LARP6 (La ribonucleoprotein 6, translational regulator)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55323
• Gene name: La ribonucleoprotein 6, translational regulator
• Gene symbol: LARP6
• Synonyms (NCBI Gene): ACHN
• Chromosome: 15
• Chromosome location: 15q23

miRNA Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037593	hsa-miR-744-5p	CLASH	23622248
MIRT732568	hsa-miR-129-2-3p	Microarray	33514440
MIRT1104848	hsa-miR-3157-5p	CLIP-seq
MIRT1104849	hsa-miR-342-3p	CLIP-seq
MIRT1104850	hsa-miR-377	CLIP-seq
MIRT1104851	hsa-miR-4691-3p	CLIP-seq
MIRT1104852	hsa-miR-1206	CLIP-seq
MIRT1104853	hsa-miR-204	CLIP-seq
MIRT1104854	hsa-miR-211	CLIP-seq
MIRT1104855	hsa-miR-331-5p	CLIP-seq
MIRT1104856	hsa-miR-410	CLIP-seq
MIRT1104857	hsa-miR-4652-3p	CLIP-seq
MIRT1104858	hsa-miR-4678	CLIP-seq
MIRT1104859	hsa-miR-4729	CLIP-seq
MIRT1104860	hsa-miR-4755-5p	CLIP-seq
MIRT1104861	hsa-miR-4778-5p	CLIP-seq
MIRT1104862	hsa-miR-548u	CLIP-seq
MIRT1104863	hsa-miR-579	CLIP-seq
MIRT1104864	hsa-miR-623	CLIP-seq
MIRT1556611	hsa-miR-3924	CLIP-seq
MIRT1556612	hsa-miR-577	CLIP-seq
MIRT1556613	hsa-miR-656	CLIP-seq
MIRT2560195	hsa-miR-126	CLIP-seq
MIRT2560196	hsa-miR-1289	CLIP-seq
MIRT2560197	hsa-miR-3140-5p	CLIP-seq
MIRT2560198	hsa-miR-3154	CLIP-seq
MIRT1104848	hsa-miR-3157-5p	CLIP-seq
MIRT2560199	hsa-miR-3187-3p	CLIP-seq
MIRT2560200	hsa-miR-323-5p	CLIP-seq
MIRT2560201	hsa-miR-3677-5p	CLIP-seq
MIRT1104850	hsa-miR-377	CLIP-seq
MIRT1556611	hsa-miR-3924	CLIP-seq
MIRT2560202	hsa-miR-4433	CLIP-seq
MIRT2560203	hsa-miR-4529-5p	CLIP-seq
MIRT2560204	hsa-miR-4539	CLIP-seq
MIRT2560205	hsa-miR-4646-5p	CLIP-seq
MIRT1104851	hsa-miR-4691-3p	CLIP-seq
MIRT2560206	hsa-miR-4698	CLIP-seq
MIRT2560207	hsa-miR-4731-5p	CLIP-seq
MIRT2560208	hsa-miR-4747-5p	CLIP-seq
MIRT2560209	hsa-miR-4773	CLIP-seq
MIRT1556612	hsa-miR-577	CLIP-seq
MIRT1556613	hsa-miR-656	CLIP-seq
MIRT2560195	hsa-miR-126	CLIP-seq
MIRT2560196	hsa-miR-1289	CLIP-seq
MIRT2560197	hsa-miR-3140-5p	CLIP-seq
MIRT2560198	hsa-miR-3154	CLIP-seq
MIRT1104848	hsa-miR-3157-5p	CLIP-seq
MIRT2560199	hsa-miR-3187-3p	CLIP-seq
MIRT2560200	hsa-miR-323-5p	CLIP-seq
MIRT2560201	hsa-miR-3677-5p	CLIP-seq
MIRT1104850	hsa-miR-377	CLIP-seq
MIRT1556611	hsa-miR-3924	CLIP-seq
MIRT2560202	hsa-miR-4433	CLIP-seq
MIRT2560203	hsa-miR-4529-5p	CLIP-seq
MIRT2560204	hsa-miR-4539	CLIP-seq
MIRT2560205	hsa-miR-4646-5p	CLIP-seq
MIRT1104851	hsa-miR-4691-3p	CLIP-seq
MIRT2560206	hsa-miR-4698	CLIP-seq
MIRT2560207	hsa-miR-4731-5p	CLIP-seq
MIRT2560208	hsa-miR-4747-5p	CLIP-seq
MIRT2560209	hsa-miR-4773	CLIP-seq
MIRT1556612	hsa-miR-577	CLIP-seq
MIRT1556613	hsa-miR-656	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	20603131, 21746880, 22190748
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	21746880
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	20603131, 22190748
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IMP	21746880
GO:0006396	Process	RNA processing	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0017022	Function	Myosin binding	IPI	20603131
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IMP	21746880
GO:0035613	Function	RNA stem-loop binding	IDA	20603131
GO:0035613	Function	RNA stem-loop binding	IMP	21746880
GO:0048027	Function	MRNA 5'-UTR binding	IDA	20603131, 22190748
GO:0048027	Function	MRNA 5'-UTR binding	IMP	21746880
GO:1990825	Function	Sequence-specific mRNA binding	IDA	22190748
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 611300
• HGNC: 24012
• e!Ensembl: ENSG00000166173

Protein

• UniProt ID: Q9BRS8
• Protein name: La-related protein 6 (Acheron) (Achn) (La ribonucleoprotein domain family member 6)
• Protein function: Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and t
• PDB: 2MTF , 2MTG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05383	La	96 → 154	La domain	Domain
  PF12901	SUZ-C	452 → 484	SUZ-C motif	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in numerous tissues. {ECO:0000269|PubMed:17383118}.
• Sequence:

  MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAGDPARYLSPGWGSASEE
  EPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEFYFSDENLEKDAFLLKHVR
  RNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLELNEDHRKVRRTTPVPLFPNEN
  LPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLLKLFGTFGVISSVRILKPGRELP
  PDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFMITESQGKENMKAVLIGMKPPKKKP
  AKDKNHDEEPTASIHLNKSLNKRVEELQYMGDESSANSSSDPESNPTSPMAGRRHAATNK
  LSPSGHQNLFLSPNASPCTSPWSSPLAQRKGVSRKSPLAEEGRLNCSTSPEIFRKCMDYS
  SDSSVTPSGSPWVRRRRQAEMGTQEKSPGTSPLLSRKMQTADGLPVGVLRLPRGPDNTRG
  FHGHERSRACV

• Sequence length: 491

Related Genes

No strongly related genes found yet for LARP6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to LARP6.