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Gene Gene information from NCBI Gene database.
Entrez ID 283219
Gene name Potassium channel tetramerization domain containing 21
Gene symbol KCTD21
Synonyms (NCBI Gene)
KCASH2
Chromosome 11
Chromosome location 11q14.1
miRNA miRNA information provided by mirtarbase database.
389 Show/Hide all (389)
miRTarBase ID miRNA Experiments Reference
MIRT517143 hsa-miR-4438 PAR-CLIP 23446348
MIRT517142 hsa-miR-6504-3p PAR-CLIP 23446348
MIRT517141 hsa-miR-759 PAR-CLIP 23446348
MIRT517140 hsa-miR-1234-3p PAR-CLIP 23446348
MIRT517139 hsa-miR-7107-5p PAR-CLIP 23446348
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
12 Show/Hide all (12)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0006511 Process Ubiquitin-dependent protein catabolic process IBA
GO:0006511 Process Ubiquitin-dependent protein catabolic process IDA 21472142
GO:0016567 Process Protein ubiquitination IEA
GO:0042802 Function Identical protein binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618790 27452 ENSG00000188997
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q4G0X4
Protein name BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21)
Protein function Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antago
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02214 BTB_2 5 → 96 BTB/POZ domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. {ECO:0000269|PubMed:21472142}.
Sequence
MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYIL
NFLRTSHLDLPEDFQEMGLLRREADFYQVQPLIEAL
QEKEVELSKAEKNAMLNITLNQRV
QTVHFTVREAPQIYSLSSSSMEVFNANIFSTSCLFLKLLGSKLFYCSNGNLSSITSHLQD
PNHLTLDWVANVEGLPEEEYTKQNLKRLWVVPANKQINSFQVFVEEVLKIALSDGFCIDS
SHPHALDFMNNKIIRLIRYR
Sequence length 260
Interactions View interactions