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Gene Gene information from NCBI Gene database.
Entrez ID 150771
Gene name ITPRIP like 1
Gene symbol ITPRIPL1
Synonyms (NCBI Gene)
D1BKIAA1754L
Chromosome 2
Chromosome location 2q11.2
miRNA miRNA information provided by mirtarbase database.
279 Show/Hide all (279)
miRTarBase ID miRNA Experiments Reference
MIRT508369 hsa-miR-590-3p HITS-CLIP 21572407
MIRT508368 hsa-miR-410-3p HITS-CLIP 21572407
MIRT508367 hsa-miR-5011-5p HITS-CLIP 21572407
MIRT508366 hsa-miR-4775 HITS-CLIP 21572407
MIRT508365 hsa-miR-190a-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 32296183
GO:0005886 Component Plasma membrane IDA 38614099
GO:0005886 Component Plasma membrane IEA
GO:0007165 Process Signal transduction IEA
GO:0009968 Process Negative regulation of signal transduction IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
620821 29371 ENSG00000198885
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6GPH6
Protein name Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1
Protein function Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-N
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03281 Mab-21 235 → 537 Mab-21 protein Family
Tissue specificity TISSUE SPECIFICITY: Expressed in testis and tumoral cells. {ECO:0000269|PubMed:38614099}.
Sequence
MNVDAEASMAVISLLFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRLLEMEFE
ERKRAAEQRQKAENFWTGDTSSDQLVLGKKDMGWPFQADGQEGPLGWMLGNLWNTGLFCL
FLVFELLRQNMQHEPAFDSSSEEEEEEVRVVPVTSYNWLTDFPSQEALDSFYKHYVQNAI
RDLPCTCEFVESFVDDLIEACRVLSRQEAHPQLEDCLGIGAAFEKWGTLHETQKFDILVP
IVPPQGTMFVLEMRDPALGRRCGCVLVESECVCKREKLLGDVLCLVHHHRDPSAVLGKCS
SSIKAALCTGFHLDVCKTVQWFRNMMGNAWALVAHKYDFKLSLPPSTTSCKLRLDYRSGR
FLSIHLVLGVQREDTLVYLVSQAPDQEQLTSVDWPESFVACEHLFLKLVGRFAPENTCHL
KCLQIILSLRQHQSLPHGASRPILTSYHFKTALMHLLLRLPLTDWAHNMLSQRLQDILWF
LGRGLQQRSLHHFLIGNNFLPLTIPIPKTFRNAEPVNLFQHLVLNPKAHSQAVEEFQ
NLL
TQVKTLPHAPLAAAP
Sequence length 555
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Prostate cancer Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 31558162
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 37628841 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only