JTB (jumping translocation breakpoint)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10899
• Gene name: Jumping translocation breakpoint
• Gene symbol: JTB
• Synonyms (NCBI Gene): HJTB, HSPC222, PAR, hJT
• Chromosome: 1
• Chromosome location: 1q21.3

miRNA Show/Hide all (86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048073	hsa-miR-197-3p	CLASH	23622248
MIRT046770	hsa-miR-222-3p	CLASH	23622248
MIRT1077985	hsa-miR-1	CLIP-seq
MIRT1077986	hsa-miR-1182	CLIP-seq
MIRT1077987	hsa-miR-1208	CLIP-seq
MIRT1077988	hsa-miR-130a	CLIP-seq
MIRT1077989	hsa-miR-130b	CLIP-seq
MIRT1077990	hsa-miR-1910	CLIP-seq
MIRT1077991	hsa-miR-19a	CLIP-seq
MIRT1077992	hsa-miR-19b	CLIP-seq
MIRT1077993	hsa-miR-2052	CLIP-seq
MIRT1077994	hsa-miR-206	CLIP-seq
MIRT1077995	hsa-miR-2110	CLIP-seq
MIRT1077996	hsa-miR-300	CLIP-seq
MIRT1077997	hsa-miR-301a	CLIP-seq
MIRT1077998	hsa-miR-301b	CLIP-seq
MIRT1077999	hsa-miR-3120-5p	CLIP-seq
MIRT1078000	hsa-miR-3133	CLIP-seq
MIRT1078001	hsa-miR-3184	CLIP-seq
MIRT1078002	hsa-miR-3666	CLIP-seq
MIRT1078003	hsa-miR-3667-5p	CLIP-seq
MIRT1078004	hsa-miR-3673	CLIP-seq
MIRT1078005	hsa-miR-381	CLIP-seq
MIRT1078006	hsa-miR-423-5p	CLIP-seq
MIRT1078007	hsa-miR-4251	CLIP-seq
MIRT1078008	hsa-miR-4271	CLIP-seq
MIRT1078009	hsa-miR-4295	CLIP-seq
MIRT1078010	hsa-miR-4329	CLIP-seq
MIRT1078011	hsa-miR-4420	CLIP-seq
MIRT1078012	hsa-miR-4434	CLIP-seq
MIRT1078013	hsa-miR-4450	CLIP-seq
MIRT1078014	hsa-miR-4457	CLIP-seq
MIRT1078015	hsa-miR-4516	CLIP-seq
MIRT1078016	hsa-miR-454	CLIP-seq
MIRT1078017	hsa-miR-455-3p	CLIP-seq
MIRT1078018	hsa-miR-4658	CLIP-seq
MIRT1078019	hsa-miR-4725-3p	CLIP-seq
MIRT1078020	hsa-miR-4758-5p	CLIP-seq
MIRT1078021	hsa-miR-4765	CLIP-seq
MIRT1078022	hsa-miR-4795-5p	CLIP-seq
MIRT1078023	hsa-miR-491-5p	CLIP-seq
MIRT1078024	hsa-miR-539	CLIP-seq
MIRT1078025	hsa-miR-541	CLIP-seq
MIRT1078026	hsa-miR-548b-3p	CLIP-seq
MIRT1078027	hsa-miR-613	CLIP-seq
MIRT1078028	hsa-miR-624	CLIP-seq
MIRT1078029	hsa-miR-654-5p	CLIP-seq
MIRT1078030	hsa-miR-7	CLIP-seq
MIRT1077987	hsa-miR-1208	CLIP-seq
MIRT1077999	hsa-miR-3120-5p	CLIP-seq
MIRT1078007	hsa-miR-4251	CLIP-seq
MIRT1078010	hsa-miR-4329	CLIP-seq
MIRT1078011	hsa-miR-4420	CLIP-seq
MIRT1077986	hsa-miR-1182	CLIP-seq
MIRT1077987	hsa-miR-1208	CLIP-seq
MIRT1077990	hsa-miR-1910	CLIP-seq
MIRT1077995	hsa-miR-2110	CLIP-seq
MIRT1077999	hsa-miR-3120-5p	CLIP-seq
MIRT2251233	hsa-miR-3529	CLIP-seq
MIRT1078003	hsa-miR-3667-5p	CLIP-seq
MIRT2251234	hsa-miR-379	CLIP-seq
MIRT1078007	hsa-miR-4251	CLIP-seq
MIRT2251235	hsa-miR-4260	CLIP-seq
MIRT1078008	hsa-miR-4271	CLIP-seq
MIRT1078010	hsa-miR-4329	CLIP-seq
MIRT1078011	hsa-miR-4420	CLIP-seq
MIRT1078012	hsa-miR-4434	CLIP-seq
MIRT2251236	hsa-miR-4451	CLIP-seq
MIRT1078015	hsa-miR-4516	CLIP-seq
MIRT1078017	hsa-miR-455-3p	CLIP-seq
MIRT2251237	hsa-miR-4650-3p	CLIP-seq
MIRT2251238	hsa-miR-4668-5p	CLIP-seq
MIRT2251239	hsa-miR-4716-3p	CLIP-seq
MIRT1078019	hsa-miR-4725-3p	CLIP-seq
MIRT1078022	hsa-miR-4795-5p	CLIP-seq
MIRT1078023	hsa-miR-491-5p	CLIP-seq
MIRT1078025	hsa-miR-541	CLIP-seq
MIRT2251240	hsa-miR-570	CLIP-seq
MIRT2251241	hsa-miR-625	CLIP-seq
MIRT1078029	hsa-miR-654-5p	CLIP-seq
MIRT1078030	hsa-miR-7	CLIP-seq
MIRT1077986	hsa-miR-1182	CLIP-seq
MIRT1077987	hsa-miR-1208	CLIP-seq
MIRT1077999	hsa-miR-3120-5p	CLIP-seq
MIRT1078007	hsa-miR-4251	CLIP-seq
MIRT1078010	hsa-miR-4329	CLIP-seq

Gene ontology (GO) Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IMP	21225229
GO:0000281	Process	Mitotic cytokinesis	IBA
GO:0000281	Process	Mitotic cytokinesis	IMP	21225229
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	21225229
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	21225229
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IBA
GO:0005819	Component	Spindle	IDA	21225229
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	TAS	10321732
GO:0006915	Process	Apoptotic process	IEA
GO:0008637	Process	Apoptotic mitochondrial changes	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10321732
GO:0019901	Function	Protein kinase binding	IDA	21225229
GO:0030496	Component	Midbody	IBA
GO:0030496	Component	Midbody	IDA	21225229
GO:0042127	Process	Regulation of cell population proliferation	IEA
GO:0045860	Process	Positive regulation of protein kinase activity	IMP	21225229
GO:0051301	Process	Cell division	IEA

Other IDs

• MIM: 604671
• HGNC: 6201
• e!Ensembl: ENSG00000143543

Protein

• UniProt ID: O76095
• Protein name: Protein JTB (Jumping translocation breakpoint protein) (Prostate androgen-regulated protein) (PAR protein)
• Protein function: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential
• PDB: 2KJX
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05439	JTB	37 → 143	Jumping translocation breakpoint protein (JTB)	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. {ECO:0000269|PubMed:10321732, ECO:0000269|PubMed:10762645, ECO:0000269|PubMed:17369841, ECO:0000269|
• Sequence:

  MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEEC
  SPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIF
  ACLVIIRQRQLDRKALEKVRKQIESI

• Sequence length: 146

Related Genes

No strongly related genes found yet for JTB.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to JTB.