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Gene Gene information from NCBI Gene database.
Entrez ID 89890
Gene name Kelch repeat and BTB domain containing 6
Gene symbol KBTBD6
Synonyms (NCBI Gene)
-
Chromosome 13
Chromosome location 13q14.11
miRNA miRNA information provided by mirtarbase database.
1159 Show/Hide all (1159)
miRTarBase ID miRNA Experiments Reference
MIRT023414 hsa-miR-30b-5p Sequencing 20371350
MIRT025495 hsa-miR-34a-5p Sequencing 20371350
MIRT030933 hsa-miR-21-5p Microarray 18591254
MIRT047472 hsa-miR-10b-5p CLASH 23622248
MIRT709637 hsa-miR-519a-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20562859, 21145461, 25684205, 26496610, 28514442, 30190310, 33961781, 34591642
GO:0005634 Component Nucleus IDA 25684205
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 25684205
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617738 25340 ENSG00000165572
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86V97
Protein name Kelch repeat and BTB domain-containing protein 6
Protein function As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this
PDB 4XC2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 53 → 168 BTB/POZ domain Domain
PF01344 Kelch_1 424 → 471 Kelch motif Repeat
PF07707 BACK 173 → 277 BTB And C-terminal Kelch Domain
Sequence
MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDAR
LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE
SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRL
DLTNCTAILKFA
DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC
HVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDY
LEGLLTKPIVKKYCLDVIEGALQ
MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCD
PYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLAD
RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLM
VIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPV
RAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGT
TLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSS
SLSDDDFWVRVAPQ
Sequence length 674
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation