LCE1A (late cornified envelope 1A)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 353131
• Gene name: Late cornified envelope 1A
• Gene symbol: LCE1A
• Synonyms (NCBI Gene): LEP1
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relat

miRNA Show/Hide all (68)

miRTarBase ID	miRNA	Experiments	Reference
MIRT718241	hsa-miR-4436b-3p	HITS-CLIP	19536157
MIRT718240	hsa-miR-4632-5p	HITS-CLIP	19536157
MIRT718239	hsa-miR-6735-5p	HITS-CLIP	19536157
MIRT718238	hsa-miR-6879-5p	HITS-CLIP	19536157
MIRT718237	hsa-miR-7843-5p	HITS-CLIP	19536157
MIRT718236	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT718235	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT718234	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT718233	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT718232	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT718231	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT718230	hsa-miR-378j	HITS-CLIP	19536157
MIRT718229	hsa-miR-6839-5p	HITS-CLIP	19536157
MIRT718228	hsa-miR-1299	HITS-CLIP	19536157
MIRT718227	hsa-miR-516b-5p	HITS-CLIP	19536157
MIRT718226	hsa-miR-4782-5p	HITS-CLIP	19536157
MIRT718225	hsa-miR-5706	HITS-CLIP	19536157
MIRT457942	hsa-miR-33a-3p	PAR-CLIP	23592263
MIRT457941	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT457940	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT457939	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT457938	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT457937	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT457936	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT457935	hsa-miR-4784	PAR-CLIP	23592263
MIRT457934	hsa-miR-5093	PAR-CLIP	23592263
MIRT457933	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT457932	hsa-miR-4710	PAR-CLIP	23592263
MIRT457930	hsa-miR-4689	PAR-CLIP	23592263
MIRT457931	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT718241	hsa-miR-4436b-3p	HITS-CLIP	19536157
MIRT718240	hsa-miR-4632-5p	HITS-CLIP	19536157
MIRT718239	hsa-miR-6735-5p	HITS-CLIP	19536157
MIRT718238	hsa-miR-6879-5p	HITS-CLIP	19536157
MIRT718237	hsa-miR-7843-5p	HITS-CLIP	19536157
MIRT718236	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT718235	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT718234	hsa-miR-6840-3p	HITS-CLIP	19536157
MIRT718233	hsa-miR-1915-3p	HITS-CLIP	19536157
MIRT718232	hsa-miR-6764-5p	HITS-CLIP	19536157
MIRT718231	hsa-miR-4726-3p	HITS-CLIP	19536157
MIRT718230	hsa-miR-378j	HITS-CLIP	19536157
MIRT718229	hsa-miR-6839-5p	HITS-CLIP	19536157
MIRT718228	hsa-miR-1299	HITS-CLIP	19536157
MIRT718227	hsa-miR-516b-5p	HITS-CLIP	19536157
MIRT718226	hsa-miR-4782-5p	HITS-CLIP	19536157
MIRT718225	hsa-miR-5706	HITS-CLIP	19536157
MIRT457942	hsa-miR-33a-3p	PAR-CLIP	23592263
MIRT457941	hsa-miR-552-3p	PAR-CLIP	23592263
MIRT457940	hsa-miR-4524b-3p	PAR-CLIP	23592263
MIRT457939	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT457938	hsa-miR-203a-3p	PAR-CLIP	23592263
MIRT457937	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT457936	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT457935	hsa-miR-4784	PAR-CLIP	23592263
MIRT457934	hsa-miR-5093	PAR-CLIP	23592263
MIRT457933	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT457932	hsa-miR-4710	PAR-CLIP	23592263
MIRT457930	hsa-miR-4689	PAR-CLIP	23592263
MIRT457931	hsa-miR-6858-5p	PAR-CLIP	23592263
MIRT1105540	hsa-miR-4459	CLIP-seq
MIRT1105541	hsa-miR-552	CLIP-seq
MIRT1105542	hsa-miR-665	CLIP-seq
MIRT1105543	hsa-miR-765	CLIP-seq
MIRT2029090	hsa-miR-450b-3p	CLIP-seq
MIRT2029091	hsa-miR-4713-3p	CLIP-seq
MIRT2029092	hsa-miR-638	CLIP-seq
MIRT2029093	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005829	Component	Cytosol	TAS
GO:0008544	Process	Epidermis development	IEA
GO:0031424	Process	Keratinization	IEA

Other IDs

• MIM: 612603
• HGNC: 29459
• e!Ensembl: ENSG00000186844

Protein

• UniProt ID: Q5T7P2
• Protein name: Late cornified envelope protein 1A (Late envelope protein 1)
• Protein function: Precursors of the cornified envelope of the stratum corneum.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14672	LCE	27 → 110	Late cornified envelope	Family

• Tissue specificity: TISSUE SPECIFICITY: Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. {ECO:0000269|PubMed:15854049}.
• Sequence:

  MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCCSVSSGGCCGSSSGGGC
  SSGGGGCCLSHHRRHRSHRHRLQSSGCCSQPSGGSSCCGGDSGQHSGGCC

• Sequence length: 110

Pathways

Reactome Pathway:

Formation of the cornified envelope

Related Genes

No strongly related genes found yet for LCE1A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LCE1A.