KIN (Kin17 DNA and RNA binding protein)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 22944
• Gene name: Kin17 DNA and RNA binding protein
• Gene symbol: KIN
• Synonyms (NCBI Gene): BTCD, KIN17, Rts2
• Chromosome: 10
• Chromosome location: 10p14
• Summary: The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its

miRNA Show/Hide all (50)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032026	hsa-miR-16-5p	Proteomics	18668040
MIRT656865	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT656864	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT656862	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT656863	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT656861	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT656860	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT656858	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT656859	hsa-miR-3672	HITS-CLIP	23824327
MIRT656857	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT656865	hsa-miR-128-3p	HITS-CLIP	23824327
MIRT656864	hsa-miR-216a-3p	HITS-CLIP	23824327
MIRT656862	hsa-miR-3681-3p	HITS-CLIP	23824327
MIRT656863	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT656861	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT656860	hsa-miR-873-3p	HITS-CLIP	23824327
MIRT656858	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT656859	hsa-miR-3672	HITS-CLIP	23824327
MIRT656857	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT1095211	hsa-miR-186	CLIP-seq
MIRT1095212	hsa-miR-300	CLIP-seq
MIRT1095213	hsa-miR-323-3p	CLIP-seq
MIRT1095214	hsa-miR-3677-5p	CLIP-seq
MIRT1095215	hsa-miR-381	CLIP-seq
MIRT1095216	hsa-miR-3976	CLIP-seq
MIRT1095217	hsa-miR-4460	CLIP-seq
MIRT1095218	hsa-miR-4666-3p	CLIP-seq
MIRT1095219	hsa-miR-4687-3p	CLIP-seq
MIRT1095220	hsa-miR-4727-3p	CLIP-seq
MIRT1095221	hsa-miR-4729	CLIP-seq
MIRT1095222	hsa-miR-4789-5p	CLIP-seq
MIRT1095223	hsa-miR-548k	CLIP-seq
MIRT1095224	hsa-miR-626	CLIP-seq
MIRT2025560	hsa-miR-198	CLIP-seq
MIRT2025561	hsa-miR-543	CLIP-seq
MIRT2256790	hsa-miR-604	CLIP-seq
MIRT2256791	hsa-miR-647	CLIP-seq
MIRT2558201	hsa-miR-2053	CLIP-seq
MIRT2558202	hsa-miR-3591-3p	CLIP-seq
MIRT2558203	hsa-miR-365	CLIP-seq
MIRT2558204	hsa-miR-3658	CLIP-seq
MIRT2558205	hsa-miR-4312	CLIP-seq
MIRT2558206	hsa-miR-532-5p	CLIP-seq
MIRT2558207	hsa-miR-936	CLIP-seq
MIRT2558202	hsa-miR-3591-3p	CLIP-seq
MIRT2558203	hsa-miR-365	CLIP-seq
MIRT2558204	hsa-miR-3658	CLIP-seq
MIRT2558205	hsa-miR-4312	CLIP-seq
MIRT2558206	hsa-miR-532-5p	CLIP-seq
MIRT2558207	hsa-miR-936	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
XPC	Activation	12525703

Gene ontology (GO) Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	TAS	1923796
GO:0003690	Function	Double-stranded DNA binding	IBA
GO:0003690	Function	Double-stranded DNA binding	IEA
GO:0003690	Function	Double-stranded DNA binding	ISS
GO:0003723	Function	RNA binding	IDA	17045609
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	23349634, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	1923796
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006260	Process	DNA replication	IBA
GO:0006260	Process	DNA replication	IDA	12359749
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006310	Process	DNA recombination	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	17045609
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IEP	12853634
GO:0008270	Function	Zinc ion binding	IEA
GO:0016363	Component	Nuclear matrix	IDA	12754299
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 601720
• HGNC: 6327
• e!Ensembl: ENSG00000151657

Protein

• UniProt ID: O60870
• Protein name: DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein homolog)
• Protein function: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate
• PDB: 2CKK , 2V1N , 7ABH , 7ABI , 8I0P , 9COJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10357	Kin17_mid	52 → 177	Domain of Kin17 curved DNA-binding protein	Family
  PF18131	KN17_SH3	276 → 328	KN17 SH3-like C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined, with highest levels in skeletal muscle, heart and testis. Differentially expressed in non-tumorigenic and tumorigenic cell lines. Highly expressed in proliferating epithelial keratinocyte
• Sequence:

  MGKSDFLTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLLASEN
  PQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTK
  WLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQVRRG
  LEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGATSSKSSTLGPSALKTIGSSASVK
  RKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTARTDYWLQPEIIVKIITKKLGEKYHK
  KKAIVKEVIDKYTAVVKMIDSGDKLKLDQTHLETVIPAPGKRILVLNGGYRGNEGTLESI
  NEKTFSATIVIETGPLKGRRVEGIQYEDISKLA

• Sequence length: 393

Pathways

Reactome Pathway:

Protein methylation

Related Genes

No strongly related genes found yet for KIN.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to KIN.