JADE1 (jade family PHD finger 1)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79960
• Gene name: Jade family PHD finger 1
• Gene symbol: JADE1
• Synonyms (NCBI Gene): PHF17
• Chromosome: 4
• Chromosome location: 4q28.2

miRNA Show/Hide all (22)

miRTarBase ID	miRNA	Experiments	Reference
MIRT093074	hsa-miR-6854-5p	PAR-CLIP	22012620
MIRT093069	hsa-miR-4427	PAR-CLIP	22012620
MIRT093073	hsa-miR-5187-3p	PAR-CLIP	22012620
MIRT093071	hsa-miR-4680-3p	PAR-CLIP	22012620
MIRT093070	hsa-miR-219b-3p	PAR-CLIP	22012620
MIRT535297	hsa-miR-219a-2-3p	PAR-CLIP	22012620
MIRT093068	hsa-miR-3934-3p	PAR-CLIP	22012620
MIRT535296	hsa-miR-8068	PAR-CLIP	22012620
MIRT093072	hsa-miR-5010-3p	PAR-CLIP	22012620
MIRT001806	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT001806	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT093074	hsa-miR-6854-5p	PAR-CLIP	22012620
MIRT093069	hsa-miR-4427	PAR-CLIP	22012620
MIRT093073	hsa-miR-5187-3p	PAR-CLIP	22012620
MIRT093071	hsa-miR-4680-3p	PAR-CLIP	22012620
MIRT093070	hsa-miR-219b-3p	PAR-CLIP	22012620
MIRT754442	hsa-miR-219a-2-3p	PAR-CLIP	22012620
MIRT093068	hsa-miR-3934-3p	PAR-CLIP	22012620
MIRT754443	hsa-miR-8068	PAR-CLIP	22012620
MIRT093072	hsa-miR-5010-3p	PAR-CLIP	22012620
MIRT093071	hsa-miR-4680-3p	Western blotting, qRT-PCR	38191190
MIRT756235	hsa-miR-155-5p	Luciferase reporter assay, qRT-PCR	37175531

Gene ontology (GO) Show/Hide all (43)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000123	Component	Histone acetyltransferase complex	IBA
GO:0000123	Component	Histone acetyltransferase complex	IDA	16387653
GO:0000123	Component	Histone acetyltransferase complex	IEA
GO:0000123	Component	Histone acetyltransferase complex	IPI	16387653
GO:0001558	Process	Regulation of cell growth	IDA	22144582
GO:0003713	Function	Transcription coactivator activity	IDA	23001567
GO:0005515	Function	Protein binding	IPI	12169691, 22654112, 24981860, 25416956, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	12169691, 24739512
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	16387653
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IDA	12169691
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA	24739512
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	23001567
GO:0006275	Process	Regulation of DNA replication	IDA	16387653
GO:0006275	Process	Regulation of DNA replication	IEA
GO:0006338	Process	Chromatin remodeling	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IDA	22144582
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006915	Process	Apoptotic process	IEA
GO:0006915	Process	Apoptotic process	NAS	12169691
GO:0008270	Function	Zinc ion binding	IEA
GO:0016607	Component	Nuclear speck	IDA	12169691
GO:0030308	Process	Negative regulation of cell growth	NAS	12169691
GO:0036064	Component	Ciliary basal body	IDA	22654112
GO:0036408	Function	Histone H3K14 acetyltransferase activity	IDA	16387653
GO:0042995	Component	Cell projection	IEA
GO:0043995	Function	Histone H4K5 acetyltransferase activity	IDA	16387653
GO:0043996	Function	Histone H4K8 acetyltransferase activity	IDA	16387653
GO:0043997	Function	Histone H4K12 acetyltransferase activity	IDA	16387653
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046972	Function	Histone H4K16 acetyltransferase activity	IDA	16387653
GO:0051726	Process	Regulation of cell cycle	IDA	16387653
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	22654112
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	23001567
GO:2000278	Process	Regulation of DNA biosynthetic process	IDA	16387653
GO:2000278	Process	Regulation of DNA biosynthetic process	IEA

Other IDs

• MIM: 610514
• HGNC: 30027
• e!Ensembl: ENSG00000077684

Protein

• UniProt ID: Q6IE81
• Protein name: Protein Jade-1 (Jade family PHD finger protein 1) (PHD finger protein 17)
• Protein function: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone
• PDB: 8GDX , 8GE0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10513	EPL1	4 → 181	Enhancer of polycomb-like	Family
  PF13831	PHD_2	217 → 251		Family
  PF13832	zf-HC5HC2H_2	256 → 368		Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. {ECO:0000269|PubMed:12169691, ECO:0000269|PubMed:16046545}.
• Sequence:

  MKRGRLPSSSEDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHD
  SYQLNPDEYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIVSSG
  SEPPELGYVDIRTLADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQ
  RCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKV
  PEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPI
  TKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVK
  FKSYCPKHSSHRKPEESLGKGAAQENGAPECSPRNPLEPFASLEQNREEAHRVSVRKQKL
  QQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKVNFNKPLITPKKDEEDNLAKR
  EQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFNLYTKLLEQERVS
  GVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQMGTSLVHSLKKPHKRDPL
  QNSPGSEGKTLLKQPDLCGRREGMVVPESFLGLEKTFAEARLISAQQKNGVVMPDHGKRR
  DNRFHCDLIKGDLKDKSFKQSHKPLRSTDVSQRHLDNTRAATSPGVGQSAPGTRKEIVPK
  CNGSLIKVNYNQTAVKVPTTPASPVKNWGGFRIPKKGERQQQGEAHDGACHQHSDYPYLG
  LGRVPAKERAKSKLKSDNENDGYVPDVEMSDSESEASEKKCIHTSSTISRRTDIIRRSIL
  AS

• Sequence length: 842

Pathways

Reactome Pathway:

HATs acetylate histones

Related Genes

No strongly related genes found yet for JADE1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to JADE1.