ITPRIPL1 (ITPRIP like 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 150771 |
| Gene name | ITPRIP like 1 |
| Gene symbol | ITPRIPL1 |
| Synonyms (NCBI Gene) |
D1BKIAA1754L
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| Chromosome | 2 |
| Chromosome location | 2q11.2 |
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miRNA
miRNA information provided by mirtarbase database.
279
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6GPH6 | ||||||||||
| Protein name | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 | ||||||||||
| Protein function | Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-N | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in testis and tumoral cells. {ECO:0000269|PubMed:38614099}. | ||||||||||
| Sequence |
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| Sequence length | 555 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ITPRIPL1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ITPRIPL1 (see Related Genes above), that are NOT already directly curated for ITPRIPL1 itself -- a lead worth checking, not a confirmed association.
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