KLHL6 (kelch like family member 6)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 89857
• Gene name: Kelch like family member 6
• Gene symbol: KLHL6
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q27.1
• Summary: This gene encodes a member of the kelch-like (KLHL) family of proteins, which is involved in B-lymphocyte antigen receptor signaling and germinal-center B-cell maturation. The encoded protein contains an N-terminal broad-complex, tramtrack and bric a brac

miRNA Show/Hide all (236)

miRTarBase ID	miRNA	Experiments	Reference
MIRT047570	hsa-miR-10a-5p	CLASH	23622248
MIRT1098748	hsa-miR-1228	CLIP-seq
MIRT1098749	hsa-miR-1231	CLIP-seq
MIRT1098750	hsa-miR-1254	CLIP-seq
MIRT1098751	hsa-miR-1290	CLIP-seq
MIRT1098752	hsa-miR-1302	CLIP-seq
MIRT1098753	hsa-miR-143	CLIP-seq
MIRT1098754	hsa-miR-1827	CLIP-seq
MIRT1098755	hsa-miR-1914	CLIP-seq
MIRT1098756	hsa-miR-2052	CLIP-seq
MIRT1098757	hsa-miR-24	CLIP-seq
MIRT1098758	hsa-miR-3116	CLIP-seq
MIRT1098759	hsa-miR-3120-5p	CLIP-seq
MIRT1098760	hsa-miR-3122	CLIP-seq
MIRT1098761	hsa-miR-3128	CLIP-seq
MIRT1098762	hsa-miR-3167	CLIP-seq
MIRT1098763	hsa-miR-3199	CLIP-seq
MIRT1098764	hsa-miR-335	CLIP-seq
MIRT1098765	hsa-miR-342-3p	CLIP-seq
MIRT1098766	hsa-miR-3661	CLIP-seq
MIRT1098767	hsa-miR-3664-3p	CLIP-seq
MIRT1098768	hsa-miR-371-5p	CLIP-seq
MIRT1098769	hsa-miR-371b-5p	CLIP-seq
MIRT1098770	hsa-miR-380	CLIP-seq
MIRT1098771	hsa-miR-3913-5p	CLIP-seq
MIRT1098772	hsa-miR-3924	CLIP-seq
MIRT1098773	hsa-miR-3929	CLIP-seq
MIRT1098774	hsa-miR-3937	CLIP-seq
MIRT1098775	hsa-miR-3974	CLIP-seq
MIRT1098776	hsa-miR-4252	CLIP-seq
MIRT1098777	hsa-miR-4257	CLIP-seq
MIRT1098778	hsa-miR-4284	CLIP-seq
MIRT1098779	hsa-miR-4298	CLIP-seq
MIRT1098780	hsa-miR-4311	CLIP-seq
MIRT1098781	hsa-miR-4419b	CLIP-seq
MIRT1098782	hsa-miR-4428	CLIP-seq
MIRT1098783	hsa-miR-4433	CLIP-seq
MIRT1098784	hsa-miR-4457	CLIP-seq
MIRT1098785	hsa-miR-4459	CLIP-seq
MIRT1098786	hsa-miR-4478	CLIP-seq
MIRT1098787	hsa-miR-4486	CLIP-seq
MIRT1098788	hsa-miR-4495	CLIP-seq
MIRT1098789	hsa-miR-451b	CLIP-seq
MIRT1098790	hsa-miR-4532	CLIP-seq
MIRT1098791	hsa-miR-4537	CLIP-seq
MIRT1098792	hsa-miR-4645-3p	CLIP-seq
