KLHDC8A (kelch domain containing 8A)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55220
• Gene name: Kelch domain containing 8A
• Gene symbol: KLHDC8A
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This gene encodes a kelch domain-containing protein which is upregulated in cancer. Upregulated expression of the encoded protein may provide an alternative pathway for tumors to maintain aggressiveness in the absence of epidermal growth factor receptor d

miRNA Show/Hide all (197)

miRTarBase ID	miRNA	Experiments	Reference
MIRT676924	hsa-miR-764	HITS-CLIP	23824327
MIRT676923	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676922	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676921	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676920	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676919	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676918	hsa-miR-640	HITS-CLIP	23824327
MIRT676917	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676916	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT673244	hsa-miR-3667-5p	HITS-CLIP	23824327
MIRT673243	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT673242	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT673241	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT673240	hsa-miR-451b	HITS-CLIP	23824327
MIRT673239	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT673238	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT673237	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT673236	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT673235	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT673234	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673233	hsa-miR-4421	HITS-CLIP	23824327
MIRT673232	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT673231	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT673230	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT673229	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT673228	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT673227	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT673226	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT673225	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT673224	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT673223	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT673222	hsa-miR-612	HITS-CLIP	23824327
MIRT673221	hsa-miR-6860	HITS-CLIP	23824327
MIRT673220	hsa-miR-4725-5p	HITS-CLIP	23824327
MIRT673219	hsa-miR-4696	HITS-CLIP	23824327
MIRT673218	hsa-miR-196a-3p	HITS-CLIP	23824327
MIRT673217	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT673216	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT673215	hsa-miR-7703	HITS-CLIP	23824327
MIRT474540	hsa-miR-890	PAR-CLIP	23592263
MIRT474539	hsa-miR-7155-5p	PAR-CLIP	23592263
MIRT474538	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT474537	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT474536	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT474535	hsa-miR-4505	PAR-CLIP	23592263
MIRT474534	hsa-miR-5787	PAR-CLIP	23592263
MIRT474533	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT474532	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT474531	hsa-miR-342-5p	PAR-CLIP	23592263
MIRT474530	hsa-miR-4664-5p	PAR-CLIP	23592263
MIRT474529	hsa-miR-4651	PAR-CLIP	23592263
MIRT474528	hsa-miR-608	PAR-CLIP	23592263
MIRT474526	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT474527	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT474525	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT474524	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT474523	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT474522	hsa-miR-1273e	PAR-CLIP	23592263
MIRT474521	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT474520	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT474519	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT474518	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT474517	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT474516	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT474515	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT474514	hsa-miR-3689c	PAR-CLIP	23592263
MIRT474513	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT474512	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT474511	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT474510	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT474509	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT474508	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT676924	hsa-miR-764	HITS-CLIP	23824327
MIRT676923	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676922	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676921	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676920	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676919	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT676918	hsa-miR-640	HITS-CLIP	23824327
MIRT676917	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676916	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT673244	hsa-miR-3667-5p	HITS-CLIP	23824327
MIRT673243	hsa-miR-10a-5p	HITS-CLIP	23824327
MIRT673242	hsa-miR-10b-5p	HITS-CLIP	23824327
MIRT673241	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT673240	hsa-miR-451b	HITS-CLIP	23824327
MIRT673239	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT673238	hsa-miR-6501-3p	HITS-CLIP	23824327
MIRT673237	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT673236	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT673235	hsa-miR-339-5p	HITS-CLIP	23824327
MIRT673234	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673233	hsa-miR-4421	HITS-CLIP	23824327
MIRT673232	hsa-miR-5699-3p	HITS-CLIP	23824327
MIRT673231	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT673230	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT673229	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT673228	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT673227	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT673226	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT673225	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT673224	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT673223	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT673222	hsa-miR-612	HITS-CLIP	23824327
MIRT673221	hsa-miR-6860	HITS-CLIP	23824327
MIRT673220	hsa-miR-4725-5p	HITS-CLIP	23824327
MIRT673219	hsa-miR-4696	HITS-CLIP	23824327
MIRT673218	hsa-miR-196a-3p	HITS-CLIP	23824327
MIRT673217	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT673216	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT673215	hsa-miR-7703	HITS-CLIP	23824327
MIRT474540	hsa-miR-890	PAR-CLIP	23592263
MIRT474539	hsa-miR-7155-5p	PAR-CLIP	23592263
MIRT474538	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT474537	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT474536	hsa-miR-6894-5p	PAR-CLIP	23592263
MIRT474535	hsa-miR-4505	PAR-CLIP	23592263
MIRT474534	hsa-miR-5787	PAR-CLIP	23592263
MIRT474533	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT474532	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT474531	hsa-miR-342-5p	PAR-CLIP	23592263
MIRT474530	hsa-miR-4664-5p	PAR-CLIP	23592263
MIRT474529	hsa-miR-4651	PAR-CLIP	23592263
MIRT474528	hsa-miR-608	PAR-CLIP	23592263
MIRT474526	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT474527	hsa-miR-6756-5p	PAR-CLIP	23592263
MIRT474525	hsa-miR-6766-5p	PAR-CLIP	23592263
MIRT474524	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT474523	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT474522	hsa-miR-1273e	PAR-CLIP	23592263
MIRT474521	hsa-miR-30c-1-3p	PAR-CLIP	23592263
MIRT474520	hsa-miR-30c-2-3p	PAR-CLIP	23592263
MIRT474519	hsa-miR-6788-5p	PAR-CLIP	23592263
MIRT474518	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT474517	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT474516	hsa-miR-3689a-3p	PAR-CLIP	23592263
MIRT474515	hsa-miR-3689b-3p	PAR-CLIP	23592263
MIRT474514	hsa-miR-3689c	PAR-CLIP	23592263
MIRT474513	hsa-miR-6779-5p	PAR-CLIP	23592263
MIRT474512	hsa-miR-6780a-5p	PAR-CLIP	23592263
MIRT474511	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT474510	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT474509	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT474508	hsa-miR-887-5p	PAR-CLIP	23592263
MIRT755666	hsa-miR-128-3p	Luciferase reporter assay, Western blotting, qRT-PCR	37814858
MIRT1097403	hsa-let-7a	CLIP-seq
MIRT1097404	hsa-let-7b	CLIP-seq
MIRT1097405	hsa-let-7c	CLIP-seq
MIRT1097406	hsa-let-7d	CLIP-seq
MIRT1097407	hsa-let-7e	CLIP-seq
MIRT1097408	hsa-let-7f	CLIP-seq
MIRT1097409	hsa-let-7g	CLIP-seq
MIRT1097410	hsa-let-7i	CLIP-seq
MIRT1097411	hsa-miR-1270	CLIP-seq
MIRT1097412	hsa-miR-1273f	CLIP-seq
MIRT1097413	hsa-miR-136	CLIP-seq
MIRT1097414	hsa-miR-1914	CLIP-seq
MIRT1097415	hsa-miR-3689d	CLIP-seq
MIRT1097416	hsa-miR-3690	CLIP-seq
MIRT1097417	hsa-miR-4254	CLIP-seq
MIRT1097418	hsa-miR-4419a	CLIP-seq
MIRT1097419	hsa-miR-4447	CLIP-seq
MIRT1097420	hsa-miR-4458	CLIP-seq
MIRT1097421	hsa-miR-4459	CLIP-seq
MIRT1097422	hsa-miR-4472	CLIP-seq
MIRT1097423	hsa-miR-4496	CLIP-seq
MIRT1097424	hsa-miR-4500	CLIP-seq
MIRT1097425	hsa-miR-4510	CLIP-seq
MIRT1097426	hsa-miR-4683	CLIP-seq
MIRT1097427	hsa-miR-4723-5p	CLIP-seq
MIRT1097428	hsa-miR-4779	CLIP-seq
MIRT1097429	hsa-miR-4793-5p	CLIP-seq
MIRT1097430	hsa-miR-515-5p	CLIP-seq
MIRT1097431	hsa-miR-550a	CLIP-seq
MIRT1097432	hsa-miR-620	CLIP-seq
MIRT1097433	hsa-miR-98	CLIP-seq
MIRT2026437	hsa-miR-1184	CLIP-seq
MIRT2026438	hsa-miR-1205	CLIP-seq
MIRT2026439	hsa-miR-1207-3p	CLIP-seq
MIRT2026440	hsa-miR-1301	CLIP-seq
MIRT2026441	hsa-miR-138	CLIP-seq
MIRT2026442	hsa-miR-2110	CLIP-seq
MIRT2026443	hsa-miR-3153	CLIP-seq
MIRT2026444	hsa-miR-3158-5p	CLIP-seq
MIRT2026445	hsa-miR-3165	CLIP-seq
MIRT2026446	hsa-miR-3194-3p	CLIP-seq
MIRT2026447	hsa-miR-4271	CLIP-seq
MIRT2026448	hsa-miR-4456	CLIP-seq
MIRT2026449	hsa-miR-4487	CLIP-seq
MIRT2026450	hsa-miR-4660	CLIP-seq
MIRT2026451	hsa-miR-4667-5p	CLIP-seq
MIRT2026452	hsa-miR-4700-5p	CLIP-seq
MIRT2026453	hsa-miR-4725-3p	CLIP-seq
MIRT2026454	hsa-miR-4731-5p	CLIP-seq
MIRT2026455	hsa-miR-5047	CLIP-seq
MIRT2026456	hsa-miR-759	CLIP-seq
MIRT2026448	hsa-miR-4456	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25036637, 28514442, 33961781

