JOSD2 (Josephin domain containing 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 126119
• Gene name: Josephin domain containing 2
• Gene symbol: JOSD2
• Synonyms (NCBI Gene): SBBI54
• Chromosome: 19
• Chromosome location: 19q13.33
• Summary: This gene encodes a protein containing a Josephin domain. Josephin domain-containing proteins are deubiquitinating enzymes which catalyze the hydrolysis of the bond between the C-terminal glycine of the ubiquitin peptide and protein substrates. Alternativ

miRNA Show/Hide all (41)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1077455	hsa-miR-1908	CLIP-seq
MIRT1077456	hsa-miR-1909	CLIP-seq
MIRT1077457	hsa-miR-3150a-3p	CLIP-seq
MIRT1077458	hsa-miR-3151	CLIP-seq
MIRT1077459	hsa-miR-3175	CLIP-seq
MIRT1077460	hsa-miR-3180	CLIP-seq
MIRT1077461	hsa-miR-3180-3p	CLIP-seq
MIRT1077462	hsa-miR-3196	CLIP-seq
MIRT1077463	hsa-miR-4447	CLIP-seq
MIRT1077464	hsa-miR-4455	CLIP-seq
MIRT1077465	hsa-miR-4472	CLIP-seq
MIRT1077466	hsa-miR-4488	CLIP-seq
MIRT1077467	hsa-miR-4697-5p	CLIP-seq
MIRT1077468	hsa-miR-4728-5p	CLIP-seq
MIRT1077469	hsa-miR-491-5p	CLIP-seq
MIRT1077470	hsa-miR-663	CLIP-seq
MIRT1077471	hsa-miR-744	CLIP-seq
MIRT1077472	hsa-miR-939	CLIP-seq
MIRT2019225	hsa-miR-1915	CLIP-seq
MIRT2019226	hsa-miR-302a	CLIP-seq
MIRT2019227	hsa-miR-302b	CLIP-seq
MIRT2019228	hsa-miR-302c	CLIP-seq
MIRT2019229	hsa-miR-302d	CLIP-seq
MIRT2019230	hsa-miR-302e	CLIP-seq
MIRT2019231	hsa-miR-3176	CLIP-seq
MIRT2019232	hsa-miR-3616-5p	CLIP-seq
MIRT2019233	hsa-miR-3647-5p	CLIP-seq
MIRT2019234	hsa-miR-372	CLIP-seq
MIRT2019235	hsa-miR-373	CLIP-seq
MIRT2019236	hsa-miR-3922-3p	CLIP-seq
MIRT2019237	hsa-miR-4645-5p	CLIP-seq
MIRT2019238	hsa-miR-4673	CLIP-seq
MIRT2019239	hsa-miR-4726-3p	CLIP-seq
MIRT2019240	hsa-miR-4795-5p	CLIP-seq
MIRT2019241	hsa-miR-512-3p	CLIP-seq
MIRT2019242	hsa-miR-520a-3p	CLIP-seq
MIRT2019243	hsa-miR-520b	CLIP-seq
MIRT2019244	hsa-miR-520c-3p	CLIP-seq
MIRT2019245	hsa-miR-520d-3p	CLIP-seq
MIRT2019246	hsa-miR-520e	CLIP-seq
MIRT2019247	hsa-miR-573	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IBA
GO:0004843	Function	Cysteine-type deubiquitinase activity	IDA	21118805
GO:0004843	Function	Cysteine-type deubiquitinase activity	IEA
GO:0004843	Function	Cysteine-type deubiquitinase activity	TAS
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0016579	Process	Protein deubiquitination	IDA	21118805
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016579	Process	Protein deubiquitination	IEA
GO:0016579	Process	Protein deubiquitination	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0101005	Function	Deubiquitinase activity	IEA

Other IDs

• MIM: 615324
• HGNC: 28853
• e!Ensembl: ENSG00000161677

Protein

• UniProt ID: Q8TAC2
• Protein name: Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2)
• Protein function: Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. {ECO:0000269|PubMed:17696782, ECO:0000269|PubMed:21118805, ECO:0000269|PubMed:23625
• PDB: 6PGV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02099	Josephin	19 → 174	Josephin	Family

• Sequence:

  MSQAPGAQPSPPTVYHERQRLELCAVHALNNVLQQQLFSQEAADEICKRLAPDSRLNPHR
  SLLGTGNYDVNVIMAALQGLGLAAVWWDRRRPLSQLALPQVLGLILNLPSPVSLGLLSLP
  LRRRHWVALRQVDGVYYNLDSKLRAPEALGDEDGVRAFLAAALAQGLCEVLLVVTKEVEE
  KGSWLRTD

• Sequence length: 188

Pathways

Reactome Pathway:

Josephin domain DUBs

Related Genes

No strongly related genes found yet for JOSD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to JOSD2.