KCNK15 (potassium two pore domain channel subfamily K member 15)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 60598
• Gene name: Potassium two pore domain channel subfamily K member 15
• Gene symbol: KCNK15
• Synonyms (NCBI Gene): K2p15.1, KCNK11, KCNK14, KT3.3, TASK-5, TASK5, dJ781B1.1
• Chromosome: 20
• Chromosome location: 20q13.12
• Summary: This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins fo

miRNA Show/Hide all (81)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1081794	hsa-miR-1204	CLIP-seq
MIRT1081795	hsa-miR-1245b-5p	CLIP-seq
MIRT1081796	hsa-miR-1321	CLIP-seq
MIRT1081797	hsa-miR-1324	CLIP-seq
MIRT1081798	hsa-miR-15a	CLIP-seq
MIRT1081799	hsa-miR-15b	CLIP-seq
MIRT1081800	hsa-miR-16	CLIP-seq
MIRT1081801	hsa-miR-195	CLIP-seq
MIRT1081802	hsa-miR-298	CLIP-seq
MIRT1081803	hsa-miR-3065-3p	CLIP-seq
MIRT1081804	hsa-miR-3142	CLIP-seq
MIRT1081805	hsa-miR-3173-3p	CLIP-seq
MIRT1081806	hsa-miR-3978	CLIP-seq
MIRT1081807	hsa-miR-424	CLIP-seq
MIRT1081808	hsa-miR-432	CLIP-seq
MIRT1081809	hsa-miR-4419a	CLIP-seq
MIRT1081810	hsa-miR-4510	CLIP-seq
MIRT1081811	hsa-miR-4632	CLIP-seq
MIRT1081812	hsa-miR-4645-3p	CLIP-seq
MIRT1081813	hsa-miR-4650-5p	CLIP-seq
MIRT1081814	hsa-miR-4652-5p	CLIP-seq
MIRT1081815	hsa-miR-4662a-5p	CLIP-seq
MIRT1081816	hsa-miR-4728-5p	CLIP-seq
MIRT1081817	hsa-miR-4738-3p	CLIP-seq
MIRT1081818	hsa-miR-4739	CLIP-seq
MIRT1081819	hsa-miR-4756-5p	CLIP-seq
MIRT1081820	hsa-miR-4779	CLIP-seq
MIRT1081821	hsa-miR-4786-3p	CLIP-seq
MIRT1081822	hsa-miR-497	CLIP-seq
MIRT1081823	hsa-miR-516b	CLIP-seq
MIRT1081824	hsa-miR-539	CLIP-seq
MIRT1081825	hsa-miR-759	CLIP-seq
MIRT1081796	hsa-miR-1321	CLIP-seq
MIRT1081797	hsa-miR-1324	CLIP-seq
MIRT2020260	hsa-miR-1468	CLIP-seq
MIRT2020261	hsa-miR-1914	CLIP-seq
MIRT2020262	hsa-miR-2467-3p	CLIP-seq
MIRT2020263	hsa-miR-302a	CLIP-seq
MIRT2020264	hsa-miR-302b	CLIP-seq
MIRT2020265	hsa-miR-302c	CLIP-seq
MIRT2020266	hsa-miR-302d	CLIP-seq
MIRT2020267	hsa-miR-302e	CLIP-seq
MIRT2020268	hsa-miR-3153	CLIP-seq
MIRT2020269	hsa-miR-3192	CLIP-seq
MIRT2020270	hsa-miR-3670	CLIP-seq
MIRT2020271	hsa-miR-3678-3p	CLIP-seq
MIRT2020272	hsa-miR-372	CLIP-seq
MIRT2020273	hsa-miR-373	CLIP-seq
MIRT2020274	hsa-miR-3944-5p	CLIP-seq
MIRT2020275	hsa-miR-3974	CLIP-seq
MIRT2020276	hsa-miR-4314	CLIP-seq
MIRT1081809	hsa-miR-4419a	CLIP-seq
MIRT1081810	hsa-miR-4510	CLIP-seq
MIRT2020277	hsa-miR-4535	CLIP-seq
MIRT1081812	hsa-miR-4645-3p	CLIP-seq
MIRT1081814	hsa-miR-4652-5p	CLIP-seq
MIRT1081815	hsa-miR-4662a-5p	CLIP-seq
MIRT2020278	hsa-miR-4667-5p	CLIP-seq
MIRT2020279	hsa-miR-4700-5p	CLIP-seq
MIRT2020280	hsa-miR-4725-5p	CLIP-seq
MIRT1081816	hsa-miR-4728-5p	CLIP-seq
MIRT1081818	hsa-miR-4739	CLIP-seq
MIRT2020281	hsa-miR-4747-3p	CLIP-seq
MIRT1081819	hsa-miR-4756-5p	CLIP-seq
MIRT2020282	hsa-miR-4800-5p	CLIP-seq
MIRT2020283	hsa-miR-492	CLIP-seq
MIRT2020284	hsa-miR-504	CLIP-seq
MIRT2020285	hsa-miR-512-3p	CLIP-seq
MIRT2020286	hsa-miR-519a	CLIP-seq
MIRT2020287	hsa-miR-519b-3p	CLIP-seq
MIRT2020288	hsa-miR-519c-3p	CLIP-seq
MIRT2020289	hsa-miR-520a-3p	CLIP-seq
MIRT2020290	hsa-miR-520b	CLIP-seq
MIRT2020291	hsa-miR-520c-3p	CLIP-seq
MIRT2020292	hsa-miR-520d-3p	CLIP-seq
MIRT2020293	hsa-miR-520e	CLIP-seq
MIRT2020294	hsa-miR-583	CLIP-seq
MIRT2020295	hsa-miR-615-3p	CLIP-seq
MIRT2020296	hsa-miR-637	CLIP-seq
MIRT2252092	hsa-miR-663b	CLIP-seq
MIRT1081816	hsa-miR-4728-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005244	Function	Voltage-gated monoatomic ion channel activity	IDA	11749039
GO:0005267	Function	Potassium channel activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0022841	Function	Potassium ion leak channel activity	IBA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0071468	Process	Cellular response to acidic pH	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:0071805	Process	Potassium ion transmembrane transport	IEA

