KNDC1 (kinase non-catalytic C-lobe domain containing 1)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 85442
• Gene name: Kinase non-catalytic C-lobe domain containing 1
• Gene symbol: KNDC1
• Synonyms (NCBI Gene): C10orf23, RASGEF2, Very-KIND, bB439H18.3, v-KIND
• Chromosome: 10
• Chromosome location: 10q26.3
• Summary: The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing

miRNA Show/Hide all (56)

miRTarBase ID	miRNA	Experiments	Reference
MIRT641265	hsa-miR-4432	HITS-CLIP	23824327
MIRT641264	hsa-miR-5695	HITS-CLIP	23824327
MIRT641263	hsa-miR-581	HITS-CLIP	23824327
MIRT641262	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT641265	hsa-miR-4432	HITS-CLIP	23824327
MIRT641264	hsa-miR-5695	HITS-CLIP	23824327
MIRT641263	hsa-miR-581	HITS-CLIP	23824327
MIRT641262	hsa-miR-550b-2-5p	HITS-CLIP	23824327
MIRT1099478	hsa-miR-1178	CLIP-seq
MIRT1099479	hsa-miR-128	CLIP-seq
MIRT1099480	hsa-miR-1321	CLIP-seq
MIRT1099481	hsa-miR-149	CLIP-seq
MIRT1099482	hsa-miR-24	CLIP-seq
MIRT1099483	hsa-miR-27a	CLIP-seq
MIRT1099484	hsa-miR-27b	CLIP-seq
MIRT1099485	hsa-miR-28-5p	CLIP-seq
MIRT1099486	hsa-miR-3139	CLIP-seq
MIRT1099487	hsa-miR-3157-5p	CLIP-seq
MIRT1099488	hsa-miR-3664-5p	CLIP-seq
MIRT1099489	hsa-miR-4270	CLIP-seq
MIRT1099490	hsa-miR-4284	CLIP-seq
MIRT1099491	hsa-miR-4328	CLIP-seq
MIRT1099492	hsa-miR-4441	CLIP-seq
MIRT1099493	hsa-miR-4633-3p	CLIP-seq
MIRT1099494	hsa-miR-4670-3p	CLIP-seq
MIRT1099495	hsa-miR-4691-3p	CLIP-seq
MIRT1099496	hsa-miR-4714-5p	CLIP-seq
MIRT1099497	hsa-miR-4739	CLIP-seq
MIRT1099498	hsa-miR-4756-5p	CLIP-seq
MIRT1099499	hsa-miR-513a-5p	CLIP-seq
MIRT1099500	hsa-miR-708	CLIP-seq
MIRT1099501	hsa-miR-765	CLIP-seq
MIRT2027005	hsa-miR-1207-5p	CLIP-seq
MIRT2027006	hsa-miR-1285	CLIP-seq
MIRT2027007	hsa-miR-3179	CLIP-seq
MIRT2027008	hsa-miR-3180-5p	CLIP-seq
MIRT2027009	hsa-miR-3184	CLIP-seq
MIRT2027010	hsa-miR-3187-5p	CLIP-seq
MIRT2027011	hsa-miR-3202	CLIP-seq
MIRT2027012	hsa-miR-3918	CLIP-seq
MIRT2027013	hsa-miR-423-5p	CLIP-seq
MIRT2027014	hsa-miR-4292	CLIP-seq
MIRT2027015	hsa-miR-4512	CLIP-seq
MIRT2027016	hsa-miR-4688	CLIP-seq
MIRT2027017	hsa-miR-4747-5p	CLIP-seq
MIRT2027018	hsa-miR-4763-3p	CLIP-seq
MIRT2027019	hsa-miR-4779	CLIP-seq
MIRT2027020	hsa-miR-612	CLIP-seq
MIRT2027021	hsa-miR-665	CLIP-seq
MIRT2258251	hsa-miR-1324	CLIP-seq
MIRT2258252	hsa-miR-3166	CLIP-seq
MIRT2258253	hsa-miR-3175	CLIP-seq
MIRT2258254	hsa-miR-3197	CLIP-seq
MIRT2258255	hsa-miR-3940-5p	CLIP-seq
MIRT2258256	hsa-miR-4269	CLIP-seq
MIRT2258257	hsa-miR-4507	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0021707	Process	Cerebellar granule cell differentiation	IEA
GO:0021707	Process	Cerebellar granule cell differentiation	ISS
GO:0030425	Component	Dendrite	IBA
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0032045	Component	Guanyl-nucleotide exchange factor complex	IBA
GO:0032045	Component	Guanyl-nucleotide exchange factor complex	IEA
GO:0032045	Component	Guanyl-nucleotide exchange factor complex	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0043204	Component	Perikaryon	IEA
GO:0048814	Process	Regulation of dendrite morphogenesis	IBA
GO:0048814	Process	Regulation of dendrite morphogenesis	IEA
GO:0048814	Process	Regulation of dendrite morphogenesis	ISS
GO:0050773	Process	Regulation of dendrite development	IEA
GO:0050773	Process	Regulation of dendrite development	ISS