Other IDs

• MIM: 614503
• HGNC: 25573
• e!Ensembl: ENSG00000162873

Protein

• UniProt ID: Q8IYD2
• Protein name: Kelch domain-containing protein 8A (Substitute for delta-EGFR expression 1) (S-delta-E1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01344	Kelch_1	20 → 66	Kelch motif	Repeat
  PF01344	Kelch_1	267 → 313	Kelch motif	Repeat
  PF01344	Kelch_1	68 → 111	Kelch motif	Repeat
  PF13964	Kelch_6	164 → 212		Repeat

• Sequence:

  MEVPNVKDFQWKRLAPLPSRRVYCSLLETGGQVYAIGGCDDNGVPMDCFEVYSPEADQWT
  ALPRLPTARAGVAVTALGKRIMVIGGVGTNQLPLKVVEMYNIDEGKWKKRSMLREAAMGI
  SVTAKDYRVYAAGGMGLDLRPHNHLQHYDMLKDMWVSLAPMPTPRYAATSFLRGSKIYVL
  GGRQSKYAVNAFEVFDIETRSWTKFPNIPYKRAFSSFVTLDNHLYSLGGLRQGRLYRQPK
  FLRTMDVFDMEQGGWLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGNQPTVLETAEAFH
  PGKNKWEILPAMPTPRCACSSIVVKNCLLAVGGVNQGLSDAVEALCVSDS

• Sequence length: 350

Related Genes

No strongly related genes found yet for KLHDC8A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to KLHDC8A.