KCTD21 (potassium channel tetramerization domain containing 21)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 283219 |
| Gene name | Potassium channel tetramerization domain containing 21 |
| Gene symbol | KCTD21 |
| Synonyms (NCBI Gene) |
KCASH2
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| Chromosome | 11 |
| Chromosome location | 11q14.1 |
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miRNA
miRNA information provided by mirtarbase database.
389
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q4G0X4 | ||||||||||
| Protein name | BTB/POZ domain-containing protein KCTD21 (KCASH2 protein) (Potassium channel tetramerization domain-containing protein 21) | ||||||||||
| Protein function | Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antago | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. {ECO:0000269|PubMed:21472142}. | ||||||||||
| Sequence |
MSDPITLNVGGKLYTTSLATLTSFPDSMLGAMFSGKMPTKRDSQGNCFIDRDGKVFRYIL |
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| Sequence length | 260 | ||||||||||
| Interactions | View interactions | ||||||||||
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Related Genes
Genes most often co-reported with KCTD21 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to KCTD21 (see Related Genes above), that are NOT already directly curated for KCTD21 itself -- a lead worth checking, not a confirmed association.
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