Other IDs

• MIM: 616237
• HGNC: 29374
• e!Ensembl: ENSG00000171798

Protein

• UniProt ID: Q76NI1
• Protein name: Kinase non-catalytic C-lobe domain-containing protein 1 (KIND domain-containing protein 1) (Cerebral protein 9) (Protein very KIND) (v-KIND) (Ras-GEF domain-containing family member 2)
• Protein function: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similarity). May be involved in cellular senescence (PubMed:24788352). {ECO:
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00617	RasGEF	1472 → 1680	RasGEF domain	Family
  PF00618	RasGEF_N	1249 → 1348	RasGEF N-terminal motif	Domain
  PF16474	KIND	37 → 186	Kinase non-catalytic C-lobe domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed specifically in the cerebral cortex. {ECO:0000269|Ref.3}.
• Sequence:

  MQAMDPAAADLYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCL
  ECSLSMRSVAHAAIFQSLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDVTGNTFE
  AHIYSLGATLKAALEYVAEPTLEPRLSQDLEALLSRMQAEDPGDRPDLESIIALCEEKLQ
  LTSSCRVCRSLSAVGRRVLSIESFGALQDVSESSWRERPAPGNAGPRRPPGDPSTDPEVL
  PTPEGPESETSRGPRASPTKALLSTPVRNGESHSREGLAGLVLDAERTLGELDRDALRRS
  RLRKVQTFPRLLSDSPEATLCLPLTRGKSQLPISELFSPDPRKAFLDRKNGLSSFQAQPK
  CRLWPEQEPEHQLGRVPCAGRSTDRGPGVPGSPGQPETSHPSQGPAEAPADPRDASGEAQ
  TPRDDERIPEGARQLESAAAEQWVSLQDLLSQLGRPFREYELWALCLACLRALQTRPEHP
  AYLCLDSVLVAEDGAVLFQPPPANGSYDSFFLAPELAEERLVTEKASVYCVAAVLWTAAK
  FSVPRNHKLALPRRLKTLLLDMARRSAPERPSAAEAIKVCGSYLLQRGMDSRKILAHLRA
  SICQVYQEEETISLQNAFSVVELKPSVAPAPEPSPGFLPVNSDTGLVAVPGPVPGQHPCG
  EEATQLPAAFTSEATHFKPIVLAQNASVARDQPALAQEESEERGGQREGEGEEKLSLEAH
  AGSPSLKTPDGPVPGPGPQGAAPEPLGASVQRDSAQGRPCPPPQAPANQPEGASSAAPGS
  PVPAPPTKASALPVEQGPAEPIPPGVASGGLRPDALGPTTAHHGPRHPPKPPRSKATERP
  GQEPEGPGATPAGERDDQSPDSVPERPRPADRRLCLPCVDASPLPGRTACPSLQEATRLI
  QEEFAFDGYLDNGLEALIMGEYIFALKDLTFATFCGAISEKFCDLYWDEKLLQNLFKVVN
  GQASPSPSTAEEAGSQLEGSQSPRSPSSKRPSLHRLGKEKPAMARTSSRAPCSPTSVSDV
  DSDALSRGNFEVGFRPQRSVKAERAQQPEAGEDRRPAGGASDVEAVTRLARSKGVGPALS
  PGPAGFQSCSPGWCSAFYEADCFGADVHNYVKDLGRQQADGALPDAQSPELEQQLMMEKR
  NYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKKYLQVMYAERW
  GLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMA
  YLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSL
  CVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGNPR
  GTDLENPREAEEDARPFNALCKRLSEDGISRKSFPWRLPRGNGLVLPPHKERPYTIAAAL
  PKPCFLEDFYGPCAKTSEKGPYFLTEYSTHQLFSQLTLLQQELFQKCHPVHFLNSRALGV
  MDKSTAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKL
  QVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAVRQSPAWRILPAKIAEVMEELKAVE
  VFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVVS
  QVHAFQENPYTFSPDPKLQSYLKQRIARFSGADISTLAADSRANFHQVSSEKHSRKIQDK
  LRRMKATFQ

• Sequence length: 1749

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Breast ductal adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	32740652	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	36658621	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for KNDC1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to KNDC1.