZC , 5GZD , 5GZE , 5GZF , 5GZG , 5T7I , 5T7S , 5T7T , 5T7U , 5VWG , 6W4Z , 6Z6Y , 7AEN , 7ALS , 7P1M , 8CM8 , 8HL9 , 9FYJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 18 → 151 Galactoside-binding lectin Domain
PF00337 Gal-bind_lectin 186 → 316 Galactoside-binding lectin Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy.
Sequence
Sequence length 317
Interactions View interactions