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Gene Gene information from NCBI Gene database.
Entrez ID 25948
Gene name Kelch repeat and BTB domain containing 2
Gene symbol KBTBD2
Synonyms (NCBI Gene)
BKLHD1
Chromosome 7
Chromosome location 7p14.3
miRNA miRNA information provided by mirtarbase database.
494 Show/Hide all (494)
miRTarBase ID miRNA Experiments Reference
MIRT005097 hsa-miR-155-5p Microarray 19193853
MIRT005097 hsa-miR-155-5p Microarray 19193853
MIRT019503 hsa-miR-151a-3p Sequencing 20371350
MIRT020285 hsa-miR-130b-3p Sequencing 20371350
MIRT005097 hsa-miR-155-5p Reporter assay;Other 20584899
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 27708159
GO:0006006 Process Glucose metabolic process IEA
GO:0006629 Process Lipid metabolic process IEA
GO:0010467 Process Gene expression IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619393 21751 ENSG00000170852
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8IY47
Protein name Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1)
Protein function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the re
PDB 8GQ6 , 8H33 , 8H34 , 8H35 , 8H36 , 8H37 , 8H38 , 8H3A , 8H3F , 8H3R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 21 → 128 BTB/POZ domain Domain
PF01344 Kelch_1 370 → 416 Kelch motif Repeat
PF07707 BACK 133 → 232 BTB And C-terminal Kelch Domain
Sequence
MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMF
MSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRC
REYLIKKI
NAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDI
LSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRA
WFQGLPPN
DKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCS
PPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTW
FPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQ
WSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIA
TNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRE
THLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPT
YLFSTDGTEEFELDGEMVALPPV
Sequence length 623
Interactions View interactions