MIRT1098793	hsa-miR-4649-3p	CLIP-seq
MIRT1098794	hsa-miR-4649-5p	CLIP-seq
MIRT1098795	hsa-miR-4664-3p	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT1098798	hsa-miR-4695-3p	CLIP-seq
MIRT1098799	hsa-miR-4695-5p	CLIP-seq
MIRT1098800	hsa-miR-4709-3p	CLIP-seq
MIRT1098801	hsa-miR-4719	CLIP-seq
MIRT1098802	hsa-miR-4720-5p	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT1098804	hsa-miR-4768-3p	CLIP-seq
MIRT1098805	hsa-miR-4770	CLIP-seq
MIRT1098806	hsa-miR-4778-5p	CLIP-seq
MIRT1098807	hsa-miR-4793-3p	CLIP-seq
MIRT1098808	hsa-miR-4799-3p	CLIP-seq
MIRT1098809	hsa-miR-485-5p	CLIP-seq
MIRT1098810	hsa-miR-508-5p	CLIP-seq
MIRT1098811	hsa-miR-510	CLIP-seq
MIRT1098812	hsa-miR-512-5p	CLIP-seq
MIRT1098813	hsa-miR-513b	CLIP-seq
MIRT1098814	hsa-miR-515-3p	CLIP-seq
MIRT1098815	hsa-miR-519e	CLIP-seq
MIRT1098816	hsa-miR-542-3p	CLIP-seq
MIRT1098817	hsa-miR-550a	CLIP-seq
MIRT1098818	hsa-miR-619	CLIP-seq
MIRT1098819	hsa-miR-624	CLIP-seq
MIRT1098820	hsa-miR-631	CLIP-seq
MIRT1098821	hsa-miR-661	CLIP-seq
MIRT1098822	hsa-miR-766	CLIP-seq
MIRT1098823	hsa-miR-876-5p	CLIP-seq
MIRT1098824	hsa-miR-940	CLIP-seq
MIRT1098750	hsa-miR-1254	CLIP-seq
MIRT1098758	hsa-miR-3116	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT1098814	hsa-miR-515-3p	CLIP-seq
MIRT1098815	hsa-miR-519e	CLIP-seq
MIRT1098817	hsa-miR-550a	CLIP-seq
MIRT1098821	hsa-miR-661	CLIP-seq
MIRT1098750	hsa-miR-1254	CLIP-seq
MIRT1098758	hsa-miR-3116	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT1098814	hsa-miR-515-3p	CLIP-seq
MIRT1098815	hsa-miR-519e	CLIP-seq
MIRT1098817	hsa-miR-550a	CLIP-seq
MIRT1098821	hsa-miR-661	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT2026833	hsa-miR-1245	CLIP-seq
MIRT1098750	hsa-miR-1254	CLIP-seq
MIRT2026834	hsa-miR-150	CLIP-seq
MIRT1098754	hsa-miR-1827	CLIP-seq
MIRT1098758	hsa-miR-3116	CLIP-seq
MIRT2026835	hsa-miR-3120-3p	CLIP-seq
MIRT2026836	hsa-miR-3140-3p	CLIP-seq
MIRT1098767	hsa-miR-3664-3p	CLIP-seq
MIRT2026837	hsa-miR-3667-3p	CLIP-seq
MIRT2026838	hsa-miR-370	CLIP-seq
MIRT2026839	hsa-miR-3925-3p	CLIP-seq
MIRT1098773	hsa-miR-3929	CLIP-seq
MIRT1098776	hsa-miR-4252	CLIP-seq
MIRT1098781	hsa-miR-4419b	CLIP-seq
MIRT1098783	hsa-miR-4433	CLIP-seq
MIRT1098785	hsa-miR-4459	CLIP-seq
MIRT1098786	hsa-miR-4478	CLIP-seq
MIRT1098793	hsa-miR-4649-3p	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT2026840	hsa-miR-4677-5p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT1098799	hsa-miR-4695-5p	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT1098804	hsa-miR-4768-3p	CLIP-seq
MIRT1098807	hsa-miR-4793-3p	CLIP-seq
MIRT2026841	hsa-miR-4793-5p	CLIP-seq
MIRT1098809	hsa-miR-485-5p	CLIP-seq
MIRT1098810	hsa-miR-508-5p	CLIP-seq
MIRT1098811	hsa-miR-510	CLIP-seq
MIRT1098812	hsa-miR-512-5p	CLIP-seq
MIRT1098814	hsa-miR-515-3p	CLIP-seq
MIRT1098815	hsa-miR-519e	CLIP-seq
MIRT1098817	hsa-miR-550a	CLIP-seq
MIRT2026842	hsa-miR-617	CLIP-seq
MIRT1098821	hsa-miR-661	CLIP-seq
MIRT1098822	hsa-miR-766	CLIP-seq
MIRT2026843	hsa-miR-885-3p	CLIP-seq
MIRT1098824	hsa-miR-940	CLIP-seq
MIRT2258057	hsa-miR-1200	CLIP-seq
MIRT2026833	hsa-miR-1245	CLIP-seq
MIRT1098750	hsa-miR-1254	CLIP-seq
MIRT2258058	hsa-miR-1297	CLIP-seq
MIRT2258059	hsa-miR-1976	CLIP-seq
MIRT2258060	hsa-miR-26a	CLIP-seq
MIRT2258061	hsa-miR-26b	CLIP-seq
MIRT1098758	hsa-miR-3116	CLIP-seq
MIRT1098775	hsa-miR-3974	CLIP-seq
MIRT1098776	hsa-miR-4252	CLIP-seq
MIRT1098777	hsa-miR-4257	CLIP-seq
MIRT2258062	hsa-miR-4324	CLIP-seq
MIRT1098784	hsa-miR-4457	CLIP-seq
MIRT2258063	hsa-miR-4465	CLIP-seq
MIRT1098787	hsa-miR-4486	CLIP-seq
MIRT1098790	hsa-miR-4532	CLIP-seq
MIRT1098791	hsa-miR-4537	CLIP-seq
MIRT2258064	hsa-miR-4635	CLIP-seq
MIRT1098794	hsa-miR-4649-5p	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT2258065	hsa-miR-4722-3p	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT2258066	hsa-miR-4779	CLIP-seq
MIRT1098807	hsa-miR-4793-3p	CLIP-seq
MIRT1098810	hsa-miR-508-5p	CLIP-seq
MIRT1098813	hsa-miR-513b	CLIP-seq
MIRT1098814	hsa-miR-515-3p	CLIP-seq
MIRT1098815	hsa-miR-519e	CLIP-seq
MIRT2258067	hsa-miR-520f	CLIP-seq
MIRT1098816	hsa-miR-542-3p	CLIP-seq
MIRT2258068	hsa-miR-544b	CLIP-seq
MIRT1098817	hsa-miR-550a	CLIP-seq
MIRT2258069	hsa-miR-583	CLIP-seq
MIRT1098819	hsa-miR-624	CLIP-seq
MIRT1098821	hsa-miR-661	CLIP-seq
MIRT2258070	hsa-miR-765	CLIP-seq
MIRT1098822	hsa-miR-766	CLIP-seq
