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Gene Gene information from NCBI Gene database.
Entrez ID 81618
Gene name Integral membrane protein 2C
Gene symbol ITM2C
Synonyms (NCBI Gene)
BRI3BRICD2CE25E25CITM3
Chromosome 2
Chromosome location 2q37.1
miRNA miRNA information provided by mirtarbase database.
510 Show/Hide all (510)
miRTarBase ID miRNA Experiments Reference
MIRT027070 hsa-miR-103a-3p Sequencing 20371350
MIRT043113 hsa-miR-324-5p CLASH 23622248
MIRT040849 hsa-miR-18a-3p CLASH 23622248
MIRT036807 hsa-miR-877-3p CLASH 23622248
MIRT517536 hsa-miR-548az-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IBA
GO:0001540 Function Amyloid-beta binding IPI 19849849
GO:0005515 Function Protein binding IPI 18452648, 19366692, 32296183
GO:0005524 Function ATP binding IEA
GO:0005764 Component Lysosome IDA 14592447
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609554 6175 ENSG00000135916
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NQX7
Protein name Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]
Protein function Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04089 BRICHOS 138 → 229 BRICHOS domain Domain
Tissue specificity TISSUE SPECIFICITY: High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. {ECO:0000269|PubMed:11290423, ECO:00
Sequence
MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPAREEQPPQHRSKRGGSVGGVCY
LSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKI
YLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFW
ELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYR
LRRRATRRRIN
KRGAKNCNAIRHFENTFVVETLICGVV
Sequence length 267
Interactions View interactions