LEAP2 (liver enriched antimicrobial peptide 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 116842
• Gene name: Liver enriched antimicrobial peptide 2
• Gene symbol: LEAP2
• Synonyms (NCBI Gene): LEAP-2
• Chromosome: 5
• Chromosome location: 5q31.1
• Summary: This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]

miRNA Show/Hide all (103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024622	hsa-miR-215-5p	Microarray	19074876
MIRT026180	hsa-miR-192-5p	Microarray	19074876
MIRT675443	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT675442	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT675441	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT675440	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT675439	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT518257	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT675438	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT675437	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT675436	hsa-miR-3672	HITS-CLIP	23824327
MIRT675435	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT675434	hsa-miR-8055	HITS-CLIP	23824327
MIRT675433	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT648459	hsa-miR-100-3p	HITS-CLIP	23824327
MIRT648458	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT648457	hsa-miR-8062	HITS-CLIP	23824327
MIRT648456	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT648455	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT648454	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT648453	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT648452	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT648451	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT648450	hsa-miR-1976	HITS-CLIP	23824327
MIRT648449	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT648448	hsa-miR-4279	HITS-CLIP	23824327
MIRT648447	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT648446	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT518270	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT518269	hsa-miR-5693	PAR-CLIP	23446348
MIRT518268	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT518267	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT518266	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT518265	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT518264	hsa-miR-4505	PAR-CLIP	23446348
MIRT518263	hsa-miR-5787	PAR-CLIP	23446348
MIRT518262	hsa-miR-342-5p	PAR-CLIP	23446348
MIRT518261	hsa-miR-4664-5p	PAR-CLIP	23446348
MIRT518260	hsa-miR-4651	PAR-CLIP	23446348
MIRT518259	hsa-miR-608	PAR-CLIP	23446348
MIRT518258	hsa-miR-6747-5p	PAR-CLIP	23446348
MIRT518257	hsa-miR-6879-3p	PAR-CLIP	23446348
MIRT518256	hsa-miR-143-5p	PAR-CLIP	23446348
MIRT518255	hsa-miR-6737-5p	PAR-CLIP	23446348
MIRT518254	hsa-miR-6812-5p	PAR-CLIP	23446348
MIRT518253	hsa-miR-6819-5p	PAR-CLIP	23446348
MIRT518252	hsa-miR-6776-5p	PAR-CLIP	23446348
MIRT675443	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT675442	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT675441	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT675440	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT675439	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT518257	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT675438	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT675437	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT675436	hsa-miR-3672	HITS-CLIP	23824327
MIRT675435	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT675434	hsa-miR-8055	HITS-CLIP	23824327
MIRT675433	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT648459	hsa-miR-100-3p	HITS-CLIP	23824327
MIRT648458	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT648457	hsa-miR-8062	HITS-CLIP	23824327
MIRT648456	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT648455	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT648454	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT648453	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT648452	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT648451	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT648450	hsa-miR-1976	HITS-CLIP	23824327
MIRT648449	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT648448	hsa-miR-4279	HITS-CLIP	23824327
MIRT648447	hsa-miR-514a-3p	HITS-CLIP	23824327
MIRT648446	hsa-miR-514b-3p	HITS-CLIP	23824327
MIRT518270	hsa-miR-500b-3p	PAR-CLIP	23446348
MIRT518269	hsa-miR-5693	PAR-CLIP	23446348
MIRT518268	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT518267	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT518266	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT518265	hsa-miR-3622b-5p	PAR-CLIP	23446348
MIRT518264	hsa-miR-4505	PAR-CLIP	23446348
MIRT518263	hsa-miR-5787	PAR-CLIP	23446348
MIRT518262	hsa-miR-342-5p	PAR-CLIP	23446348
MIRT518261	hsa-miR-4664-5p	PAR-CLIP	23446348
MIRT518260	hsa-miR-4651	PAR-CLIP	23446348
MIRT518259	hsa-miR-608	PAR-CLIP	23446348
MIRT518258	hsa-miR-6747-5p	PAR-CLIP	23446348
MIRT518257	hsa-miR-6879-3p	PAR-CLIP	23446348
MIRT518256	hsa-miR-143-5p	PAR-CLIP	23446348
MIRT518255	hsa-miR-6737-5p	PAR-CLIP	23446348
MIRT518254	hsa-miR-6812-5p	PAR-CLIP	23446348
MIRT518253	hsa-miR-6819-5p	PAR-CLIP	23446348
MIRT518252	hsa-miR-6776-5p	PAR-CLIP	23446348
MIRT2029632	hsa-miR-1237	CLIP-seq
MIRT2029633	hsa-miR-1248	CLIP-seq
MIRT2029634	hsa-miR-3124-3p	CLIP-seq
MIRT2029635	hsa-miR-3646	CLIP-seq
MIRT2029636	hsa-miR-3662	CLIP-seq
MIRT2029637	hsa-miR-371b-5p	CLIP-seq
MIRT2029638	hsa-miR-4446-5p	CLIP-seq
MIRT2029639	hsa-miR-4698	CLIP-seq
MIRT2029640	hsa-miR-4755-5p	CLIP-seq
MIRT2029641	hsa-miR-500a	CLIP-seq
MIRT2029642	hsa-miR-642a	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0042742	Process	Defense response to bacterium	IEA
GO:0050832	Process	Defense response to fungus	IMP	12493837
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IMP	12493837

Other IDs

• MIM: 611373
• HGNC: 29571
• e!Ensembl: ENSG00000164406

Protein

• UniProt ID: Q969E1
• Protein name: Liver-expressed antimicrobial peptide 2 (LEAP-2)
• Protein function: Has an antimicrobial activity.
• PDB: 2L1Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07359	LEAP-2	1 → 77	Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)	Family

• Sequence:

  MWHLKLCAVLMIFLLLLGQIDGSPIPEVSSAKRRPRRMTPFWRGVSLRPIGASCRDDSEC
  ITRLCRKRRCSLSVAQE

• Sequence length: 77

Pathways

Reactome Pathway:

Antimicrobial peptides

Related Genes

No strongly related genes found yet for LEAP2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LEAP2.