KLHDC3 (kelch domain containing 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 116138
• Gene name: Kelch domain containing 3
• Gene symbol: KLHDC3
• Synonyms (NCBI Gene): PEAS, dJ20C7.3
• Chromosome: 6
• Chromosome location: 6p21.1
• Summary: The protein encoded by this gene contains six repeated kelch motifs that are structurally similar to recombination activating gene 2, a protein involved in the activation of the V(D)J recombination. In mouse, this gene is found to be expressed specificall

miRNA Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030532	hsa-miR-24-3p	Microarray	19748357
MIRT045462	hsa-miR-149-5p	CLASH	23622248
MIRT043209	hsa-miR-324-5p	CLASH	23622248
MIRT038971	hsa-miR-20a-3p	CLASH	23622248
MIRT038784	hsa-miR-93-3p	CLASH	23622248
MIRT036861	hsa-miR-877-3p	CLASH	23622248
MIRT239223	hsa-miR-6800-3p	PAR-CLIP	23592263
MIRT239221	hsa-miR-3925-5p	PAR-CLIP	23592263
MIRT219116	hsa-miR-3919	PAR-CLIP	23592263
MIRT474581	hsa-miR-181a-2-3p	PAR-CLIP	23592263
MIRT474580	hsa-miR-4286	PAR-CLIP	23592263
MIRT219119	hsa-miR-4680-3p	PAR-CLIP	23592263
MIRT474579	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT474578	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT474577	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT219118	hsa-miR-4452	PAR-CLIP	23592263
MIRT474576	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT474575	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT474574	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT474573	hsa-miR-665	PAR-CLIP	23592263
MIRT474572	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT474570	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT474571	hsa-miR-646	PAR-CLIP	23592263
MIRT474569	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT474567	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT474568	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT474566	hsa-miR-4766-5p	PAR-CLIP	23592263
MIRT474565	hsa-miR-5681a	PAR-CLIP	23592263
MIRT474564	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT474563	hsa-miR-3179	PAR-CLIP	23592263
MIRT474562	hsa-miR-3663-3p	PAR-CLIP	23592263
MIRT474561	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT474560	hsa-miR-6134	PAR-CLIP	23592263
MIRT474559	hsa-miR-6081	PAR-CLIP	23592263
MIRT474558	hsa-miR-3689d	PAR-CLIP	23592263
MIRT474556	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT474557	hsa-miR-1193	PAR-CLIP	23592263
MIRT474554	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT474555	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT474553	hsa-miR-4271	PAR-CLIP	23592263
MIRT474552	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT474551	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT474550	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT474549	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT474548	hsa-miR-4652-5p	PAR-CLIP	23592263
MIRT474547	hsa-miR-3165	PAR-CLIP	23592263
MIRT474546	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT474545	hsa-miR-488-3p	PAR-CLIP	23592263
MIRT474544	hsa-miR-432-3p	PAR-CLIP	23592263
MIRT474543	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT474542	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT474541	hsa-miR-3181	PAR-CLIP	23592263
MIRT474581	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT474581	hsa-miR-181a-2-3p	PAR-CLIP	26701625
MIRT474578	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT474578	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT474577	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT474577	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT219116	hsa-miR-3919	PAR-CLIP	26701625
MIRT219116	hsa-miR-3919	PAR-CLIP	26701625
MIRT239221	hsa-miR-3925-5p	PAR-CLIP	26701625
MIRT239221	hsa-miR-3925-5p	PAR-CLIP	26701625