MIRT1098750	hsa-miR-1254	CLIP-seq
MIRT1098758	hsa-miR-3116	CLIP-seq
MIRT1098796	hsa-miR-4677-3p	CLIP-seq
MIRT1098797	hsa-miR-4679	CLIP-seq
MIRT1098803	hsa-miR-4738-3p	CLIP-seq
MIRT1098814	hsa-miR-515-3p	CLIP-seq
MIRT1098815	hsa-miR-519e	CLIP-seq
MIRT1098817	hsa-miR-550a	CLIP-seq
MIRT1098821	hsa-miR-661	CLIP-seq
MIRT1098748	hsa-miR-1228	CLIP-seq
MIRT2452681	hsa-miR-1283	CLIP-seq
MIRT2452682	hsa-miR-203	CLIP-seq
MIRT1098764	hsa-miR-335	CLIP-seq
MIRT1098789	hsa-miR-451b	CLIP-seq
MIRT2258064	hsa-miR-4635	CLIP-seq
MIRT2452683	hsa-miR-4662a-5p	CLIP-seq
MIRT2452684	hsa-miR-4676-5p	CLIP-seq
MIRT2452685	hsa-miR-4684-5p	CLIP-seq
MIRT2452686	hsa-miR-4755-3p	CLIP-seq
MIRT2452687	hsa-miR-526b	CLIP-seq
MIRT2452688	hsa-miR-548a-3p	CLIP-seq
MIRT2452689	hsa-miR-548e	CLIP-seq
MIRT2452690	hsa-miR-548f	CLIP-seq
MIRT2452691	hsa-miR-575	CLIP-seq
MIRT2452692	hsa-miR-578	CLIP-seq
MIRT2452681	hsa-miR-1283	CLIP-seq
MIRT2452685	hsa-miR-4684-5p	CLIP-seq
MIRT2452688	hsa-miR-548a-3p	CLIP-seq
MIRT2452689	hsa-miR-548e	CLIP-seq
MIRT2452690	hsa-miR-548f	CLIP-seq
MIRT1098748	hsa-miR-1228	CLIP-seq
MIRT2452681	hsa-miR-1283	CLIP-seq
MIRT2258058	hsa-miR-1297	CLIP-seq
MIRT2026834	hsa-miR-150	CLIP-seq
MIRT2258060	hsa-miR-26a	CLIP-seq
MIRT2258061	hsa-miR-26b	CLIP-seq
MIRT2559006	hsa-miR-4426	CLIP-seq
MIRT2258063	hsa-miR-4465	CLIP-seq
MIRT2559007	hsa-miR-4647	CLIP-seq
MIRT2452683	hsa-miR-4662a-5p	CLIP-seq
MIRT2559008	hsa-miR-4662b	CLIP-seq
MIRT2452684	hsa-miR-4676-5p	CLIP-seq
MIRT2452685	hsa-miR-4684-5p	CLIP-seq
MIRT2452686	hsa-miR-4755-3p	CLIP-seq
MIRT2452688	hsa-miR-548a-3p	CLIP-seq
MIRT2452689	hsa-miR-548e	CLIP-seq
MIRT2452690	hsa-miR-548f	CLIP-seq
MIRT2452691	hsa-miR-575	CLIP-seq
MIRT1098748	hsa-miR-1228	CLIP-seq
MIRT2452681	hsa-miR-1283	CLIP-seq
MIRT2559006	hsa-miR-4426	CLIP-seq
MIRT2559007	hsa-miR-4647	CLIP-seq
MIRT2452683	hsa-miR-4662a-5p	CLIP-seq
MIRT2559008	hsa-miR-4662b	CLIP-seq
MIRT2452684	hsa-miR-4676-5p	CLIP-seq
MIRT2452685	hsa-miR-4684-5p	CLIP-seq
MIRT2452686	hsa-miR-4755-3p	CLIP-seq
MIRT2452688	hsa-miR-548a-3p	CLIP-seq
MIRT2452689	hsa-miR-548e	CLIP-seq
MIRT2452690	hsa-miR-548f	CLIP-seq
MIRT2452691	hsa-miR-575	CLIP-seq

