LEFTY1 (left-right determination factor 1)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10637
• Gene name: Left-right determination factor 1
• Gene symbol: LEFTY1
• Synonyms (NCBI Gene): LEFTB, LEFTYB
• Chromosome: 1
• Chromosome location: 1q42.12
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate

miRNA Show/Hide all (147)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005556	hsa-miR-302a-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blot	21266536
MIRT005633	hsa-miR-302d-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, Northern blot, qRT-PCR, Western blo	21266536
MIRT053304	hsa-miR-372-3p	Luciferase reporter assay, qRT-PCR, Western blot	22020335
MIRT053305	hsa-miR-373-3p	Luciferase reporter assay, qRT-PCR, Western blot	22020335
MIRT053305	hsa-miR-373-3p	Luciferase reporter assay	24709321
MIRT053305	hsa-miR-373-3p	Luciferase reporter assay	24709321
MIRT536388	hsa-miR-548p	PAR-CLIP	22012620
MIRT536387	hsa-miR-4324	PAR-CLIP	22012620
MIRT536386	hsa-miR-544b	PAR-CLIP	22012620
MIRT536385	hsa-miR-4251	PAR-CLIP	22012620
MIRT536384	hsa-miR-1253	PAR-CLIP	22012620
MIRT536383	hsa-miR-6770-5p	PAR-CLIP	22012620
MIRT536382	hsa-let-7a-5p	PAR-CLIP	22012620
MIRT536381	hsa-let-7b-5p	PAR-CLIP	22012620
MIRT536380	hsa-let-7c-5p	PAR-CLIP	22012620
MIRT536379	hsa-let-7d-5p	PAR-CLIP	22012620
MIRT536378	hsa-let-7e-5p	PAR-CLIP	22012620
MIRT536377	hsa-let-7f-5p	PAR-CLIP	22012620
MIRT536376	hsa-let-7g-5p	PAR-CLIP	22012620
MIRT536375	hsa-let-7i-5p	PAR-CLIP	22012620
MIRT536374	hsa-miR-4458	PAR-CLIP	22012620
MIRT536373	hsa-miR-4500	PAR-CLIP	22012620
MIRT536372	hsa-miR-98-5p	PAR-CLIP	22012620
MIRT536371	hsa-miR-202-3p	PAR-CLIP	22012620
MIRT536370	hsa-miR-4710	PAR-CLIP	22012620
MIRT536369	hsa-miR-1294	PAR-CLIP	22012620
MIRT536368	hsa-miR-6800-5p	PAR-CLIP	22012620
MIRT536366	hsa-miR-6802-5p	PAR-CLIP	22012620
MIRT536367	hsa-miR-378a-5p	PAR-CLIP	22012620
MIRT536365	hsa-miR-1200	PAR-CLIP	22012620
MIRT536358	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536364	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT053304	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536363	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536362	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536361	hsa-miR-520b	PAR-CLIP	22012620
MIRT053305	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536360	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536359	hsa-miR-302e	PAR-CLIP	22012620
MIRT005633	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536358	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT005556	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536357	hsa-miR-520e	PAR-CLIP	22012620
MIRT536356	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536355	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT536354	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT536353	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT536352	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT536351	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT536350	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT536349	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT536348	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT536347	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536332	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT536346	hsa-miR-144-3p	PAR-CLIP	22012620
MIRT536345	hsa-miR-3925-5p	PAR-CLIP	22012620
MIRT536344	hsa-miR-3123	PAR-CLIP	22012620
MIRT536343	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT536342	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT536341	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT536340	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT536339	hsa-miR-3666	PAR-CLIP	22012620
MIRT536338	hsa-miR-4295	PAR-CLIP	22012620
MIRT536337	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT536336	hsa-miR-3976	PAR-CLIP	22012620