MIRT474580	hsa-miR-4286	PAR-CLIP	26701625
MIRT474580	hsa-miR-4286	PAR-CLIP	26701625
MIRT219118	hsa-miR-4452	PAR-CLIP	26701625
MIRT219118	hsa-miR-4452	PAR-CLIP	26701625
MIRT219119	hsa-miR-4680-3p	PAR-CLIP	26701625
MIRT219119	hsa-miR-4680-3p	PAR-CLIP	26701625
MIRT474579	hsa-miR-513a-5p	PAR-CLIP	26701625
MIRT474579	hsa-miR-513a-5p	PAR-CLIP	26701625
MIRT239223	hsa-miR-6800-3p	PAR-CLIP	26701625
MIRT239223	hsa-miR-6800-3p	PAR-CLIP	26701625
MIRT239223	hsa-miR-6800-3p	PAR-CLIP	23592263
MIRT239221	hsa-miR-3925-5p	PAR-CLIP	23592263
MIRT219116	hsa-miR-3919	PAR-CLIP	23592263
MIRT474581	hsa-miR-181a-2-3p	PAR-CLIP	23592263
MIRT474580	hsa-miR-4286	PAR-CLIP	23592263
MIRT219119	hsa-miR-4680-3p	PAR-CLIP	23592263
MIRT474579	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT474578	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT474577	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT219118	hsa-miR-4452	PAR-CLIP	23592263
MIRT474576	hsa-miR-29b-3p	PAR-CLIP	23592263
MIRT474575	hsa-miR-29a-3p	PAR-CLIP	23592263
MIRT474574	hsa-miR-29c-3p	PAR-CLIP	23592263
MIRT474573	hsa-miR-665	PAR-CLIP	23592263
MIRT474572	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT474570	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT474571	hsa-miR-646	PAR-CLIP	23592263
MIRT474569	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT474567	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT474568	hsa-miR-6840-3p	PAR-CLIP	23592263
MIRT474566	hsa-miR-4766-5p	PAR-CLIP	23592263
MIRT474565	hsa-miR-5681a	PAR-CLIP	23592263
MIRT474564	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT474563	hsa-miR-3179	PAR-CLIP	23592263
MIRT474562	hsa-miR-3663-3p	PAR-CLIP	23592263
MIRT474561	hsa-miR-5008-5p	PAR-CLIP	23592263
MIRT474560	hsa-miR-6134	PAR-CLIP	23592263
MIRT474559	hsa-miR-6081	PAR-CLIP	23592263
MIRT474558	hsa-miR-3689d	PAR-CLIP	23592263
MIRT474556	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT474557	hsa-miR-1193	PAR-CLIP	23592263
MIRT474554	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT474555	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT474553	hsa-miR-4271	PAR-CLIP	23592263
MIRT474552	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT474551	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT474550	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT474549	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT474548	hsa-miR-4652-5p	PAR-CLIP	23592263
MIRT474547	hsa-miR-3165	PAR-CLIP	23592263
MIRT474546	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT474545	hsa-miR-488-3p	PAR-CLIP	23592263
MIRT474544	hsa-miR-432-3p	PAR-CLIP	23592263
MIRT474543	hsa-miR-6810-5p	PAR-CLIP	23592263
MIRT474542	hsa-miR-30b-3p	PAR-CLIP	23592263
MIRT474541	hsa-miR-3181	PAR-CLIP	23592263
MIRT1097141	hsa-miR-3922-5p	CLIP-seq
MIRT1097142	hsa-miR-4779	CLIP-seq
MIRT1097143	hsa-miR-1207-5p	CLIP-seq
MIRT1097144	hsa-miR-1262	CLIP-seq
MIRT1097145	hsa-miR-1909	CLIP-seq
MIRT1097146	hsa-miR-2467-3p	CLIP-seq
MIRT1097147	hsa-miR-27a	CLIP-seq
MIRT1097148	hsa-miR-27b	CLIP-seq
MIRT1097149	hsa-miR-29a	CLIP-seq
MIRT1097150	hsa-miR-29b	CLIP-seq
MIRT1097151	hsa-miR-29c	CLIP-seq
MIRT1097152	hsa-miR-3202	CLIP-seq
MIRT1097153	hsa-miR-34a	CLIP-seq
MIRT1097154	hsa-miR-34c-5p	CLIP-seq
MIRT1097155	hsa-miR-3665	CLIP-seq
MIRT1097156	hsa-miR-3691-3p	CLIP-seq
MIRT1097141	hsa-miR-3922-5p	CLIP-seq
MIRT1097157	hsa-miR-449a	CLIP-seq
MIRT1097158	hsa-miR-449b	CLIP-seq
MIRT1097159	hsa-miR-4685-5p	CLIP-seq
MIRT1097160	hsa-miR-4688	CLIP-seq
MIRT1097161	hsa-miR-4699-5p	CLIP-seq
MIRT1097162	hsa-miR-4701-3p	CLIP-seq
MIRT1097163	hsa-miR-4728-5p	CLIP-seq
MIRT1097164	hsa-miR-4763-3p	CLIP-seq
MIRT1097165	hsa-miR-486-3p	CLIP-seq
MIRT1097166	hsa-miR-542-3p	CLIP-seq
MIRT1097147	hsa-miR-27a	CLIP-seq
