ITM2A (integral membrane protein 2A)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9452
• Gene name: Integral membrane protein 2A
• Gene symbol: ITM2A
• Synonyms (NCBI Gene): BRICD2A, E25A
• Chromosome: X
• Chromosome location: Xq21.1
• Summary: This gene encodes a type II membrane protein that belongs to the ITM2 family. Studies in mouse suggest that it may be involved in osteo- and chondrogenic differentiation. Alternatively spliced transcript variants encoding different isoforms have been foun

miRNA Show/Hide all (52)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029091	hsa-miR-26b-5p	Microarray	19088304
MIRT645581	hsa-miR-1244	HITS-CLIP	23824327
MIRT645580	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT544145	hsa-miR-205-3p	PAR-CLIP	21572407
MIRT544144	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT544143	hsa-miR-3671	PAR-CLIP	21572407
MIRT544142	hsa-miR-607	PAR-CLIP	21572407
MIRT445743	hsa-miR-5700	PAR-CLIP	22100165
MIRT445741	hsa-miR-3942-5p	PAR-CLIP	22100165
MIRT445740	hsa-miR-4703-5p	PAR-CLIP	22100165
MIRT445739	hsa-miR-496	PAR-CLIP	22100165
MIRT445738	hsa-miR-6076	PAR-CLIP	22100165
MIRT445737	hsa-miR-6797-3p	PAR-CLIP	22100165
MIRT445736	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445735	hsa-miR-6869-5p	PAR-CLIP	22100165
MIRT445743	hsa-miR-5700	PAR-CLIP	22100165
MIRT445741	hsa-miR-3942-5p	PAR-CLIP	22100165
MIRT445740	hsa-miR-4703-5p	PAR-CLIP	22100165
MIRT445739	hsa-miR-496	PAR-CLIP	22100165
MIRT445738	hsa-miR-6076	PAR-CLIP	22100165
MIRT445737	hsa-miR-6797-3p	PAR-CLIP	22100165
MIRT445736	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445735	hsa-miR-6869-5p	PAR-CLIP	22100165
MIRT645581	hsa-miR-1244	HITS-CLIP	23824327
MIRT645580	hsa-miR-411-5p	HITS-CLIP	23824327
MIRT544145	hsa-miR-205-3p	PAR-CLIP	21572407
MIRT544144	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT544143	hsa-miR-3671	PAR-CLIP	21572407
MIRT544142	hsa-miR-607	PAR-CLIP	21572407
MIRT445743	hsa-miR-5700	PAR-CLIP	22100165
MIRT445741	hsa-miR-3942-5p	PAR-CLIP	22100165
MIRT445740	hsa-miR-4703-5p	PAR-CLIP	22100165
MIRT445739	hsa-miR-496	PAR-CLIP	22100165
MIRT445738	hsa-miR-6076	PAR-CLIP	22100165
MIRT445737	hsa-miR-6797-3p	PAR-CLIP	22100165
MIRT445736	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445735	hsa-miR-6869-5p	PAR-CLIP	22100165
MIRT445743	hsa-miR-5700	PAR-CLIP	22100165
MIRT445741	hsa-miR-3942-5p	PAR-CLIP	22100165
MIRT445740	hsa-miR-4703-5p	PAR-CLIP	22100165
MIRT445739	hsa-miR-496	PAR-CLIP	22100165
MIRT445738	hsa-miR-6076	PAR-CLIP	22100165
MIRT445737	hsa-miR-6797-3p	PAR-CLIP	22100165
MIRT445736	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT445735	hsa-miR-6869-5p	PAR-CLIP	22100165
MIRT1074513	hsa-miR-495	CLIP-seq
MIRT2452017	hsa-miR-1276	CLIP-seq
MIRT2452018	hsa-miR-4311	CLIP-seq
MIRT2452019	hsa-miR-4426	CLIP-seq
MIRT2452020	hsa-miR-4647	CLIP-seq
MIRT2452021	hsa-miR-4662b	CLIP-seq
MIRT2452022	hsa-miR-583	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IBA
GO:0002317	Process	Plasma cell differentiation	IEA
GO:0005515	Function	Protein binding	IPI	15983050, 25416956, 32296183
GO:0005794	Component	Golgi apparatus	IBA
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0042985	Process	Negative regulation of amyloid precursor protein biosynthetic process	IBA

Other IDs

• MIM: 300222
• HGNC: 6173
• e!Ensembl: ENSG00000078596

Protein

• UniProt ID: O43736
• Protein name: Integral membrane protein 2A (Protein E25)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04089	BRICHOS	135 → 226	BRICHOS domain	Domain

• Sequence:

  MVKIAFNTPTAVQKEEARQDVEALLSRTVRTQILTGKELRVATQEKEGSSGRCMLTLLGL
  SFILAGLIVGGACIYKYFMPKSTIYRGEMCFFDSEDPANSLRGGEPNFLPVTEEADIRED
  DNIAIIDVPVPSFSDSDPAAIIHDFEKGMTAYLDLLLGNCYLMPLNTSIVMPPKNLVELF
  GKLASGRYLPQTYVVREDLVAVEEIRDVSNLGIFIYQLCNNRKSFRLRRRDLLLGFNKRA
  IDKCWKIRHFPNEFIVETKICQE

• Sequence length: 263

Related Genes

No strongly related genes found yet for ITM2A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ITM2A.