MIRT536335	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT536334	hsa-miR-4290	PAR-CLIP	22012620
MIRT536333	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536332	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT536331	hsa-miR-582-5p	PAR-CLIP	22012620
MIRT536330	hsa-miR-4671-3p	PAR-CLIP	22012620
MIRT536388	hsa-miR-548p	PAR-CLIP	22012620
MIRT536387	hsa-miR-4324	PAR-CLIP	22012620
MIRT536386	hsa-miR-544b	PAR-CLIP	22012620
MIRT536385	hsa-miR-4251	PAR-CLIP	22012620
MIRT536384	hsa-miR-1253	PAR-CLIP	22012620
MIRT536383	hsa-miR-6770-5p	PAR-CLIP	22012620
MIRT536382	hsa-let-7a-5p	PAR-CLIP	22012620
MIRT536381	hsa-let-7b-5p	PAR-CLIP	22012620
MIRT536380	hsa-let-7c-5p	PAR-CLIP	22012620
MIRT536379	hsa-let-7d-5p	PAR-CLIP	22012620
MIRT536378	hsa-let-7e-5p	PAR-CLIP	22012620
MIRT536377	hsa-let-7f-5p	PAR-CLIP	22012620
MIRT536376	hsa-let-7g-5p	PAR-CLIP	22012620
MIRT536375	hsa-let-7i-5p	PAR-CLIP	22012620
MIRT536374	hsa-miR-4458	PAR-CLIP	22012620
MIRT536373	hsa-miR-4500	PAR-CLIP	22012620
MIRT536372	hsa-miR-98-5p	PAR-CLIP	22012620
MIRT536371	hsa-miR-202-3p	PAR-CLIP	22012620
MIRT536370	hsa-miR-4710	PAR-CLIP	22012620
MIRT536369	hsa-miR-1294	PAR-CLIP	22012620
MIRT536368	hsa-miR-6800-5p	PAR-CLIP	22012620
MIRT536366	hsa-miR-6802-5p	PAR-CLIP	22012620
MIRT536367	hsa-miR-378a-5p	PAR-CLIP	22012620
MIRT536365	hsa-miR-1200	PAR-CLIP	22012620
MIRT536358	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT536364	hsa-miR-520f-3p	PAR-CLIP	22012620
MIRT053304	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT536363	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT536362	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT536361	hsa-miR-520b	PAR-CLIP	22012620
MIRT053305	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT536360	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT536359	hsa-miR-302e	PAR-CLIP	22012620
MIRT005633	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT536358	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT005556	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT536357	hsa-miR-520e	PAR-CLIP	22012620
MIRT536356	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT536355	hsa-miR-548a-3p	PAR-CLIP	22012620
MIRT536354	hsa-miR-548ar-3p	PAR-CLIP	22012620
MIRT536353	hsa-miR-548az-3p	PAR-CLIP	22012620
MIRT536352	hsa-miR-548e-3p	PAR-CLIP	22012620
MIRT536351	hsa-miR-548f-3p	PAR-CLIP	22012620
MIRT536350	hsa-miR-6507-5p	PAR-CLIP	22012620
MIRT536349	hsa-miR-519a-3p	PAR-CLIP	22012620
MIRT536348	hsa-miR-519b-3p	PAR-CLIP	22012620
MIRT536347	hsa-miR-519c-3p	PAR-CLIP	22012620
MIRT536332	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT536346	hsa-miR-144-3p	PAR-CLIP	22012620
MIRT536345	hsa-miR-3925-5p	PAR-CLIP	22012620
MIRT536344	hsa-miR-3123	PAR-CLIP	22012620
MIRT536343	hsa-miR-130a-3p	PAR-CLIP	22012620
MIRT536342	hsa-miR-130b-3p	PAR-CLIP	22012620
MIRT536341	hsa-miR-301a-3p	PAR-CLIP	22012620
MIRT536340	hsa-miR-301b-3p	PAR-CLIP	22012620
MIRT536339	hsa-miR-3666	PAR-CLIP	22012620
MIRT536338	hsa-miR-4295	PAR-CLIP	22012620
MIRT536337	hsa-miR-454-3p	PAR-CLIP	22012620
MIRT536336	hsa-miR-3976	PAR-CLIP	22012620
MIRT536335	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT536334	hsa-miR-4290	PAR-CLIP	22012620
MIRT536333	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT536332	hsa-miR-101-3p	PAR-CLIP	22012620
MIRT536331	hsa-miR-582-5p	PAR-CLIP	22012620
MIRT536330	hsa-miR-4671-3p	PAR-CLIP	22012620
MIRT1107225	hsa-miR-3125	CLIP-seq
MIRT1107226	hsa-miR-3916	CLIP-seq
MIRT1107227	hsa-miR-4257	CLIP-seq
MIRT1107228	hsa-miR-4307	CLIP-seq
MIRT1107229	hsa-miR-4731-3p	CLIP-seq
MIRT1107230	hsa-miR-4801	CLIP-seq
MIRT1107231	hsa-miR-520d-5p	CLIP-seq
MIRT1107232	hsa-miR-524-5p	CLIP-seq
MIRT1107233	hsa-miR-548e	CLIP-seq
MIRT1107234	hsa-miR-548f	CLIP-seq
MIRT1107235	hsa-miR-664	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU5F1	Activation	17068183