Other IDs

• MIM: 607368
• HGNC: 13814
• e!Ensembl: ENSG00000124249

Protein

• UniProt ID: Q9H427
• Protein name: Potassium channel subfamily K member 15 (Acid-sensitive potassium channel protein TASK-5) (TWIK-related acid-sensitive K(+) channel 5) (Two pore potassium channel KT3.3) (Two pore K(+) channel KT3.3)
• Protein function: Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional channel.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07885	Ion_trans_2	60 → 134	Ion channel	Family
  PF07885	Ion_trans_2	165 → 248	Ion channel	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in pancreas, heart, placenta, lung, liver, kidney, ovary, testis, skeletal muscle and adrenal gland, and at lower levels in prostate, spleen and thyroid gland. {ECO:0000269|PubMed:11409881, ECO:0000269|PubMed:11680614}.
• Sequence:

  MRRPSVRAAGLVLCTLCYLLVGAAVFDALESEAESGRQRLLVQKRGALRRKFGFSAEDYR
  ELERLALQAEPHRAGRQWKFPGSFYFAITVITTIGYGHAAPGTDSGKVFCMFYALLGIPL
  TLVTFQSLGERLNAVVRRLLLAAKCCLGLRWTCVSTENLVVAGLLACAATLALGAVAFSH
  FEGWTFFHAYYYCFITLTTIGFGDFVALQSGEALQRKLPYVAFSFLYILLGLTVIGAFLN
  LVVLRFLVASADWPERAARPPSPRPPGAPESRGLWLPRRPARSVGSASVFCHVHKLERCA
  RDNLGFSPPSSPGVVRGGQAPRPGARWKSI

• Sequence length: 330

Pathways

Reactome Pathway:

Phase 4 - resting membrane potential

Related Genes

No strongly related genes found yet for KCNK15.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to KCNK15.