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Gene Gene information from NCBI Gene database.
Entrez ID 55175
Gene name Kelch like family member 11
Gene symbol KLHL11
Synonyms (NCBI Gene)
-
Chromosome 17
Chromosome location 17q21.2
miRNA miRNA information provided by mirtarbase database.
549 Show/Hide all (549)
miRTarBase ID miRNA Experiments Reference
MIRT018273 hsa-miR-335-5p Microarray 18185580
MIRT052056 hsa-let-7b-5p CLASH 23622248
MIRT049484 hsa-miR-92a-3p CLASH 23622248
MIRT040230 hsa-miR-615-3p CLASH 23622248
MIRT474452 hsa-miR-520g-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6 Show/Hide all (6)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005829 Component Cytosol TAS
GO:0031463 Component Cul3-RING ubiquitin ligase complex IBA
GO:0043161 Process Proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619078 19008 ENSG00000178502
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NVR0
Protein name Kelch-like protein 11
Protein function Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.
PDB 3I3N , 4AP2 , 4APF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 84 → 200 BTB/POZ domain Domain
PF01344 Kelch_1 442 → 488 Kelch motif Repeat
PF07707 BACK 205 → 307 BTB And C-terminal Kelch Domain
Sequence
MAAAAVAAAAAAAAAASLQVLEMESMETAAAGSAGLAAEVRGSGTVDFGPGPGISAMEAS
GGDPGPEAEDFECSSHCSELSWRQNEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATE
YFTPLLSGQFSESRSGRVEMRKWSSEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELA
DRFLLIRLKEFCGEFLKKKL
HLSNCVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDEE
FYTLPFHLIRDWLSDLEITVDSEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPT
YLTRHVK
PERLVANNEVCVKLVADAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDV
IMVIGGVSEGGDYLSECVGYFVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA
KTVERYNPNLNTWEHVCSLMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDK
WHNLESAP
KILRDVKALAIEDRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESL
PLIDNYCFFQMSVVNSNFYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIE
GAAICYYKDDVFIIGGWKNSDDIDKQYRKEAYRYCAERKRWMLLPPMPQPRCRATACHVR
IPYRYLHGTQRYPMPQNLMWQKDRIRQMQEIHRHALNMRRVPSSQIEC
Sequence length 708
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (6)
Phenotype Name Clinical Significance Source Reference Evidence Score
Acute myeloid leukemia Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colorectal cancer Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Melanoma Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (6)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Ataxia Ataxia Pubtator 32744608 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 18360708 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Dysarthria Dysarthria Pubtator 32744608 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Encephalitis Encephalitis Pubtator 32744608 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Hearing Loss Hearing loss Pubtator 32744608 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Seizures Seizures Pubtator 32744608 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only