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0003007	Process	Heart morphogenesis	ISS
GO:0005125	Function	Cytokine activity	IBA
GO:0005125	Function	Cytokine activity	IEA
GO:0005160	Function	Transforming growth factor beta receptor binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	TAS	10053005
GO:0007368	Process	Determination of left/right symmetry	ISS
GO:0008083	Function	Growth factor activity	IEA
GO:0009948	Process	Anterior/posterior axis specification	IBA
GO:0030509	Process	BMP signaling pathway	IBA

Other IDs

• MIM: 603037
• HGNC: 6552
• e!Ensembl: ENSG00000243709

Protein

• UniProt ID: O75610
• Protein name: Left-right determination factor 1 (Left-right determination factor B) (Protein lefty-1) (Protein lefty-B)
• Protein function: Required for left-right axis determination as a regulator of LEFTY2 and NODAL.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00019	TGF_beta	262 → 353	Transforming growth factor beta like domain	Domain
  PF00688	TGFb_propeptide	25 → 228	TGF-beta propeptide	Family

• Sequence:

  MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLDRADMEELVIPTHVRAQ
  YVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLVFGMEQRLPPNSELVQAVLRL
  FQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDV
  TEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTL
  DLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCRQP
  PEALAFKWPFLGPRQCIASETDSLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALV
  PRRLQP

• Sequence length: 366

Pathways

KEGG Pathway

TGF-beta signaling pathway

Signaling pathways regulating pluripotency of stem cells

Related Genes

Sort by: Blended Diseases Pathways Evidence source

ID3 2 shared pathwaysTGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells Related via 2 shared pathways including TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells. ID4 2 shared pathwaysTGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells Related via 2 shared pathways including TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells. NODAL 2 shared pathwaysTGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells Related via 2 shared pathways including TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells. SKIL 2 shared pathwaysTGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells Related via 2 shared pathways including TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells. LEFTY2 2 shared pathwaysTGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells Related via 2 shared pathways including TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
ID3	0	[]	2	["TGF-beta signaling pathway","Signaling pathways regulating pluripotency of stem cells"]	0	[]
ID4	0	[]	2	["TGF-beta signaling pathway","Signaling pathways regulating pluripotency of stem cells"]	0	[]
NODAL	0	[]	2	["TGF-beta signaling pathway","Signaling pathways regulating pluripotency of stem cells"]	0	[]
SKIL	0	[]	2	["TGF-beta signaling pathway","Signaling pathways regulating pluripotency of stem cells"]	0	[]
LEFTY2	0	[]	2	["TGF-beta signaling pathway","Signaling pathways regulating pluripotency of stem cells"]	0	[]

Diseases Linked via Similar Genes

Carcinoma Linked via 2 of 5 related genesID3, ID4 Heterotaxy syndrome Linked via 2 of 5 related genesNODAL, LEFTY2 Tetralogy of fallot Linked via 2 of 5 related genesNODAL, LEFTY2 Burkitt lymphoma Linked via 1 of 5 related genesID3 Colonic neoplasms Linked via 1 of 5 related genesID3

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Carcinoma	2	["ID3","ID4"]
Heterotaxy syndrome	2	["NODAL","LEFTY2"]
Tetralogy of fallot	2	["NODAL","LEFTY2"]
Burkitt lymphoma	1	["ID3"]
Colonic neoplasms	1	["ID3"]