Gene ontology (GO) Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002467	Process	Germinal center formation	IEA
GO:0005515	Function	Protein binding	IPI	25036637, 25416956, 26871637, 28514442, 32296183, 32814053, 33961781, 35512704
GO:0005737	Component	Cytoplasm	IBA
GO:0009617	Process	Response to bacterium	IEA
GO:0031463	Component	Cul3-RING ubiquitin ligase complex	IBA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0050853	Process	B cell receptor signaling pathway	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IBA

Other IDs

• MIM: 614214
• HGNC: 18653
• e!Ensembl: ENSG00000172578

Protein

• UniProt ID: Q8WZ60
• Protein name: Kelch-like protein 6
• Protein function: Involved in B-lymphocyte antigen receptor signaling and germinal center formation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	62 → 169	BTB/POZ domain	Domain
  PF01344	Kelch_1	411 → 455	Kelch motif	Repeat
  PF01344	Kelch_1	457 → 503	Kelch motif	Repeat
  PF01344	Kelch_1	547 → 587	Kelch motif	Repeat
  PF07707	BACK	174 → 276	BTB And C-terminal Kelch	Domain

• Tissue specificity: TISSUE SPECIFICITY: Found in germinal center B-cells. {ECO:0000269|PubMed:12617994}.
• Sequence:

  MLMAGQRGAWTMGDVVEKSLEGPLAPSTDEPSQKTGDLVEILNGEKVKFDDAGLSLILQN
  GLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA
  ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL
  ADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVM
  SWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLS
  GNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHEL
  ESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLG
  GKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGK
  LATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLEDSWCL
  VTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHG
  SVTIRKSYTHIRRIVPGAVSV

• Sequence length: 621

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	39998322	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	37315093	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Monoclonal B-Cell Lymphocytosis	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	CTD, Disgenet CTD, Disgenet	31068361	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SAPHO SYNDROME	—	GWAS catalog	33816493	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (13)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	29695787, 30646831		★☆☆☆☆ Found in Text Mining only
B-Cell Lymphomas	B-Cell Lymphoma	BEFREE	28807996, 29140403, 30646831		★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	30924136		★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	29695787, 29738359, 30646831		★☆☆☆☆ Found in Text Mining only
Gastritis, Atrophic	Gastritis	BEFREE	29044464		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	37475138	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma Follicular	Lymphoma	Pubtator	22585168, 29140403	Associate	★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	29140403		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29044464		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30646831		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	29884741	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29695787, 30646831		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29044464		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

CDK17 2 shared evidence sourcesDisgenet (Multiple sclerosis), CTD (Multiple sclerosis) Related via 2 shared evidence sources. DUSP28 2 shared evidence sourcesDisgenet (Multiple sclerosis), CTD (Multiple sclerosis) Related via 2 shared evidence sources. SYS1 2 shared evidence sourcesDisgenet (Multiple sclerosis), CTD (Multiple sclerosis) Related via 2 shared evidence sources. AIM2 2 shared evidence sourcesDisgenet (Multiple sclerosis), CTD (Multiple sclerosis) Related via 2 shared evidence sources. NABP1 2 shared evidence sourcesDisgenet (Multiple sclerosis), CTD (Multiple sclerosis) Related via 2 shared evidence sources.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
CDK17	0	[]	0	[]	2	["Disgenet (Multiple sclerosis)","CTD (Multiple sclerosis)"]
DUSP28	0	[]	0	[]	2	["Disgenet (Multiple sclerosis)","CTD (Multiple sclerosis)"]
SYS1	0	[]	0	[]	2	["Disgenet (Multiple sclerosis)","CTD (Multiple sclerosis)"]
AIM2	0	[]	0	[]	2	["Disgenet (Multiple sclerosis)","CTD (Multiple sclerosis)"]
NABP1	0	[]	0	[]	2	["Disgenet (Multiple sclerosis)","CTD (Multiple sclerosis)"]

Diseases Linked via Similar Genes

Psoriasis Linked via 2 of 5 related genesSYS1, AIM2 Scoliosis Linked via 2 of 5 related genesAIM2, NABP1 Venous thromboembolism Linked via 1 of 5 related genesCDK17 Asthma Linked via 1 of 5 related genesAIM2 Bipolar disorder Linked via 1 of 5 related genesAIM2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Psoriasis	2	["SYS1","AIM2"]
Scoliosis	2	["AIM2","NABP1"]
Venous thromboembolism	1	["CDK17"]
Asthma	1	["AIM2"]
Bipolar disorder	1	["AIM2"]