MIRT1097148	hsa-miR-27b	CLIP-seq
MIRT1097143	hsa-miR-1207-5p	CLIP-seq
MIRT1097144	hsa-miR-1262	CLIP-seq
MIRT1097145	hsa-miR-1909	CLIP-seq
MIRT2026294	hsa-miR-214	CLIP-seq
MIRT2026295	hsa-miR-2277-3p	CLIP-seq
MIRT2026296	hsa-miR-24	CLIP-seq
MIRT2026297	hsa-miR-3064-5p	CLIP-seq
MIRT2026298	hsa-miR-3155	CLIP-seq
MIRT2026299	hsa-miR-3155b	CLIP-seq
MIRT1097152	hsa-miR-3202	CLIP-seq
MIRT1097153	hsa-miR-34a	CLIP-seq
MIRT1097154	hsa-miR-34c-5p	CLIP-seq
MIRT2026300	hsa-miR-3619-5p	CLIP-seq
MIRT2026301	hsa-miR-3664-3p	CLIP-seq
MIRT1097155	hsa-miR-3665	CLIP-seq
MIRT1097141	hsa-miR-3922-5p	CLIP-seq
MIRT2026302	hsa-miR-4433	CLIP-seq
MIRT2026303	hsa-miR-4459	CLIP-seq
MIRT1097157	hsa-miR-449a	CLIP-seq
MIRT1097158	hsa-miR-449b	CLIP-seq
MIRT2026304	hsa-miR-4649-3p	CLIP-seq
MIRT2026305	hsa-miR-4686	CLIP-seq
MIRT1097160	hsa-miR-4688	CLIP-seq
MIRT2026306	hsa-miR-4690-5p	CLIP-seq
MIRT1097161	hsa-miR-4699-5p	CLIP-seq
MIRT1097162	hsa-miR-4701-3p	CLIP-seq
MIRT1097164	hsa-miR-4763-3p	CLIP-seq
MIRT2026307	hsa-miR-4768-3p	CLIP-seq
MIRT2026308	hsa-miR-4772-3p	CLIP-seq
MIRT1097142	hsa-miR-4779	CLIP-seq
MIRT2026309	hsa-miR-484	CLIP-seq
MIRT1097165	hsa-miR-486-3p	CLIP-seq
MIRT1097166	hsa-miR-542-3p	CLIP-seq
MIRT2026310	hsa-miR-761	CLIP-seq
MIRT2026311	hsa-miR-891b	CLIP-seq
MIRT2257429	hsa-miR-3136-3p	CLIP-seq
MIRT2257430	hsa-miR-3914	CLIP-seq
MIRT1097141	hsa-miR-3922-5p	CLIP-seq
MIRT2257431	hsa-miR-3928	CLIP-seq
MIRT2257432	hsa-miR-3943	CLIP-seq
MIRT2257433	hsa-miR-4323	CLIP-seq
MIRT2026304	hsa-miR-4649-3p	CLIP-seq
MIRT1097161	hsa-miR-4699-5p	CLIP-seq
MIRT2257434	hsa-miR-4723-5p	CLIP-seq
MIRT2257435	hsa-miR-548v	CLIP-seq
MIRT2026304	hsa-miR-4649-3p	CLIP-seq
MIRT2257435	hsa-miR-548v	CLIP-seq
MIRT2558650	hsa-miR-3160-3p	CLIP-seq
MIRT2026304	hsa-miR-4649-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	12606021
GO:0000785	Component	Chromatin	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	12606021
GO:0003682	Function	Chromatin binding	IEA
GO:0005515	Function	Protein binding	IPI	12482870, 21145461, 28514442, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12606021
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0007131	Process	Reciprocal meiotic recombination	NAS	12606021
GO:0016567	Process	Protein ubiquitination	IEA
GO:0031462	Component	Cul2-RING ubiquitin ligase complex	IDA	26138980, 29779948
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	26138980
GO:0051321	Process	Meiotic cell cycle	IEA
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA	29779948
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	26138980, 29779948

Other IDs

• MIM: 611248
• HGNC: 20704
• e!Ensembl: ENSG00000124702

Protein

• UniProt ID: Q9BQ90
• Protein name: Kelch domain-containing protein 3 (Testis intracellular mediator protein)
• Protein function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their
• PDB: 9D1I , 9D1Y , 9D1Z
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07646	Kelch_2	127 → 174	Kelch motif	Repeat
  PF07646	Kelch_2	179 → 233	Kelch motif	Repeat
  PF13418	Kelch_4	76 → 126		Repeat
  PF13964	Kelch_6	238 → 293		Repeat
  PF13964	Kelch_6	13 → 67		Repeat

• Sequence:

  MLRWTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLP
  PVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRV
  SGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWR
  DFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRR
  SHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVG
  DKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDI
  RWELNAMTTNSNISRPIVSSHG

• Sequence length: 382

Pathways

Reactome Pathway:

XBP1(S) activates chaperone genes

Related Genes

No strongly related genes found yet for KLHDC3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to KLHDC3.