Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	83473
Gene name	Katanin catalytic subunit A1 like 2
Gene symbol	KATNAL2
Synonyms (NCBI Gene)	-
Chromosome	18
Chromosome location	18q21.1

36 Show/Hide all (36)

miRTarBase ID	miRNA	Experiments
MIRT1079191	hsa-miR-1206	CLIP-seq
MIRT1079192	hsa-miR-1207-3p	CLIP-seq
MIRT1079193	hsa-miR-1276	CLIP-seq
MIRT1079194	hsa-miR-1285	CLIP-seq
MIRT1079195	hsa-miR-1289	CLIP-seq
MIRT1079196	hsa-miR-203	CLIP-seq
MIRT1079197	hsa-miR-3154	CLIP-seq
MIRT1079198	hsa-miR-3187-5p	CLIP-seq
MIRT1079199	hsa-miR-3198	CLIP-seq
MIRT1079200	hsa-miR-34a	CLIP-seq
MIRT1079201	hsa-miR-34c-5p	CLIP-seq
MIRT1079202	hsa-miR-3647-3p	CLIP-seq
MIRT1079203	hsa-miR-3688-3p	CLIP-seq
MIRT1079204	hsa-miR-3978	CLIP-seq
MIRT1079205	hsa-miR-4282	CLIP-seq
MIRT1079206	hsa-miR-4294	CLIP-seq
MIRT1079207	hsa-miR-4309	CLIP-seq
MIRT1079208	hsa-miR-4311	CLIP-seq
MIRT1079209	hsa-miR-4435	CLIP-seq
MIRT1079210	hsa-miR-4436b-3p	CLIP-seq
MIRT1079211	hsa-miR-4474-3p	CLIP-seq
MIRT1079212	hsa-miR-449a	CLIP-seq
MIRT1079213	hsa-miR-449b	CLIP-seq
MIRT1079214	hsa-miR-4735-5p	CLIP-seq
MIRT1079215	hsa-miR-4802-5p	CLIP-seq
MIRT1079216	hsa-miR-515-3p	CLIP-seq
MIRT1079217	hsa-miR-519e	CLIP-seq
MIRT1079218	hsa-miR-548c-3p	CLIP-seq
MIRT1079219	hsa-miR-550a	CLIP-seq
MIRT1079220	hsa-miR-583	CLIP-seq
MIRT1079221	hsa-miR-587	CLIP-seq
MIRT1079222	hsa-miR-590-3p	CLIP-seq
MIRT1079223	hsa-miR-612	CLIP-seq
MIRT1079224	hsa-miR-663b	CLIP-seq
MIRT2251638	hsa-miR-4775	CLIP-seq
MIRT1079222	hsa-miR-590-3p	CLIP-seq

25 Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000212	Process	Meiotic spindle organization	IBA
GO:0000922	Component	Spindle pole	IDA	26929214
GO:0000922	Component	Spindle pole	IEA
GO:0005515	Function	Protein binding	IPI	25910212, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	26929214
GO:0005737	Component	Cytoplasm	IEA
GO:0005819	Component	Spindle	IBA
GO:0005819	Component	Spindle	IDA	26929214
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IDA	26929214
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0008352	Component	Katanin complex	ISS
GO:0008568	Function	Microtubule severing ATPase activity	IEA
GO:0015630	Component	Microtubule cytoskeleton	NAS	28436967
GO:0016853	Function	Isomerase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0031122	Process	Cytoplasmic microtubule organization	NAS	28436967
GO:0051013	Process	Microtubule severing	IBA
GO:0051013	Process	Microtubule severing	IEA

MIM	HGNC	e!Ensembl
614697	25387	ENSG00000167216

Q8IYT4

Protein name

Katanin p60 ATPase-containing subunit A-like 2 (Katanin p60 subunit A-like 2) (EC 5.6.1.1) (p60 katanin-like 2)

Protein function

Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00004	AAA	290 → 422	ATPase family associated with various cellular activities (AAA)	Domain
PF08513	LisH	27 → 53	LisH	Domain
PF17862	AAA_lid_3	450 → 497	AAA+ lid domain	Domain

Sequence

MELSYQTLKFTHQAREACEMRTEARRKNLLILISHYLTQEGYIDTANALEQETKLGLRRF
EVCDNIDLETILMEYESYYFVKFQKYPKIVKKSSDTAENNLPQRSRGKTRRMMNDSCQNL
PKINQQRPRSKTTAGKTGDTKSLNKEHPNQEVVDNTRLESANFGLHISRIRKDSGEENAH
PRRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVV
SRDIYLHNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGILSPWKGLLLYGPPGTGK
TLLAKAVATECKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMS
QRGTASGGEHEGSLRMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLRRLEKRILV
DLPSREARQAMIYHWLPPVSKSRALELHTELEYSVLSQETEGYSGSDIKLVCREAAMRPV
RKIFDALENHQSESSDLPRIQLDIVTTADFLDVLTHTKPSAKNLAQRYSDWQREFESV

Sequence length

538

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal. Show/Hide Unknown Diseases (17)
Acute myeloid leukemia	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	34743297	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	37359372	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COMPLEX NEURODEVELOPMENTAL DISORDER	—	ClinGen	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	39046104	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KATNAL2-related autism	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KATNAL2-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	CTD, Disgenet CTD, Disgenet	28191889	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	31374203	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (10)
Autism Spectrum Disorder	Autism	Pubtator	22495311	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	30096282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	BEFREE	22495311, 30096282		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	22495311	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	23018867	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	33482905	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mouth Diseases	Mouth disease	Pubtator	23018867	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	CTD_human_DG	28191889		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Restless Legs Syndrome	Willis-ekbom disease	Pubtator	22929029	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

KATNAL2 (katanin catalytic subunit A1 like 2)

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